TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01503 XX ID T01503 XX DT 07.06.1995 (created); ewi. DT 08.05.2013 (updated); hna. CO Copyright (C), QIAGEN. XX FA HTF4 XX SY HTF4; HTF4A; TCF-12. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004678 TCF12; HGNC: TCF12. XX CL C0010; bHLH; XX SF class A type domain C-terminally adjacent to the bHLH motif; SF may comprise a novel loop-helix motif in the trans-activating region as suggested by similarity with E2A and E2-2 gene products and Daughterless (Drosophila) [4]; XX CP thymus, T-cell lines; lower in brain, kidney, ovary; moderate in lung; low in skeletal muscle [3]. CN heart, spleen, stomach [3]. XX FF transcriptional activator, binding to E box elements [3]; XX IN T00204 E12; human, Homo sapiens. IN T01654 HEN1; human, Homo sapiens. IN T00433 ITF-2; human, Homo sapiens. IN T01619 MASH-1; mouse, Mus musculus. IN T01620 MASH-1; human, Homo sapiens. IN T00485 MASH-2; rat, Rattus norvegicus. IN T00520 Myogenin; human, Homo sapiens. IN T00528 myogenin; mouse, Mus musculus. XX MX M00973 V$E2A_Q6. MX M01034 V$EBOX_Q6_01. MX M00698 V$HEB_Q6. MX M02018 V$HTF4_Q2. MX M04806 V$TCF12_01. MX M04813 V$TCF12_02. MX M04883 V$TCF12_03. MX M04887 V$TCF12_04. MX M04931 V$TCF12_05. MX M04937 V$TCF12_06. XX BS R55928. BS R55930. BS R32486. XX DR TRANSPATH: MO000025717. DR UniProtKB: Q99081; XX RN [1]; RE0002112. RX PUBMED: 1886779. RA Zhang Y., Babin J., Feldhaus A. L., Singh H., Sharp P. A., Bina M. RT HTF4: A new human helix-loop-helix protein RL Nucleic Acids Res. 19:4555-4555 (1991). RN [2]; RE0002932. RX PUBMED: 8289805. RA Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. E., Hu J.-S., Kingston R. E., Baer R. RT Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins RL Mol. Cell. Biol. 14:1256-1265 (1994). RN [3]; RE0003087. RX PUBMED: 1312219. RA Hu J.-S., Olson E. N., Kingston R. E. RT HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors RL Mol. Cell. Biol. 12:1031-1042 (1992). RN [4]; RE0003543. RX PUBMED: 8423802. RA Quong M. W., Massari M. E., Zwart R., Murre C. RT A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells RL Mol. Cell. Biol. 13:792-800 (1993). RN [5]; RE0003728. RX PUBMED: 8355705. RA Sawada S., Littman D. R. RT A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines RL Mol. Cell. Biol. 13:5620-5628 (1993). XX //