AC T04100
AS T04120.
XX
ID T04100
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DT 11.12.2000 (created); rio.
DT 08.01.2013 (updated); ili.
CO Copyright (C), QIAGEN.
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FA FoxH1
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SY Fast-1; FAST-2; FAST1; FAST2; Fork head activin signal transducer 2; forkhead activin signal transducer 1; forkhead activin signal transducer 2; forkhead box H1; FOXH1; FoxH1-Long.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002448 Foxh1.
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CL C0023; fork head.
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SZ 401 AA; 44.0 kDa (cDNA) (calc.).
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SQ MASGWDLASTYTPTTPSPQLALAPAQGYLPCMGPRDNSQLRPPEAESLSKTPKRRKKRYL
SQ RHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNR
SQ CFHKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVL
SQ HGQPYQPPSPPPPPREGFSIKSLLGDLGKESTWPKHPGLLGQSTAAQAGTLSKGEEGMGT
SQ GPSSSSETPLWPLCSLPGPTIIEGESSQGEVIRPSPVTPDQGSWPLHLLEDSADSRGVPR
SQ RGSRASLWGQLPTSYLPIYTPNVVMPLATLPTTSCPQCPSSASPAYWSVGTESQGSQDLL
SQ CDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAPGWLLSWYSM
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SC translated from EMBL #AF110506
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FT 62 152 
SM00339; forkneu4.
FT 63 164 
fork head domain [6].
FT 64 163 
PS50039; FORK_HEAD_3.
FT 64 165 
PF00250; Fork head domain.
FT 70 78 
helix alpha 1 [6].
FT 87 97 
helix alpha 2 [6].
FT 100 104 
helix alpha 4 [6].
FT 109 119 
helix alpha 3 [6].
FT 123 125 
strand beta 1 [6].
FT 138 140 
strand beta 2 [6].
FT 149 155 helix alpha 5 [6].
XX
SF low degree of amino acid identity to FoxH1 (=Fast-1) of other species T04135 T04119 outside the DNA binding domain [3];
SF SMAD-2 T04095 dependent interaction with TGIF T04076 to a Fast-SMAD-TGIF complex [2];
SF interaction with SMAD-3 [1];
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EX mouse, Mus musculus,,,Theiler Stage 11; high; RT-PCR; total RNA; [4].
EX mouse, Mus musculus,,,Theiler Stage 13; medium; RT-PCR; total RNA; [4].
EX mouse, Mus musculus,,,Theiler Stage 15; low; RT-PCR; total RNA; [4].
EX mouse, Mus musculus,,,Theiler Stage 17; very low; RT-PCR; total RNA; [4].
EX mouse, Mus musculus,,,Theiler Stage 19; none; RT-PCR; total RNA; [4].
EX mouse, Mus musculus,,,Theiler Stage 21; none; RT-PCR; total RNA; [4].
EX mouse, Mus musculus,,,Theiler Stage 9; very high; RT-PCR; total RNA; [4].
XX
FF functions to specify the anterior primitive streak [7];
FF is essential for development of the anterior heart field [5];
FF a complex is formed in response to TGF-beta treatment which binds to ARE (Activin Response Element) and includes at least three proteins, FAST-2, SMAD-2 and SMAD-4 [1];
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IN T04095 Smad2-L; human, Homo sapiens.
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MX M03822 V$FOXH1_Q6.
MX M00809 V$FOX_Q2.
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BS R23042.
BS R73969.
BS R19513.
BS R09916.
BS R09935.
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DR TRANSPATH: MO000028003.
DR TRANSCOMPEL: C00201.
DR EMBL: AF110506;
DR EMBL: AF177770;
DR UniProtKB: O88621-1;
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RN [1]; RE0013366.
RX PUBMED: 9858566.
RA Liu B., Dou C. L., Prabhu L., Lai E.
RT FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals
RL Mol. Cell. Biol. 19:424-430 (1999).
RN [2]; RE0015456.
RX PUBMED: 10199400.
RA Wotton D., Lo R. S., Lee S., Massague J.
RT A Smad transcriptional corepressor
RL Cell 97:29-39 (1999).
RN [3]; RE0015505.
RX PUBMED: 10349617.
RA Weisberg E., Winnier G. E., Chen X., Farnsworth C. L., Hogan B. L., Whitman M.
RT A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis
RL Mech. Dev. 79:17-27 (1998).
RN [4]; RE0016391.
RX PUBMED: 9702197.
RA Labbe E., Silvestri C., Hoodless P. A., Wrana J. L., Attisano L.
RT Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.
RL Mol. Cell 2:109-120 (1998).
RN [5]; RE0034277.
RX PUBMED: 15363409.
RA von Both I., Silvestri C., Erdemir T., Lickert H., Walls J. R., Henkelman R. M., Rossant J., Harvey R. P., Attisano L., Wrana J. L.
RT Foxh1 is essential for development of the anterior heart field.
RL Dev. Cell 7:331-45 (2004).
RN [6]; RE0047915.
RX PUBMED: 11179011.
RA Saleem R. A., Banerjee-Basu S., Berry F. B., Baxevanis A. D., Walter M. A.
RT Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1.
RL Am. J. Hum. Genet. 68:627-641 (2001).
RN [7]; RE0048314.
RX PUBMED: 11358869.
RA Hoodless P. A., Pye M., Chazaud C., Labbe E., Attisano L., Rossant J., Wrana J. L.
RT FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.
RL Genes Dev. 15:1257-1271 (2001).
XX
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