AC T01658
XX
ID T01658
XX
DT 05.02.1996 (created); ewi.
DT 30.04.2009 (updated); bjo.
CO Copyright (C), QIAGEN.
XX
FA IDB4
XX
SY inhibitor of DNA-binding 4.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006260 Id4.
XX
CL C0011; HLH; 1.2.8.0.4.
XX
SF IDB4 lacks the basic DNA-binding (sub)domain;
XX
CP low in fetal liver; high levels in adult testis, kidney, brain, low in bone marrow, spleen [1].
CN adult liver (barely detectable) [1].
EX bone marrow,,,adult; low; Northern blot; RNA (undefined); [1].
EX brain,,,adult; high; Northern blot; RNA (undefined); [1].
EX kidney (right and left),,,adult; high; Northern blot; RNA (undefined); [1].
EX liver,,,adult; none; Northern blot; RNA (undefined); [1].
EX liver,,,fetal; low; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 15; detectable; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 16; detectable; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 17; detectable; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 18; detectable; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 19; detectable; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 20; detectable; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 21; detectable; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 22; detectable; Northern blot; RNA (undefined); [1].
EX spleen,,,adult; low; Northern blot; RNA (undefined); [1].
EX testis (right and left),,,adult; high; Northern blot; RNA (undefined); [1].
XX
FF inhibits DNA-binding of E47 and MyoD/E47 [1];
FF it is upregulated during embryogenesis up to day 13.5 [1];
XX
IN T00207 E47; human, Homo sapiens.
IN T09198 Id3; mouse, Mus musculus.
IN T05852 OLIG2; mouse, Mus musculus.
IN T05853 Oligo1; mouse, Mus musculus.
XX
DR TRANSPATH: MO000025845.
DR UniProtKB: P41139;
XX
RN [1]; RE0003696.
RX PUBMED: 8139914.
RA Riechmann V., van Cruechten I., Sablitzky F.
RT The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3
RL Nucleic Acids Res. 22:749-755 (1994).
RN [2]; RE0012509.
RX PUBMED: 8759016.
RA Loveys D. A., Streiff M. B., Kato G. J.
RT E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the ld3 protein
RL Nucleic Acids Res. 24:2813-2820 (1996).
RN [3]; RE0049142.
RX PUBMED: 15280210.
RA Samanta J., Kessler J. A.
RT Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation.
RL Development 131:4131-4142 (2004).
XX
//