AC T00432
XX
ID T00432
XX
DT 20.10.1992 (created); ewi.
DT 08.03.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA ITF-1
XX
SY E2-5; ITF-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003922 TCF3; HGNC: TCF3.
XX
CL C0010; bHLH.
XX
SZ 582 AA; 59.9 kDa (cDNA) (calc.).
XX
SQ GGGECLAWCGPSAVHRCADVGLGMVSARTAPGKSGERGAYASFGRDAGVGGLTQAGFLSG
SQ ELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPS
SQ SGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLP
SQ LPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHT
SQ PPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQ
SQ WPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASG
SQ FTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRA
SQ GATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSTDEVLSLEEKDLRDRERRM
SQ ANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLN
SQ PKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM
XX
SC Swiss-Prot#P15883 (partial sequence)
XX
FT 36 514 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 475 531 
PS50888; HLH.
FT 478 531 
PF00010; Helix-loop-helix DNA-binding domain.
FT 483 536 
SM00353; finulus.
XX
SF splice variant of E12, identical to E47 except its first exon [2];
XX
FF activator;
FF cooperating with TFE3, it can mediate lymphoid-specific activation through IgH enhancer elements muE5 and muE3;
FF in this context, ITF-1 displaces a repressor (ZEB) thus giving way for activation by TFE3 [1];
XX
IN T00403 Id1; mouse, Mus musculus.
IN T00433 ITF-2; human, Homo sapiens.
IN T10018 Lyl-1; human, Homo sapiens.
IN T00521 Myf-5; human, Homo sapiens.
IN T00949 Myf-5; clawed frog, Xenopus laevis.
IN T00522 Myf-6; human, Homo sapiens.
IN T00524 MyoD; clawed frog, Xenopus laevis.
IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T00527 MyoD; monkey, Cercopithecus aethiops.
IN T01128 MyoD; chick, Gallus gallus.
IN T00520 Myogenin; human, Homo sapiens.
XX
MX M00693 V$E12_Q6.
MX M00804 V$E2A_Q2.
MX M00973 V$E2A_Q6.
MX M07353 V$E2A_Q6_02.
MX M00002 V$E47_01.
MX M00071 V$E47_02.
MX M01034 V$EBOX_Q6_01.
MX M00222 V$HAND1E47_01.
MX M00929 V$MYOD_Q6_01.
MX M00066 V$TAL1ALPHAE47_01.
MX M00065 V$TAL1BETAE47_01.
XX
BS R04158.
BS R00913.
XX
DR TRANSPATH: MO000024920.
DR TRANSCOMPEL: C00031.
DR TRANSCOMPEL: C00035.
DR EMBL: X52078;
DR UniProtKB: P15923;
XX
RN [1]; RE0000670.
RX PUBMED: 1899229.
RA Ruezinsky D., Beckmann H., Kadesh T.
RT Modulation of the Igh enhancer's cell type through a genetic switch
RL Genes Dev. 5:29-37 (1991).
RN [2]; RE0002107.
RX PUBMED: 2308859.
RA Henthorn P., McCarrick-Walmsley R., Kadesch T.
RT Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor
RL Nucleic Acids Res. 18:677-677 (1990).
RN [3]; RE0002660.
RX PUBMED: 2105528.
RA Henthorn P., Kiledjian M., Kadesch T.
RT Two distinct transcription factors that bind the immunoglobulin enhancer muE5/kappaE2 motif
RL Science 247:467-470 (1990).
RN [4]; RE0002863.
RX PUBMED: 1944284.
RA Wilson R. B., Kiledjian M., Shen C.-P., Benezra R., Zwollo P., Dymecki S. M., Desiderio S. V., Kadesch T.
RT Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development
RL Mol. Cell. Biol. 11:6185-6191 (1991).
RN [5]; RE0003743.
RX PUBMED: 8065348.
RA Genetta T., Ruezinsky D., Kadesch T.
RT Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer
RL Mol. Cell. Biol. 14:6153-6163 (1994).
RN [6]; RE0012731.
RX PUBMED: 8628307.
RA Miyamoto A., Cui X., Naumovski L., Cleary M. L.
RT Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells
RL Mol. Cell. Biol. 16:2394-2401 (1996).
XX
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