AC T10027
XX
ID T10027
XX
DT 10.03.2005 (created); nvo.
DT 07.03.2016 (updated); mom.
CO Copyright (C), QIAGEN.
XX
FA MyoD
XX
SY MYF3; Myoblast determination protein 1; MyoD; MyoD1.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T10310 COUP-TF2; Mammalia.
IN T17093 E12; Mammalia.
IN T10212 E47; Mammalia.
IN T21852 HDAC1; Mammalia.
IN T15694 Id2; Mammalia.
IN T09198 Id3; mouse, Mus musculus.
IN T09402 MEF-2C; Mammalia.
IN T09547 MEF-2C; mouse, Mus musculus.
IN T09281 MLP; rat, Rattus norvegicus.
IN T11027 NFATc3; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T09284 RORalpha; mouse, Mus musculus.
IN T09538 Smad3; Mammalia.
IN T25725 SRC-1-isoform1; mouse, Mus musculus.
IN T14458 STAT3; Mammalia.
XX
MX M00804 V$E2A_Q2.
MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M00001 V$MYOD_01.
MX M00184 V$MYOD_Q6.
MX M00929 V$MYOD_Q6_01.
MX M02100 V$MYOD_Q6_02.
XX
BS R00014.
BS R20586.
BS R20589.
BS R20590.
BS R71380.
BS R71383.
BS R33222.
BS R38002.
BS R20375.
BS R22281.
BS R40114.
BS R37997.
BS R36795.
BS R72926.
BS R72927.
BS R73876.
BS R73877.
BS R73882.
BS R72928.
BS R72929.
BS R41976.
BS R28279.
BS R72930.
BS R71288.
BS R36794.
XX
DR TRANSPATH: MO000047428.
DR TRANSCOMPEL: C00027.
DR TRANSCOMPEL: C00028.
DR TRANSCOMPEL: C00029.
DR TRANSCOMPEL: C00034.
XX
RN [1]; RE0001079.
RX PUBMED: 1939278.
RA Thompson W. R., Nadal-Ginard B., Mahdavi V.
RT A MyoD1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells
RL J. Biol. Chem. 266:22678-22688 (1991).
RN [2]; RE0002467.
RX PUBMED: 1847512.
RA Wentworth B. M., Donoghue M., Engert J. C., Berglund E. B., Rosenthal N.
RT Paired MyoD-binding sites regulate myosin light chain gene expression
RL Proc. Natl. Acad. Sci. USA 88:1242-1246 (1991).
RN [3]; RE0012509.
RX PUBMED: 8759016.
RA Loveys D. A., Streiff M. B., Kato G. J.
RT E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the ld3 protein
RL Nucleic Acids Res. 24:2813-2820 (1996).
RN [4]; RE0013484.
RX PUBMED: 8918463.
RA Maira S. M., Wurtz J. M., Wasylyk B.
RT Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.
RL EMBO J. 15:5849-5865 (1996).
RN [5]; RE0020947.
RX PUBMED: 10601020.
RA Zhang J.-M., Zhao X., Wie Q., Paterson B. M.
RT Direct inhibition of G(1) cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation
RL EMBO J. 18:6983-6993 (1999).
RN [6]; RE0025127.
RX PUBMED: 10082523.
RA Biesiada E., Hamamori Y., Kedes L., Sartorelli V.
RT Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter.
RL Mol. Cell. Biol. 19:2577-2584 (1999).
RN [7]; RE0025645.
RX PUBMED: 10406466.
RA Bailey P., Downes M., Lau P., Harris J., Chen S. L., Hamamori Y., Sartorelli V., Muscat G. E.
RT The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.
RL Mol. Endocrinol. 13:1155-68 (1999).
RN [8]; RE0025726.
RX PUBMED: 12037670.
RA Simone C., Stiegler P., Bagella L., Pucci B., Bellan C., De Falco G., de Luca A., Guanti G., Puri P. L., Giordano A.
RT Activation of MyoD-dependent transcription by cdk9/cyclin T2.
RL Oncogene 21:4137-48 (2002).
RN [9]; RE0028365.
RX PUBMED: 11493654.
RA Kontaridis M. I., Liu X., Zhang L., Bennett A. M.
RT SHP-2 complex formation with the SHP-2 substrate-1 during C2C12 myogenesis.
