TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00520 XX ID T00520 XX DT 20.11.1992 (created); ewi. DT 09.06.2011 (updated); spa. CO Copyright (C), QIAGEN. XX FA Myogenin XX SY Myf-4; MyoG; myogenin. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001943 MYOG; HGNC: MyoG. XX CL C0010; bHLH; XX SF Myogenin does not heterodimerize with any of the other myogenic factors [2]; SF HLH domain is involved in direct interactions with the C-terminus of Sp1 [7]; XX CP myogenic cells; skeletal muscle cells. XX FF activator; FF myogenic transcription factor; FF coexpressed with MyoD in the developing limb bud [6]; FF pre-existing MEF-2 activates Myogenin expression [4]; FF form a muscle-specific multiprotein transcriptional complex with SRF and Sp1 [7]; XX IN T00204 E12; human, Homo sapiens. IN T00207 E47; human, Homo sapiens. IN T01503 HTF4; human, Homo sapiens. IN T00432 ITF-1; human, Homo sapiens. IN T00433 ITF-2; human, Homo sapiens. IN T00722 pRb; human, Homo sapiens. IN T00759 Sp1; human, Homo sapiens. XX MX M00804 V$E2A_Q2. MX M00973 V$E2A_Q6. MX M01034 V$EBOX_Q6_01. MX M00929 V$MYOD_Q6_01. MX M00712 V$MYOGENIN_Q6. MX M02101 V$MYOGENIN_Q6_01. XX BS R02452. BS R02418. BS R02419. BS R35478. XX DR TRANSPATH: MO000024984. DR TRANSCOMPEL: C00432. DR UniProtKB: P15173; XX RN [1]; RE0000475. RX PUBMED: 2583111. RA Braun T., Bober E., Buschhausen-Denker G., Kotz S., Grzeschik K., Arnold H. H. RT Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products RL EMBO J. 8:3617-3625 (1989). RN [2]; RE0002108. RX PUBMED: 1945842. RA Braun T., Arnold H. H. RT The four helix-loop-helix proteins Myf3-Myf6 exhibit similar hetero-dimerization and DNA binding properties RL Nucleic Acids Res. 19:5645-5651 (1991). RN [3]; RE0002118. RX PUBMED: 2243772. RA Rosenthal N., Berglund E. B., Wentworth B. M., Donoghue M., Winter B., Bober E., Braun T., Arnold H.-H. RT A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factors RL Nucleic Acids Res. 18:6239 (1990). RN [4]; RE0003256. RX PUBMED: 8006037. RA Buchberger A., Ragge K., Arnold H.-H. RT The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF-2 RL J. Biol. Chem. 269:17289-17296 (1994). RN [5]; RE0003258. RX PUBMED: 1659574. RA Salminen A., Braun T., Buchberger A., Juers S., Winter B., Arnold H. H. RT Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signalling pathways involving G proteins RL J. Cell Biol. 115:905-917 (1991). RN [6]; RE0003410. RX PUBMED: 1652425. RA Ott M.-O., Bober E., Lyons G., Arnold H.-H., Buckingham M. RT Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo RL Development 111:1097-1107 (1991). RN [7]; RE0025127. RX PUBMED: 10082523. RA Biesiada E., Hamamori Y., Kedes L., Sartorelli V. RT Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. RL Mol. Cell. Biol. 19:2577-2584 (1999). RN [8]; RE0049236. RX PUBMED: 11073990. RA MacLellan W. R., Xiao G., Abdellatif M., Schneider M. D. RT A novel Rb- and p300-binding protein inhibits transactivation by MyoD. RL Mol. Cell. Biol. 20:8903-8915 (2000). XX //