AC T09283
XX
ID T09283
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DT 30.08.2006 (created); man.
DT 11.12.2006 (updated); kau.
CO Copyright (C), QIAGEN.
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FA MRF4
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SY MRF4; Myf-6.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001055 Myf6.
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CL C0010; bHLH.
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SZ 242 AA; 27.0 kDa (cDNA) (calc.).
XX
SQ MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEE
SQ HVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRT
SQ VANPNQRLPKVEILRSAINYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFL
SQ RTCSPQWPSVSDHSRGLVITAKEGGASVDASASSSLQRLSSIVDSISSEERKLPSVEEVV
SQ EK
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SC Swiss-Prot#P19335
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FT 3 93 
PF01586; Myogenic Basic domain.
FT 3 98 
SM00520; BASIC.
FT 93 145 
PS50888; HLH.
FT 94 145 
PF00010; Helix-loop-helix DNA-binding domain.
FT 99 99 
threonine-phosphorylation by PKC inhibits DNA-binding [9].
FT 99 150 
SM00353; finulus.
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IN T00403 Id1; mouse, Mus musculus.
IN T10004 Id2; mouse, Mus musculus.
IN T09198 Id3; mouse, Mus musculus.
IN T09281 MLP; rat, Rattus norvegicus.
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MX M00804 V$E2A_Q2.
MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M03831 V$MRF4_Q3.
MX M00929 V$MYOD_Q6_01.
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BS R00242.
BS R02898.
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DR TRANSPATH: MO000086016.
DR EMBL: M27151;
DR EMBL: M84685;
DR UniProtKB: P19335;
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RN [1]; RE0000703.
RX PUBMED: 2560751.
RA Rhodes S. J., Konieczny S. F.
RT Identification of MRF4: a new member of the muscle regulatory factor gene family
RL Genes Dev. 3:2050-2061 (1989).
RN [2]; RE0000968.
RX PUBMED: 1847137.
RA Chakraborty T., Brennan T., Olson E.
RT Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding
RL J. Biol. Chem. 266:2878-2882 (1991).
RN [3]; RE0001506.
RX PUBMED: 1658626.
RA Chakraborty T., Olson E. N.
RT Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF4
RL Mol. Cell. Biol. 11:6103-6108 (1991).
RN [4]; RE0001507.
RX PUBMED: 1695319.
RA Yutzey K. E., Rhodes S. J., Konieczny S. F.
RT Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4
RL Mol. Cell. Biol. 10:3934-3944 (1990).
RN [5]; RE0002987.
RX PUBMED: 1328851.
RA Mak K.-L., To R. Q., Kong Y., Konieczny S. F.
RT The MRF4 activation domain is required to induce muscle-specific gene expression
RL Mol. Cell. Biol. 12:4334-4346 (1992).
RN [6]; RE0003271.
RX PUBMED: 1715299.
RA Hinterberger T. J., Sassoon D. A., Rhodes S. J., Konieczny S. F.
RT Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development
RL Dev. Biol. 147:144-156 (1991).
RN [7]; RE0003274.
RX PUBMED: 1639267.
RA Hinterberger T. J., Mays J. L., Konieczny S. F.
RT Structure and myofiber-specific expression of the rat muscle regulatory gene MRF4
RL Gene 117:201-207 (1992).
RN [8]; RE0003406.
RX PUBMED: 1311321.
RA Lin H., Konieczny S. F.
RT Identification of MRF4, myogenin, and E12 oligomer complexes by cheical cross-linking and two-dimensional gel electrophoresis
RL J. Biol. Chem. 267:4773-4780 (1992).
RN [9]; RE0003407.
RX PUBMED: 8413199.
RA Hardy S., Kong Y., Konieczny S. F.
RT Fibroblast growth factor inhibits MRF4 activity independently of the phosporylation status of a conserved threonine residue within the DNA-binding domain
RL Mol. Cell. Biol. 13:5943-5956 (1993).
RN [10]; RE0042354.
RX PUBMED: 9234731.
RA Kong Y., Flick M. J., Kudla A. J., Konieczny S. F.
RT Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD
RL Mol. Cell. Biol. 17:4750-60 (1997).
RN [11]; RE0048980.
RX PUBMED: 9242638.
RA Langlands K., Yin X., Anand G., Prochownik E. V.
RT Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.
RL J. Biol. Chem. 272:19785-19793 (1997).
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