RL J. Cell Sci. 114:2187-98 (2001).
RN [10]; RE0029592.
RX PUBMED: 12023284.
RA Zhao P., Iezzi S., Carver E., Dressman D., Gridley T., Sartorelli V., Hoffman E. P.
RT Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration.
RL J. Biol. Chem. 277:30091-101 (2002).
RN [11]; RE0030476.
RX PUBMED: 12192039.
RA Kusano S., Raab-Traub N.
RT I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.
RL Mol. Cell. Biol. 22:6393-405 (2002).
RN [12]; RE0031348.
RX PUBMED: 12665587.
RA Magenta A., Cenciarelli C., De Santa F., Fuschi P., Martelli F., Caruso M., Felsani A.
RT MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway.
RL Mol. Cell. Biol. 23:2893-906 (2003).
RN [13]; RE0031666.
RX PUBMED: 10838091.
RA Pelpel K., Leibovitch M., Fernandez A., Leibovitch S. A.
RT Mutation of MyoD-Ser237 abolishes its up-regulation by c-Mos.
RL FEBS Lett. 474:233-7 (2000).
RN [14]; RE0031711.
RX PUBMED: 11684023.
RA Puri P. L., Iezzi S., Stiegler P., Chen T. T., Schiltz R. L., Muscat G. E., Giordano A., Kedes L., Wang J. Y., Sartorelli V.
RT Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.
RL Mol. Cell 8:885-97 (2001).
RN [15]; RE0031731.
RX PUBMED: 15169898.
RA Kontaridis M. I., Eminaga S., Fornaro M., Zito C. I., Sordella R., Settleman J., Bennett A. M.
RT SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway.
RL Mol. Cell. Biol. 24:5340-52 (2004).
RN [16]; RE0032370.
RX PUBMED: 12843208.
RA Solanes G., Pedraza N., Iglesias R., Giralt M., Villarroya F.
RT Functional relationship between MyoD and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription.
RL Mol. Endocrinol. 17:1944-58 (2003).
RN [17]; RE0036266.
RX PUBMED: 8798472.
RA Ziober B. L., Kramer R. H.
RT Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoter
RL J. Biol. Chem. 271:22915-22 (1996).
RN [18]; RE0037065.
RX PUBMED: 11371506.
RA Kim Y. J., Noguchi S., Hayashi Y. K., Tsukahara T., Shimizu T., Arahata K.
RT The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression
RL Hum. Mol. Genet. 10:1129-1139 (2001).
RN [19]; RE0037159.
RX PUBMED: 9753670.
RA Tajbakhsh S., Borello U., Vivarelli E., Kelly R., Papkoff J., Duprez D., Buckingham M., Cossu G.
RT Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5
RL Development 125:4155-62 (1998).
RN [20]; RE0039372.
RX PUBMED: 10985858.
RA Fraidenraich D., Iwahori A., Rudnicki M., Basilico C.
RT Activation of fgf4 gene expression in the myotomes is regulated by myogenic bHLH factors and by sonic hedgehog
RL Dev. Biol. 225:392-406 (2000).
RN [21]; RE0039511.
RX PUBMED: 9235903.
RA Anand G., Yin X., Shahidi A. K., Grove L., Prochownik E. V.
RT Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome
RL J. Biol. Chem. 272:19140-51 (1997).
RN [22]; RE0040401.
RX PUBMED: 12050162.
RA Sakamoto K., Yamaguchi S., Ando R., Miyawaki A., Kabasawa Y., Takagi M., Li C. L., Perbal B., Katsube K.
RT The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway
RL J. Biol. Chem. 277:29399-405 (2002).
RN [23]; RE0040496.
RX PUBMED: 9525963.
RA Ichida M., Endo H., Ikeda U., Matsuda C., Ueno E., Shimada K., Kagawa Y.
RT MyoD is indispensable for muscle-specific alternative splicing in mouse mitochondrial ATP synthase gamma-subunit pre-mRNA
RL J. Biol. Chem. 273:8492-501 (1998).
RN [24]; RE0041087.
RX PUBMED: 12427866.
RA Amack J. D., Reagan S. R., Mahadevan M. S.
RT Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD
RL J. Cell Biol. 159:419-29 (2002).
RN [25]; RE0041507.
