AC T04076
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ID T04076
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DT 08.12.2000 (created); rio.
DT 12.03.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA TGIF
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SY 5'-TG-3' interacting factor; 5'TG3' interacting factor; HPE4; MGC39747; MGC5066; TG-interacting factor; TGFB-induced factor (TALE family homeobox); TGIF; TGIF1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002125 TGIF1; HGNC: TGIF1.
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CL C0006; homeo; 3.1.4.6.1.
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SF TALE (three amino acid loop extension) homeo domain superclass [1] [3];
SF SMAD-2 T04095 dependent interaction with Fast-2 T04100 [6];
SF competes with p300 T01427 for binding to the SMAD-2 T04095 complex [6];
SF competitive binding with Meis-2 T04115 T04116 T04117 T04118 to the same target [7];
SF half-life of phosphorylated and unphosphorylated protein is 1h and <30min respectively [8];
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EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; very low; Northern blot; mRNA (poly-A); [3].
EX brain,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX cerebellum,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX cerebral cortex,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX colon,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX frontal lobe of medial and inferior surfaces,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX frontal lobe of superolateral face,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX heart,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX kidney (right and left),,,adult; high; Northern blot; mRNA (poly-A); [3].
EX liver,,,adult; high; Northern blot; mRNA (poly-A); [3].
EX lung (right and left),,,adult; low; Northern blot; mRNA (poly-A); [3].
EX muscles,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX myelencephalon,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX occipital lobe of medial and inferior surfaces,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX occipital lobe of superolateral face,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX occipital pole,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX ovary (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [3].
EX pancreas,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX placenta,,,adult; very high; Northern blot; mRNA (poly-A); [3].
EX prostate gland,,,adult; high; Northern blot; mRNA (poly-A); [3].
EX putamen,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX small intestine,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX spinal cord,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX spleen,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX temporal lobe of medial and inferior surfaces,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX temporal lobe of superolateral face,,,adult; none; Northern blot; mRNA (poly-A); [3].
EX testis (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [3].
EX thymus,,,adult; medium; Northern blot; mRNA (poly-A); [3].
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FF acts as a repressor of RXR-alpha T01345 dependent transcriptional activation by mutual exclusive binding [3];
FF CPR (cell cycle progression restoration) gene, overexpression can overcome G1 arrest signals in the yeast cell cycle [4];
FF interacts with SMAD-2 T04095 and SMAD-3 T04096 as a transcriptional corepressor by recruitment of HDAC (histone deacetylase) into the TGFbeta-activated Smad complex instead of the coactivator p300 T01427 [6];
FF multifunctional transcriptional repressor which acts in part by interaction with HDACs (histone deacetylase) [5];
FF inhibits Meis-2 T04115 T04116 T04117 T04118 induced expression [7];
FF mutations in TGIF cause holoprosencephaly (HPE) [2];
FF links the nodal signalling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures [2];
FF EGF (epidermal growth factor) signaling causes phosphorylation of TGIF (via the Ras-Mek pathway) leading to stabilization and favoring formation of SMAD2-TGIF corepressor complexes in response to TGF beta [8];
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IN T09170 CtBP1-isoform1; human, Homo sapiens.
IN T06040 CtBP2; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T04109 hdac2-isoform1; human, Homo sapiens.
IN T04110 HDAC3; human, Homo sapiens.
IN T06377 PML; human, Homo sapiens.
IN T04095 Smad2-L; human, Homo sapiens.
IN T04096 Smad3-isoform1; human, Homo sapiens.
IN T09538 Smad3; Mammalia.
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MX M00418 V$TGIF_01.
MX M01346 V$TGIF_02.
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BS R60705.
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DR TRANSPATH: MO000013620.
DR PATHODB: MT010636.
DR PATHODB: MT010637.
DR PATHODB: MT010638.
DR PATHODB: MT010639.
DR UniProtKB: Q15583;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015443.
RX PUBMED: 10835638.
RA Gripp K. W., Wotton D., Edwards M. C., Roessler E., Ades L., Meinecke P., Richieri-Costa A., Zackai E. H., Massague J., Muenke M., Elledge S. J.
RT Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination
RL Nat. Genet. 25:205-208 (2000).
RN [3]; RE0015444.
RX PUBMED: 8537382.
RA Bertolino E., Reimund B., Wildt-Perinic D., Clerc R. G.
RT A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif
RL J. Biol. Chem. 270:31178-31188 (1995).
RN [4]; RE0015454.
RX PUBMED: 9383053.
RA Edwards M. C., Liegeois N., Horecka J., DePinho R. A., Sprague GF J. r., Tyers M., Elledge S. J.
RT Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells
RL Genetics 147:1063-1076 (1997).
RN [5]; RE0015455.
RX PUBMED: 10601270.
RA Wotton D., Lo R. S., Swaby L. A., Massague J.
RT Multiple modes of repression by the Smad transcriptional corepressor TGIF
RL J. Biol. Chem. 274:37105-37110 (1999).
RN [6]; RE0015456.
RX PUBMED: 10199400.
RA Wotton D., Lo R. S., Lee S., Massague J.
RT A Smad transcriptional corepressor
RL Cell 97:29-39 (1999).
RN [7]; RE0015476.
RX PUBMED: 10764806.
RA Yang Y., Hwang C. K., D'Souza U. M., Lee S. H., Junn E., Mouradian M. M.
RT Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription
RL J. Biol. Chem. 275:20734-20741 (2000).
RN [8]; RE0016125.
RX PUBMED: 11226163.
RA Lo R. S., Wotton D., Massague J.
RT Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF
RL EMBO J. 20:128-136 (2001).
RN [9]; RE0049335.
RX PUBMED: 15153551.
RA Dai C., Liu Y.
RT Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF.
RL J. Am. Soc. Nephrol. 15:1402-1412 (2004).
RN [10]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
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