AC T04117
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ID T04117
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DT 12.12.2000 (created); rio.
CO Copyright (C), QIAGEN.
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FA Meis-2c
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SY myeloid ecotropic viral integration site 2c.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004024 MEIS2; HGNC: Meis2.
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CL C0006; homeo; 3.1.4.2.2.3.
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SZ 477 AA; 51.8 kDa (cDNA) (calc.), 74 kDa (SDS) [2]
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SQ MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV
SQ MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN
SQ EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK
SQ GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH
SQ ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT
SQ HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS
SQ PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR
SQ HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ
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SC translated from EMBL #AF179897
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FT 89 475 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 274 337 
PS50071; HOMEOBOX_2.
FT 276 341 
SM00389; HOX_1.
FT 277 336 
PF00046; Homeobox domain.
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SF TALE (three amino acid loop extension) homeo domain superclass [1];
SF competitive binding with TGIF T04076 to the same target by sharing complementary binding sites [2];
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CP (neuronal cell lines:) SK-N-MC, SH-SY5Y [2].
CN (cell lines:) HepG2 [2].
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FF transcriptional activator, TGIF T04076 repressor inhibits Meis-2 induced expression [2];
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MX M01488 V$MEIS2_01.
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BS R09633.
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DR TRANSPATH: MO000028020.
DR EMBL: AF179897;
DR UniProtKB: O14770-1;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015476.
RX PUBMED: 10764806.
RA Yang Y., Hwang C. K., D'Souza U. M., Lee S. H., Junn E., Mouradian M. M.
RT Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription
RL J. Biol. Chem. 275:20734-20741 (2000).
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