RX PUBMED: 12947115.
RA Kataoka Y., Matsumura I., Ezoe S., Nakata S., Takigawa E., Sato Y., Kawasaki A., Yokota T., Nakajima K., Felsani A., Kanakura Y.
RT Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts
RL J. Biol. Chem. 278:44178-87 (2003).
RN [26]; RE0042273.
RX PUBMED: 14623929.
RA Kirk S. P., Oldham J. M., Jeanplong F., Bass J. J.
RT Insulin-like growth factor-II delays early but enhances late regeneration of skeletal muscle
RL J. Histochem. Cytochem. 51:1611-20 (2003).
RN [27]; RE0042296.
RX PUBMED: 10619020.
RA Sartorelli V., Puri P. L., Hamamori Y., Ogryzko V., Chung G., Nakatani Y., Wang J. Y., Kedes L.
RT Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
RL Mol. Cell 4:725-34 (1999).
RN [28]; RE0042297.
RX PUBMED: 10944526.
RA Polesskaya A., Duquet A., Naguibneva I., Weise C., Vervisch A., Bengal E., Hucho F., Robin P., Harel-Bellan A.
RT CREB-binding Protein/p300 activates MyoD by acetylation
RL J. Biol. Chem. 275:34359-64 (2000).
RN [29]; RE0042298.
RX PUBMED: 9659901.
RA Puri P. L., Sartorelli V., Yang X. J., Hamamori Y., Ogryzko V. V., Howard B. H., Kedes L., Wang J. Y., Graessmann A., Nakatani Y., Levrero M.
RT Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
RL Mol. Cell 1:35-45 (1997).
RN [30]; RE0042299.
RX PUBMED: 12244043.
RA Langley B., Thomas M., Bishop A., Sharma M., Gilmour S., Kambadur R.
RT Myostatin inhibits myoblast differentiation by down-regulating MyoD expression
RL J. Biol. Chem. 277:49831-40 (2002).
RN [31]; RE0042300.
RX PUBMED: 12242286.
RA Spiller M. P., Kambadur R., Jeanplong F., Thomas M., Martyn J. K., Bass J. J., Sharma M.
RT The myostatin gene is a downstream target gene of basic helix-loop-helix transcription factor MyoD
RL Mol. Cell. Biol. 22:7066-82 (2002).
RN [32]; RE0042302.
RX PUBMED: 11711431.
RA Liu D., Black B. L., Derynck R.
RT TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
RL Genes Dev. 15:2950-66 (2001).
RN [33]; RE0042310.
RX PUBMED: 8631961.
RA Skerjanc I. S., Truong J., Filion P., McBurney M. W.
RT A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity
RL J. Biol. Chem. 271:3555-61 (1996).
RN [34]; RE0042312.
RX PUBMED: 7794894.
RA Baudier J., Bergeret E., Bertacchi N., Weintraub H., Gagnon J., Garin J.
RT Interactions of myogenic bHLH transcription factors with calcium-binding calmodulin and S100a (alpha alpha) proteins
RL Biochemistry 34:7834-46 (1995).
RN [35]; RE0042319.
RX PUBMED: 9482738.
RA Lemercier C., To R. Q., Carrasco R. A., Konieczny S. F.
RT The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD
RL EMBO J. 17:1412-22 (1998).
RN [36]; RE0042354.
RX PUBMED: 9234731.
RA Kong Y., Flick M. J., Kudla A. J., Konieczny S. F.
RT Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD
RL Mol. Cell. Biol. 17:4750-60 (1997).
RN [37]; RE0042357.
RX PUBMED: 1371288.
RA Boukamp P., Chen J., Gonzales F., Jones P. A., Fusenig N. E.
RT Progressive stages of "transdifferentiation" from epidermal to mesenchymal phenotype induced by MyoD1 transfection, 5-aza-2'-deoxycytidine treatment, and selection for reduced cell attachment in the human keratinocyte line HaCaT
RL J. Cell Biol. 116:1257-71 (1992).
RN [38]; RE0042360.
RX PUBMED: 11551968.
RA Allen D. L., Sartorius C. A., Sycuro L. K., Leinwand L. A.
RT Different pathways regulate expression of the skeletal myosin heavy chain genes
RL J. Biol. Chem. 276:43524-33 (2001).
