AC T00403
XX
ID T00403
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DT 22.10.1992 (created); ewi.
DT 23.07.2013 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA Id1
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SY Id; Id1; inhibitor of DNA-binding 1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006257 Id1.
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CL C0011; HLH; 1.2.8.0.1.
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SF no basic (=DNA-binding) domain;
SF homodimerization (KD = 5.3 uM) and homotetramerization (KD = 0.36 uM) [7];
SF avidly binding to MyoD (KD = 0.7 uM, KD = 0.01 uM) [7];
SF the loop region is mainly responsible for dimerization specificity [9];
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CP undifferentiated cells.
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FF inhibitor of bHLH proteins (e.g. E47, MyoD, not: TFE3), inhibits myeloid and erythroid differentiation [6] [14] [15];
FF down-regulated at confluence or differentiation [5] [6] [2];
FF 10-fold lower levels in myotubes than in myoblasts [6];
FF inhibits B cell development [13];
FF but also enhanced transiently upon osteogenic differentiation induced by BMP-2 [10];
FF enhanced by glucocorticoids in MC3T3E1 [1];
FF antagonizes growth suppression by E12/E47, involved in growth induction by serum growth factors [11];
FF involved in muscle atrophy upon disuse [12];
FF inhibits trophoblast differentiation of choriocarcinoma cells while Hand1 T01569 induces trophoblast formation in preimplantation embryos [16];
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IN T00204 E12; human, Homo sapiens.
IN T00675 E12; rat, Rattus norvegicus.
IN T01787 E12; clawed frog, Xenopus laevis.
IN T00207 E47; human, Homo sapiens.
IN T00674 E47; rat, Rattus norvegicus.
IN T01788 E47; mouse, Mus musculus.
IN T09513 HTF4; mouse, Mus musculus.
IN T00403 Id1; mouse, Mus musculus.
IN T00404 Id2; mouse, Mus musculus.
IN T01212 Id2; human, Homo sapiens.
IN T00432 ITF-1; human, Homo sapiens.
IN T00433 ITF-2; human, Homo sapiens.
IN T19028 ITF-2; mouse, Mus musculus.
IN T01659 m3; mouse, Mus musculus.
IN T13873 MITF; Mammalia.
IN T09283 MRF4; rat, Rattus norvegicus.
IN T00521 Myf-5; human, Homo sapiens.
IN T10006 Myf-5; human, Homo sapiens.
IN T00524 MyoD; clawed frog, Xenopus laevis.
IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T00527 MyoD; monkey, Cercopithecus aethiops.
IN T01128 MyoD; chick, Gallus gallus.
IN T09177 MyoD; mouse, Mus musculus.
IN T00528 myogenin; mouse, Mus musculus.
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DR TRANSPATH: MO000024899.
DR UniProtKB: P20067;
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RN [1]; RE0000008.
RX PUBMED: 1719977.
RA Ogata T., Noda M.
RT Expression of Id, a negative regulator of helix-loop-helix DNA binding proteins, is down-regulated at confluence and enhanced by dexamethasone in a mouse osteoblastic cell line, MC3T3E1
RL Biochem. Biophys. Res. Commun. 180:1194-1199 (1991).
RN [2]; RE0000055.
RX PUBMED: 2156629.
RA Benezra R., Davis R. L., Lockshon D., Turner D. L., Weintraub H.
RT The protein Id: a negative regulator of helix-loop-helix DNA binding proteins
RL Cell 61:49-59 (1990).
RN [3]; RE0001511.
RX PUBMED: 1922066.
RA Sun X.-H., Copeland N. G., Jenkins N. A., Baltimore D.
RT Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
RL Mol. Cell. Biol. 11:5603-5611 (1991).
RN [4]; RE0001588.
RX PUBMED: 1899281.
RA Pongubala J. M. R., Atchison M. L.
RT Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors
RL Mol. Cell. Biol. 11:1040-1047 (1991).
RN [5]; RE0002863.
RX PUBMED: 1944284.
RA Wilson R. B., Kiledjian M., Shen C.-P., Benezra R., Zwollo P., Dymecki S. M., Desiderio S. V., Kadesch T.
RT Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development
RL Mol. Cell. Biol. 11:6185-6191 (1991).
RN [6]; RE0003109.
RX PUBMED: 1644289.
RA Jen Y., Weintraub H., Benezra R.
