AC T05852
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ID T05852
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DT 05.02.2004 (created); elf.
DT 09.06.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA OLIG2
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SY BHLHB1; Olg-2; OLIG2; Oligo2; oligodendrocyte transcription factor 2; RK17.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009159 Olig2.
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CL C0010; bHLH; 1.2.3.4.14.
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CP nervous tissue, ventral ventricular zone of spinal cord, oligodendrocyte progenitor [2]; mature oligodendrocytes [3]; nucleus of oligodendrocytes and their progenitors in postnatal day 1 mouse brain, Olig2 continues to be nuclear at all developmental stages [3]; corpus callosum, fornix, spinal cord [3] [2] [3].
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FF oligodendrogenesis [2];
FF specification of oligodendrocytes and motor neurons during vertebrate embryogenesis [3];
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IN T00404 Id2; mouse, Mus musculus.
IN T01658 IDB4; mouse, Mus musculus.
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DR TRANSPATH: MO000039160.
DR UniProtKB: Q9EQW6;
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RN [1]; RE0023814.
RX PUBMED: 10719889.
RA Zhou Q., Wang S., Anderson D. J.
RT Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors.
RL Neuron 25:331-343 (2000).
RN [2]; RE0023815.
RX PUBMED: 11091082.
RA Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R., Nakafuku M., Nabeshima Y.
RT Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.
RL Mech. Dev. 99:143-148 (2000).
RN [3]; RE0025491.
RX PUBMED: 15604411.
RA Arnett H. A., Fancy S. P., Alberta J. A., Zhao C., Plant S. R., Kaing S., Raine C. S., Rowitch D. H., Franklin R. J., Stiles C. D.
RT bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
RL Science 306:2111-2115 (2004).
RN [4]; RE0049142.
RX PUBMED: 15280210.
RA Samanta J., Kessler J. A.
RT Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation.
RL Development 131:4131-4142 (2004).
RN [5]; RE0066684.
RX PUBMED: 19223390.
RA Patterson V. L., Damrau C., Paudyal A., Reeve B., Grimes D. T., Stewart M. E., Williams D. J., Siggers P., Greenfield A., Murdoch J. N.
RT Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.
RL Hum. Mol. Genet. 18:1719-1739 (2009).
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