RN [39]; RE0043816.
RX PUBMED: 10625651.
RA Sugiyama Y., Suzuki A., Kishikawa M., Akutsu R., Hirose T., Waye M. M., Tsui S. K., Yoshida S., Ohno S.
RT Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
RL J. Biol. Chem. 275:1095-104 (2000).
RN [40]; RE0046109.
RX PUBMED: 15282335.
RA Rochat A., Fernandez A., Vandromme M., Moles J. P., Bouschet T., Carnac G., Lamb N. J.
RT Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy
RL Mol. Biol. Cell 15:4544-55 (2004).
RN [41]; RE0046631.
RX PUBMED: 15501225.
RA Olguin H. C., Olwin B. B.
RT Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal
RL Dev. Biol. 275:375-88 (2004).
RN [42]; RE0047136.
RX PUBMED: 15964791.
RA Kim C. H., Xiong W. C., Mei L.
RT Inhibition of MuSK expression by CREB interacting with a CRE-like element and MyoD
RL Mol. Cell. Biol. 25:5329-38 (2005).
RN [43]; RE0048030.
RX PUBMED: 15563453.
RA Wu H. Y., Hamamori Y., Xu J., Chang S. C., Saluna T., Chang M. F., O'Malley B. W., Kedes L.
RT Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.
RL J. Biol. Chem. 280:3129-3137 (2005).
RN [44]; RE0048056.
RX PUBMED: 15531760.
RA Tintignac L. A., Lagirand J., Batonnet S., Sirri V., Leibovitch M. P., Leibovitch S. A.
RT Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase.
RL J. Biol. Chem. 280:2847-2856 (2005).
RN [45]; RE0048066.
RX PUBMED: 12887892.
RA Fulco M., Schiltz R. L., Iezzi S., King M. T., Zhao P., Kashiwaya Y., Hoffman E., Veech R. L., Sartorelli V.
RT Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.
RL Mol. Cell 12:51-62 (2003).
RN [46]; RE0048095.
RX PUBMED: 15743821.
RA Micheli L., Leonardi L., Conti F., Buanne P., Canu N., Caruso M., Tirone F.
RT PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.
RL Mol. Cell. Biol. 25:2242-2259 (2005).
RN [47]; RE0048109.
RX PUBMED: 10817756.
RA Chen S. L., Dowhan D. H., Hosking B. M., Muscat G. E.
RT The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation.
RL Genes Dev. 14:1209-1228 (2000).
RN [48]; RE0048173.
RX PUBMED: 9862959.
RA Lau P., Bailey P., Dowhan D. H., Muscat G. E.
RT Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.
RL Nucleic Acids Res. 27:411-420 (1999).
RN [49]; RE0048230.
RX PUBMED: 16007160.
RA Bloor A. J., Kotsopoulou E., Hayward P., Champion B. R., Green A. R.
RT RFP represses transcriptional activation by bHLH transcription factors.
RL Oncogene 24:6729-6736 (2005).
RN [50]; RE0048956.
RX PUBMED: 10924525.
RA Firulli B. A., Hadzic D. B., McDaid J. R., Firulli A. B.
RT The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.
RL J. Biol. Chem. 275:33567-33573 (2000).
RN [51]; RE0049248.
RX PUBMED: 17202138.
RA Wrighton K. H., Liang M., Bryan B., Luo K., Liu M., Feng X. H., Lin X.
RT Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation.
RL J. Biol. Chem. 282:6517-6524 (2007).
RN [52]; RE0051704.
RX PUBMED: 9826778.
RA Bailey P., Sartorelli V., Hamamori Y., Muscat G. E.
RT The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD.
RL Nucleic Acids Res. 26:5501-5510 (1998).
RN [53]; RE0052561.
RX PUBMED: 11285237.
RA Mal A., Sturniolo M., Schiltz R. L., Ghosh M. K., Harter M. L.
RT A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program.
RL EMBO J. 20:1739-1753 (2001).
RN [54]; RE0065536.
RX PUBMED: 18676376.
RA Armand A. S., Bourajjaj M., Martinez-Martinez S., el Azzouzi H., da Costa Martins P. A., Hatzis P., Seidler T., Redondo J. M., De Windt L. J.
RT Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis.
RL J. Biol. Chem. 283:29004-29010 (2008).
XX
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