AC T01503
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ID T01503
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DT 07.06.1995 (created); ewi.
DT 08.05.2013 (updated); hna.
CO Copyright (C), QIAGEN.
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FA HTF4
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SY HTF4; HTF4A; TCF-12.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004678 TCF12; HGNC: TCF12.
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CL C0010; bHLH; 1.2.1.0.3.
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SF class A type domain C-terminally adjacent to the bHLH motif;
SF may comprise a novel loop-helix motif in the trans-activating region as suggested by similarity with E2A and E2-2 gene products and Daughterless (Drosophila) [4];
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CP thymus, T-cell lines; lower in brain, kidney, ovary; moderate in lung; low in skeletal muscle [3].
CN heart, spleen, stomach [3].
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FF transcriptional activator, binding to E box elements [3];
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IN T00204 E12; human, Homo sapiens.
IN T01654 HEN1; human, Homo sapiens.
IN T00433 ITF-2; human, Homo sapiens.
IN T01619 MASH-1; mouse, Mus musculus.
IN T01620 MASH-1; human, Homo sapiens.
IN T00485 MASH-2; rat, Rattus norvegicus.
IN T00520 Myogenin; human, Homo sapiens.
IN T00528 myogenin; mouse, Mus musculus.
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MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M00698 V$HEB_Q6.
MX M02018 V$HTF4_Q2.
MX M04806 V$TCF12_01.
MX M04813 V$TCF12_02.
MX M04883 V$TCF12_03.
MX M04887 V$TCF12_04.
MX M04931 V$TCF12_05.
MX M04937 V$TCF12_06.
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BS R55928.
BS R55930.
BS R32486.
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DR TRANSPATH: MO000025717.
DR UniProtKB: Q99081;
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RN [1]; RE0002112.
RX PUBMED: 1886779.
RA Zhang Y., Babin J., Feldhaus A. L., Singh H., Sharp P. A., Bina M.
RT HTF4: A new human helix-loop-helix protein
RL Nucleic Acids Res. 19:4555-4555 (1991).
RN [2]; RE0002932.
RX PUBMED: 8289805.
RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. E., Hu J.-S., Kingston R. E., Baer R.
RT Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins
RL Mol. Cell. Biol. 14:1256-1265 (1994).
RN [3]; RE0003087.
RX PUBMED: 1312219.
RA Hu J.-S., Olson E. N., Kingston R. E.
RT HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
RL Mol. Cell. Biol. 12:1031-1042 (1992).
RN [4]; RE0003543.
RX PUBMED: 8423802.
RA Quong M. W., Massari M. E., Zwart R., Murre C.
RT A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
RL Mol. Cell. Biol. 13:792-800 (1993).
RN [5]; RE0003728.
RX PUBMED: 8355705.
RA Sawada S., Littman D. R.
RT A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
RL Mol. Cell. Biol. 13:5620-5628 (1993).
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