RT Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins
RL Genes Dev. 6:1466-1479 (1992).
RN [7]; RE0003415.
RX PUBMED: 8248126.
RA Fairman R., Beran-Steed R. K., Anthony-Cahill S. J., Lear J. D., Stafford III W. F., DeGrado W. F., Benfield P. A., Brenner S. L.
RT Multiple oligomeric states regulate the DNA binding of helix-loop-helix proteins
RL Proc. Natl. Acad. Sci. USA 90:10429-10433 (1993).
RN [8]; RE0004163.
RX PUBMED: 1280901.
RA Murray S. S., Glackin C. A., Winters K. A., Gazit D., Kahn A. J., Murray E. J.
RT Expression of helix-loop-helix regulatory genes during differentiation of mouse osteoblastic cells
RL J. Bone Miner. Res. 7:1131-1138 (1992).
RN [9]; RE0004164.
RX PUBMED: 8247002.
RA Pesce S., Benezra R.
RT The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity
RL Mol. Cell. Biol. 13:7874-7880 (1993).
RN [10]; RE0004165.
RX PUBMED: 8415680.
RA Ogata T., Wozney J. M., Benezra R., Noda M.
RT Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells
RL Proc. Natl. Acad. Sci. USA 90:9219-9222 (1993).
RN [11]; RE0004168.
RX PUBMED: 8197168.
RA Barone M. V., Pepperkok R., Peverali F. A., Philipson L.
RT Id proteins control growth induction in mammalian cells
RL Proc. Natl. Acad. Sci. USA 91:4985-4988 (1994).
RN [12]; RE0004169.
RX PUBMED: 8170962.
RA Gundersen K., Merlie J. P.
RT Id-1 as a possible transcriptional mediator of muscle disuse atrophy
RL Proc. Natl. Acad. Sci. USA 91:3647-3651 (1994).
RN [13]; RE0004170.
RX PUBMED: 8001126.
RA Sun X.-H.
RT Constitutive expression of the Id1 gene impairs mouse B cell development
RL Cell 79:893-900 (1994).
RN [14]; RE0005536.
RX PUBMED: 7629100.
RA Lister J., Forrester W. C., Baron M. H.
RT Inhibition of an erythroid differentiation switch by the helix-loop-helix protein Id1
RL J. Biol. Chem. 270:17939-17946 (1995).
RN [15]; RE0005838.
RX PUBMED: 8106486.
RA Shoji W., Yamamoto T., Obinata M.
RT The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells
RL J. Biol. Chem. 269:5078-5084 (1994).
RN [16]; RE0015952.
RX PUBMED: 7671815.
RA Cross J. C., Flannery M. L., Blanar M. A., Steingrimsson E., Jenkins N. A., Copeland N. G., Rutter W. J., Werb Z.
RT Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development
RL Development 121:2513-2523 (1995).
RN [17]; RE0039511.
RX PUBMED: 9235903.
RA Anand G., Yin X., Shahidi A. K., Grove L., Prochownik E. V.
RT Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome
RL J. Biol. Chem. 272:19140-51 (1997).
RN [18]; RE0048980.
RX PUBMED: 9242638.
RA Langlands K., Yin X., Anand G., Prochownik E. V.
RT Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.
RL J. Biol. Chem. 272:19785-19793 (1997).
RN [19]; RE0049142.
RX PUBMED: 15280210.
RA Samanta J., Kessler J. A.
RT Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation.
RL Development 131:4131-4142 (2004).
RN [20]; RE0052824.
RX PUBMED: 17068200.
RA Li J. M., Mogi M., Tsukuda K., Tomochika H., Iwanami J., Min L. J., Nahmias C., Iwai M., Horiuchi M.
RT Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1.
RL Mol. Endocrinol. 21:499-511 (2007).
RN [21]; RE0066056.
RX PUBMED: 18652815.
RA Kirjavainen A., Sulg M., Heyd F., Alitalo K., Yla-Herttuala S., Moroy T., Petrova T. V., Pirvola U.
RT Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.
RL Dev. Biol. 322:33-45 (2008).
RN [22]; RE0069850.
RX PUBMED: 17012234.
RA Yang Y., Liou H. C., Sun X. H.
RT Id1 potentiates NF-kappaB activation upon T cell receptor signaling.
RL J. Biol. Chem. 281:34989-34996 (2006).
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