AC T01212
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ID T01212
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DT 22.10.1992 (created); ewi.
DT 29.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
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FA Id2
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SY Id-2; inhibitor of DNA-binding 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003949 ID2; HGNC: ID2.
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CL C0011; HLH; 1.2.8.0.2.
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SF no basic (=DNA-binding) domain;
SF dimerizes with some bHLH factors and interacts with Rb through the Id2 HLH-domain [3];
SF mutation of codon 37 leads to a truncated variant (Id2B) [4];
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CP undifferentiated cells; much higher levels in embryonic than in adult brain, heart, kidney, lung; low in embryonic or adult liver [1].
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FF inhibits those bHLH proteins it heterodimerizes with;
FF antagonizes Rb and thus promotes cell proliferation [3];
FF down-regulated in confluent cells and upon induction of differentiation by retinoic acid [1];
FF distinct elements of the Id2 promoter are responsible for expression in either muscle or non-muscle cells [2];
FF expression is enhanced by serum in two phases after 2h and after 12h (early passage cells), only the first peak is seen in late passage cells [5];
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IN T00204 E12; human, Homo sapiens.
IN T00207 E47; human, Homo sapiens.
IN T00674 E47; rat, Rattus norvegicus.
IN T01788 E47; mouse, Mus musculus.
IN T00403 Id1; mouse, Mus musculus.
IN T00433 ITF-2; human, Homo sapiens.
IN T01659 m3; mouse, Mus musculus.
IN T00524 MyoD; clawed frog, Xenopus laevis.
IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T00527 MyoD; monkey, Cercopithecus aethiops.
IN T01128 MyoD; chick, Gallus gallus.
IN T00722 pRb; human, Homo sapiens.
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DR TRANSPATH: MO000025501.
DR UniProtKB: Q02363;
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RN [1]; RE0002425.
RX PUBMED: 1741406.
RA Biggs J., Murphy E. V., Israel M. A.
RT A human Id-like helix-loop-helix protein expressed during early development
RL Proc. Natl. Acad. Sci. USA 89:1512-1516 (1992).
RN [2]; RE0004172.
RX PUBMED: 7983058.
RA Kurabayashi M., Dutta S., Kedes L.
RT Serum-inducible factors binding to an activating transcription factor motif regulate transcription of the Id2A promoter during myogenic differentiation
RL J. Biol. Chem. 269:31162-31170 (1994).
RN [3]; RE0004173.
RX PUBMED: 7926730.
RA Iavarone A., Garg P., Lasorella A., Hsu J., Israel M. A.
RT The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein
RL Genes Dev. 8:1270-1284 (1994).
RN [4]; RE0004174.
RX PUBMED: 8224921.
RA Kurabayashi M., Jeyaseelan R., Kedes L.
RT Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2
RL Gene 133:305-306 (1993).
RN [5]; RE0005842.
RX PUBMED: 8294468.
RA Hara E., Yamaguchi T., Nojima H., Ide T., Campisi J., Okayama H., Oda K.
RT Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
RL J. Biol. Chem. 269:2139-2145 (1994).
RN [6]; RE0017215.
RX PUBMED: 9584154.
RA Massari M. E., Rivera R. R., Voland J. R., Quong M. W., Breit T. M., van Dongen J. J., de Smit O., Murre C.
RT Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes
RL Mol. Cell. Biol. 18:3130-3139 (1998).
RN [7]; RE0047963.
RX PUBMED: 11134340.
RA Roberts E. C., Deed R. W., Inoue T., Norton J. D., Sharrocks A. D.
RT Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.
RL Mol. Cell. Biol. 21:524-533 (2001).
RN [8]; RE0049099.
RX PUBMED: 10502414.
RA Law S. F., Zhang Y. Z., Fashena S. J., Toby G., Estojak J., Golemis E. A.
RT Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain.
RL Exp. Cell Res. 252:224-235 (1999).
RN [9]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
RN [10]; RE0069431.
RX PUBMED: 18488021.
RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A.
RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
RL Nat. Cell Biol. 10:643-653 (2008).
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