AC T00433
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ID T00433
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DT 20.10.1992 (created); ewi.
DT 23.04.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA ITF-2
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SY bHLHb19; E2-2; E32; ITF-2; ITF2; MGC149723; MGC149724; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4; Tcf4; transcription factor 4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004663 TCF4; HGNC: Tcf4.
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CL C0010; bHLH; 1.2.1.0.2.
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SF positions refer to the presumably complete sequence of SEF2-1B in [8];
SF appears to occur in several splice variants [8];
SF a novel loop-helix motif has been proposed in the trans-activation domain which is also found in E2A proteins, HEB, and Daughterless [7];
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FF activator [7] [2];
FF in pre-B cells expressed together with E2A proteins, but switched off in mature B cells [6];
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IN T02872 beta-catenin; human, Homo sapiens.
IN T14513 beta-catenin; Mammalia.
IN T00241 Egr-1; human, Homo sapiens.
IN T14243 GKLF; human, Homo sapiens.
IN T01503 HTF4; human, Homo sapiens.
IN T01606 Id1.25; rat, Rattus norvegicus.
IN T00403 Id1; mouse, Mus musculus.
IN T01807 Id1; rat, Rattus norvegicus.
IN T14419 Id1; human, Homo sapiens.
IN T01212 Id2; human, Homo sapiens.
IN T09205 Id3; human, Homo sapiens.
IN T00432 ITF-1; human, Homo sapiens.
IN T04902 msc; human, Homo sapiens.
IN T00521 Myf-5; human, Homo sapiens.
IN T00949 Myf-5; clawed frog, Xenopus laevis.
IN T00522 Myf-6; human, Homo sapiens.
IN T00524 MyoD; clawed frog, Xenopus laevis.
IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T00527 MyoD; monkey, Cercopithecus aethiops.
IN T01128 MyoD; chick, Gallus gallus.
IN T00520 Myogenin; human, Homo sapiens.
IN T01448 Tal1-PP22; human, Homo sapiens.
IN T00790 Tal1-PP42; human, Homo sapiens.
IN T09977 TWIST; human, Homo sapiens.
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MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M00070 V$TAL1BETAITF2_01.
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BS R28343.
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DR TRANSPATH: MO000024921.
DR UniProtKB: P15884;
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RN [1]; RE0000238.
RX PUBMED: 1649701.
RA Lassar A. B., Davis R. L., Wright W. E., Kadesch T., Murre C., Voronova A., Baltimore D., Weintraub H.
RT Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo
RL Cell 66:305-315 (1991).
RN [2]; RE0002660.
RX PUBMED: 2105528.
RA Henthorn P., Kiledjian M., Kadesch T.
RT Two distinct transcription factors that bind the immunoglobulin enhancer muE5/kappaE2 motif
RL Science 247:467-470 (1990).
RN [3]; RE0002932.
RX PUBMED: 8289805.
RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. E., Hu J.-S., Kingston R. E., Baer R.
RT Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins
RL Mol. Cell. Biol. 14:1256-1265 (1994).
RN [4]; RE0003087.
RX PUBMED: 1312219.
RA Hu J.-S., Olson E. N., Kingston R. E.
RT HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
RL Mol. Cell. Biol. 12:1031-1042 (1992).
RN [5]; RE0003541.
RX PUBMED: 7623812.
RA Einarson M. B., Chao M. V.
RT Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells
RL Mol. Cell. Biol. 15:4175-4183 (1995).
RN [6]; RE0003542.
RX PUBMED: 8497267.
RA Bain G., Gruenwald S., Murre C.
RT E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins
RL Mol. Cell. Biol. 13:3522-3529 (1993).
RN [7]; RE0003543.
RX PUBMED: 8423802.
RA Quong M. W., Massari M. E., Zwart R., Murre C.
RT A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
RL Mol. Cell. Biol. 13:792-800 (1993).
RN [8]; RE0003741.
RX PUBMED: 1681116.
RA Corneliussen B., Thornell A., Hallberg B., Grundstroem T.
RT Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers
RL J. Virol. 65:6084-6093 (1991).
RN [9]; RE0017215.
RX PUBMED: 9584154.
RA Massari M. E., Rivera R. R., Voland J. R., Quong M. W., Breit T. M., van Dongen J. J., de Smit O., Murre C.
RT Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes
RL Mol. Cell. Biol. 18:3130-3139 (1998).
RN [10]; RE0047866.
RX PUBMED: 16135793.
RA Kawai-Kowase K., Kumar M. S., Hoofnagle M. H., Yoshida T., Owens G. K.
RT PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins.
RL Mol. Cell. Biol. 25:8009-8023 (2005).
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