AC T00521
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ID T00521
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DT 21.10.1992 (created); ewi.
DT 09.06.2011 (updated); spa.
CO Copyright (C), QIAGEN.
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FA Myf-5
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SY Myf-5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003932 MYF5; HGNC: MYF5.
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CL C0010; bHLH; 1.2.2.1.3.
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SF heterodimerization with E12 enhances DNA-binding and transcription activation [7];
SF no heterodimerization with other myogenic factors [4];
SF N- and C-terminal regions have to cooperate for full trans-activation [7];
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CP myogenic cells; dorsal region of the somites adjacent to the neural tube at CS10 [8]; myotomes and dermomyotomes (CS12) [8].
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FF muscle-specific transcription activator [2];
FF induces myogenic differentiation in vitro and in vivo [2];
FF different expression pattern than MyoD [1];
FF down-regulated by PKA [5];
FF down-regulated by E1A [6];
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IN T00204 E12; human, Homo sapiens.
IN T00675 E12; rat, Rattus norvegicus.
IN T01787 E12; clawed frog, Xenopus laevis.
IN T00207 E47; human, Homo sapiens.
IN T00403 Id1; mouse, Mus musculus.
IN T00432 ITF-1; human, Homo sapiens.
IN T00433 ITF-2; human, Homo sapiens.
IN T00521 Myf-5; human, Homo sapiens.
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MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M03880 V$MYF5_Q6.
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BS R35478.
BS R02898.
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DR TRANSPATH: MO000024985.
DR UniProtKB: P13349;
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RN [1]; RE0000475.
RX PUBMED: 2583111.
RA Braun T., Bober E., Buschhausen-Denker G., Kotz S., Grzeschik K., Arnold H. H.
RT Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products
RL EMBO J. 8:3617-3625 (1989).
RN [2]; RE0000476.
RX PUBMED: 2721498.
RA Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H. H.
RT A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts
RL EMBO J. 8:701-709 (1989).
RN [3]; RE0001863.
RX PUBMED: 2385294.
RA Braun T., Winter B., Bober E., Arnold H. H.
RT Transcriptional activation domain of the muscle-specific gene-regulatory protein myf5
RL Nature 346:663-665 (1990).
RN [4]; RE0002108.
RX PUBMED: 1945842.
RA Braun T., Arnold H. H.
RT The four helix-loop-helix proteins Myf3-Myf6 exhibit similar hetero-dimerization and DNA binding properties
RL Nucleic Acids Res. 19:5645-5651 (1991).
RN [5]; RE0003234.
RX PUBMED: 8387507.
RA Winter B., Braun T., Arnold H. H.
RT cAMP-dependent protein kinase represses myogenic differentiation and the activity of the muscle-specific helix-loop-helix transcription factors Myf-5 and MyoD
RL J. Biol. Chem. 13:9869-9878 (1993).
RN [6]; RE0003260.
RX PUBMED: 1315706.
RA Braun T., Bober E., Arnold H. H.
RT Inhibition of muscle differentiation by the adenovirus E1a protein: Repression of the transcriptional activating function of the HLH protein Myf-5
RL Genes Dev. 6:888-902 (1992).
RN [7]; RE0003261.
RX PUBMED: 1582413.
RA Winter B., Braun T., Arnold H.-H.
RT Co-operativity of functional domains in the muscle-specific transcription factor Myf-5
RL EMBO J. 11:1843-1855 (1992).
RN [8]; RE0036083.
RX PUBMED: 12500905.
RA Fougerousse F., Durand M., Lopez S., Suel L., Demignon J., Thornton C., Ozaki H., Kawakami K., Barbet P., Beckmann J. S., Maire P.
RT Six and Eya expression during human somitogenesis and MyoD gene family activation.
RL J. Muscle Res. Cell. Motil. 23:255-264 (2002).
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