TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00403 XX ID T00403 XX DT 22.10.1992 (created); ewi. DT 23.07.2013 (updated); yre. CO Copyright (C), QIAGEN. XX FA Id1 XX SY Id; Id1; inhibitor of DNA-binding 1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006257 Id1. XX CL C0011; HLH; XX SF no basic (=DNA-binding) domain; SF homodimerization (KD = 5.3 uM) and homotetramerization (KD = 0.36 uM) [7]; SF avidly binding to MyoD (KD = 0.7 uM, KD = 0.01 uM) [7]; SF the loop region is mainly responsible for dimerization specificity [9]; XX CP undifferentiated cells. XX FF inhibitor of bHLH proteins (e.g. E47, MyoD, not: TFE3), inhibits myeloid and erythroid differentiation [6] [14] [15]; FF down-regulated at confluence or differentiation [5] [6] [2]; FF 10-fold lower levels in myotubes than in myoblasts [6]; FF inhibits B cell development [13]; FF but also enhanced transiently upon osteogenic differentiation induced by BMP-2 [10]; FF enhanced by glucocorticoids in MC3T3E1 [1]; FF antagonizes growth suppression by E12/E47, involved in growth induction by serum growth factors [11]; FF involved in muscle atrophy upon disuse [12]; FF inhibits trophoblast differentiation of choriocarcinoma cells while Hand1 T01569 induces trophoblast formation in preimplantation embryos [16]; XX IN T00204 E12; human, Homo sapiens. IN T00675 E12; rat, Rattus norvegicus. IN T01787 E12; clawed frog, Xenopus laevis. IN T00207 E47; human, Homo sapiens. IN T00674 E47; rat, Rattus norvegicus. IN T01788 E47; mouse, Mus musculus. IN T09513 HTF4; mouse, Mus musculus. IN T00403 Id1; mouse, Mus musculus. IN T00404 Id2; mouse, Mus musculus. IN T01212 Id2; human, Homo sapiens. IN T00432 ITF-1; human, Homo sapiens. IN T00433 ITF-2; human, Homo sapiens. IN T19028 ITF-2; mouse, Mus musculus. IN T01659 m3; mouse, Mus musculus. IN T13873 MITF; Mammalia. IN T09283 MRF4; rat, Rattus norvegicus. IN T00521 Myf-5; human, Homo sapiens. IN T10006 Myf-5; human, Homo sapiens. IN T00524 MyoD; clawed frog, Xenopus laevis. IN T00525 MyoD; human, Homo sapiens. IN T00526 MyoD; mouse, Mus musculus. IN T00527 MyoD; monkey, Cercopithecus aethiops. IN T01128 MyoD; chick, Gallus gallus. IN T09177 MyoD; mouse, Mus musculus. IN T00528 myogenin; mouse, Mus musculus. XX DR TRANSPATH: MO000024899. DR UniProtKB: P20067; XX RN [1]; RE0000008. RX PUBMED: 1719977. RA Ogata T., Noda M. RT Expression of Id, a negative regulator of helix-loop-helix DNA binding proteins, is down-regulated at confluence and enhanced by dexamethasone in a mouse osteoblastic cell line, MC3T3E1 RL Biochem. Biophys. Res. Commun. 180:1194-1199 (1991). RN [2]; RE0000055. RX PUBMED: 2156629. RA Benezra R., Davis R. L., Lockshon D., Turner D. L., Weintraub H. RT The protein Id: a negative regulator of helix-loop-helix DNA binding proteins RL Cell 61:49-59 (1990). RN [3]; RE0001511. RX PUBMED: 1922066. RA Sun X.-H., Copeland N. G., Jenkins N. A., Baltimore D. RT Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins RL Mol. Cell. Biol. 11:5603-5611 (1991). RN [4]; RE0001588. RX PUBMED: 1899281. RA Pongubala J. M. R., Atchison M. L. RT Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors RL Mol. Cell. Biol. 11:1040-1047 (1991). RN [5]; RE0002863. RX PUBMED: 1944284. RA Wilson R. B., Kiledjian M., Shen C.