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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T04117 XX ID T04117 XX DT 12.12.2000 (created); rio. CO Copyright (C), QIAGEN. XX FA Meis-2c XX SY myeloid ecotropic viral integration site 2c. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004024 MEIS2; HGNC: Meis2. XX CL C0006; homeo; 3.1.4.2.2.3. XX SZ 477 AA; 51.8 kDa (cDNA) (calc.), 74 kDa (SDS) [2] XX SQ MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV SQ MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN SQ EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK SQ GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH SQ ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT SQ HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS SQ PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR SQ HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ XX SC translated from EMBL #AF179897 XX FT 89 475 PF00478; IMP dehydrogenase / GMP reductase domain. FT 274 337 PS50071; HOMEOBOX_2. FT 276 341 SM00389; HOX_1. FT 277 336 PF00046; Homeobox domain. XX SF TALE (three amino acid loop extension) homeo domain superclass [1]; SF competitive binding with TGIF T04076 to the same target by sharing complementary binding sites [2]; XX CP (neuronal cell lines:) SK-N-MC, SH-SY5Y [2]. CN (cell lines:) HepG2 [2]. XX FF transcriptional activator, TGIF T04076 repressor inhibits Meis-2 induced expression [2]; XX MX M01488 V$MEIS2_01. XX BS R09633. XX DR TRANSPATH: MO000028020. DR EMBL: AF179897; DR UniProtKB: O14770-1; XX RN [1]; RE0014544. RX PUBMED: 9336443. RA Burglin T. R. RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals RL Nucleic Acids Res. 25:4173-4180 (1997). RN [2]; RE0015476. RX PUBMED: 10764806. RA Yang Y., Hwang C. K., D'Souza U. M., Lee S. H., Junn E., Mouradian M. M. RT Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription RL J. Biol. Chem. 275:20734-20741 (2000). XX //