AC T00404
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ID T00404
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DT 22.10.1992 (created); ewi.
DT 29.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
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FA Id2
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SY Id-2; inhibitor of DNA-binding 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006258 Id2.
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CL C0011; HLH; 1.2.8.0.2.
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SF no basic (=DNA-binding) domain;
SF heterodimerizes with several bHLH factors, but not with USF, TFE-3, AP-4, or Id1 [1];
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CP undifferentiated cells.
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FF inhibits bHLH proteins and myeloid differentiation;
FF promotes cell proliferation [3];
FF in different neuronal cell lines, Id2 may increase, decrease, or remain constant during differentiation [4];
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IN T00204 E12; human, Homo sapiens.
IN T01786 E12; mouse, Mus musculus.
IN T00207 E47; human, Homo sapiens.
IN T00674 E47; rat, Rattus norvegicus.
IN T01788 E47; mouse, Mus musculus.
IN T00403 Id1; mouse, Mus musculus.
IN T01659 m3; mouse, Mus musculus.
IN T00524 MyoD; clawed frog, Xenopus laevis.
IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T00527 MyoD; monkey, Cercopithecus aethiops.
IN T01128 MyoD; chick, Gallus gallus.
IN T05852 OLIG2; mouse, Mus musculus.
IN T05853 Oligo1; mouse, Mus musculus.
IN T02333 SNA; mouse, Mus musculus.
IN T15307 SNA; mouse, Mus musculus.
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MX M07993 V$ID2_01.
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DR TRANSPATH: MO000024900.
DR UniProtKB: P41136;
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RN [1]; RE0001511.
RX PUBMED: 1922066.
RA Sun X.-H., Copeland N. G., Jenkins N. A., Baltimore D.
RT Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
RL Mol. Cell. Biol. 11:5603-5611 (1991).
RN [2]; RE0004019.
RX PUBMED: 8383120.
RA Staudinger J., Perry M., Elledge S. J., Olson E. N.
RT Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system
RL J. Biol. Chem. 268:4608-4611 (1993).
RN [3]; RE0004168.
RX PUBMED: 8197168.
RA Barone M. V., Pepperkok R., Peverali F. A., Philipson L.
RT Id proteins control growth induction in mammalian cells
RL Proc. Natl. Acad. Sci. USA 91:4985-4988 (1994).
RN [4]; RE0004171.
RX PUBMED: 8224536.
RA Neuman T., Keen A., Zuber M. X., Kristjansson G. I., Gruss P., Nornes H. O.
RT Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse
RL Dev. Biol. 160:186-195 (1993).
RN [5]; RE0049091.
RX PUBMED: 12200424.
RA Heng J. I., Tan S. S.
RT Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain.
RL J. Biol. Chem. 277:43152-43159 (2002).
RN [6]; RE0049142.
RX PUBMED: 15280210.
RA Samanta J., Kessler J. A.
RT Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation.
RL Development 131:4131-4142 (2004).
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