-P., Benezra R., Zwollo P., Dymecki S. M., Desiderio S. V., Kadesch T. RT Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development RL Mol. Cell. Biol. 11:6185-6191 (1991). RN [6]; RE0003109. RX PUBMED: 1644289. RA Jen Y., Weintraub H., Benezra R. RT Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins RL Genes Dev. 6:1466-1479 (1992). RN [7]; RE0003415. RX PUBMED: 8248126. RA Fairman R., Beran-Steed R. K., Anthony-Cahill S. J., Lear J. D., Stafford III W. F., DeGrado W. F., Benfield P. A., Brenner S. L. RT Multiple oligomeric states regulate the DNA binding of helix-loop-helix proteins RL Proc. Natl. Acad. Sci. USA 90:10429-10433 (1993). RN [8]; RE0004163. RX PUBMED: 1280901. RA Murray S. S., Glackin C. A., Winters K. A., Gazit D., Kahn A. J., Murray E. J. RT Expression of helix-loop-helix regulatory genes during differentiation of mouse osteoblastic cells RL J. Bone Miner. Res. 7:1131-1138 (1992). RN [9]; RE0004164. RX PUBMED: 8247002. RA Pesce S., Benezra R. RT The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity RL Mol. Cell. Biol. 13:7874-7880 (1993). RN [10]; RE0004165. RX PUBMED: 8415680. RA Ogata T., Wozney J. M., Benezra R., Noda M. RT Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells RL Proc. Natl. Acad. Sci. USA 90:9219-9222 (1993). RN [11]; RE0004168. RX PUBMED: 8197168. RA Barone M. V., Pepperkok R., Peverali F. A., Philipson L. RT Id proteins control growth induction in mammalian cells RL Proc. Natl. Acad. Sci. USA 91:4985-4988 (1994). RN [12]; RE0004169. RX PUBMED: 8170962. RA Gundersen K., Merlie J. P. RT Id-1 as a possible transcriptional mediator of muscle disuse atrophy RL Proc. Natl. Acad. Sci. USA 91:3647-3651 (1994). RN [13]; RE0004170. RX PUBMED: 8001126. RA Sun X.-H. RT Constitutive expression of the Id1 gene impairs mouse B cell development RL Cell 79:893-900 (1994). RN [14]; RE0005536. RX PUBMED: 7629100. RA Lister J., Forrester W. C., Baron M. H. RT Inhibition of an erythroid differentiation switch by the helix-loop-helix protein Id1 RL J. Biol. Chem. 270:17939-17946 (1995). RN [15]; RE0005838. RX PUBMED: 8106486. RA Shoji W., Yamamoto T., Obinata M. RT The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells RL J. Biol. Chem. 269:5078-5084 (1994). RN [16]; RE0015952. RX PUBMED: 7671815. RA Cross J. C., Flannery M. L., Blanar M. A., Steingrimsson E., Jenkins N. A., Copeland N. G., Rutter W. J., Werb Z. RT Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development RL Development 121:2513-2523 (1995). RN [17]; RE0039511. RX PUBMED: 9235903. RA Anand G., Yin X., Shahidi A. K., Grove L., Prochownik E. V. RT Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome RL J. Biol. Chem. 272:19140-51 (1997). RN [18]; RE0048980. RX PUBMED: 9242638. RA Langlands K., Yin X., Anand G., Prochownik E. V. RT Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. RL J. Biol. Chem. 272:19785-19793 (1997). RN [19]; RE0049142. RX PUBMED: 15280210. RA Samanta J., Kessler J. A. RT Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. RL Development 131:4131-4142 (2004). RN [20]; RE0052824. RX PUBMED: 17068200. RA Li J. M., Mogi M., Tsukuda K., Tomochika H., Iwanami J., Min L. J., Nahmias C., Iwai M., Horiuchi M. RT Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. RL Mol. Endocrinol. 21:499-511 (2007). RN [21]; RE0066056. RX PUBMED: 18652815. RA Kirjavainen A., Sulg M., Heyd F., Alitalo K., Yla-Herttuala S., Moroy T., Petrova T. V., Pirvola U. RT Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. RL Dev. Biol. 322:33-45 (2008). RN [22]; RE0069850. RX PUBMED: 17012234. RA Yang Y., Liou H. C., Sun X. H. RT Id1 potentiates NF-kappaB activation upon T cell receptor signaling. RL J. Biol. Chem. 281:34989-34996 (2006). XX //