AC T15307
XX
ID T15307
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DT 22.10.2008 (created); pum.
DT 29.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
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FA SNA
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SY Sna; SNAI1; snail homolog 1 (Drosophila); snail protein homolog; Snail1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006740 Snai1.
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CL C0001; CH.
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SZ 264 AA; 29.2 kDa (cDNA) (calc.).
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SQ MPRSFLVRKPSDPRRKPNYSELQDACVEFTFQQPYDQAHLLAAIPPPEVLNPAASLPTLI
SQ WDSLLVPQVRPVAWATLPLRESPKAVELTSLSDEDSGKSSQPPSPPSPAPSSFSSTSASS
SQ LEAEAFIAFPGLGQLPKQLARLSVAKDPQSRKIFNCKYCNKEYLSLGALKMHIRSHTLPC
SQ VCTTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQA
SQ CARTFSRMSLLHKHQESGCSGGPR
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SC Swiss-Prot#Q02085
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FT 154 176 
PF00096; zf-C2H2.
FT 154 176 
SM00355; c2h2final6.
FT 154 177 
PS50157; ZINC_FINGER_C2H2_2.
FT 180 202 
PF00096; zf-C2H2.
FT 180 202 
SM00355; c2h2final6.
FT 180 207 
PS50157; ZINC_FINGER_C2H2_2.
FT 208 230 
PF00096; zf-C2H2.
FT 208 230 
SM00355; c2h2final6.
FT 208 235 
PS50157; ZINC_FINGER_C2H2_2.
FT 236 256 
SM00355; c2h2final6.
FT 236 259 PF00096; zf-C2H2.
FT 236 264 PS50157; ZINC_FINGER_C2H2_2.
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FF Zinc finger domain and amino terminal SNAG domain are required for Snail repressive activity at the Cdh1 gene promoter [5];
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IN T14419 Id1; human, Homo sapiens.
IN T00404 Id2; mouse, Mus musculus.
IN T09187 Id2; human, Homo sapiens.
IN T10004 Id2; mouse, Mus musculus.
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MX M03566 V$SNA_Q4.
MX M07430 V$SNA_Q6.
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BS R37440.
BS R40849.
BS R71696.
BS R40934.
BS R26899.
BS R37450.
BS R40925.
BS R40895.
XX
DR TRANSPATH: MO000143697.
DR EMBL: M95604;
DR UniProtKB: Q02085;
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RN [1]; RE0006526.
RX PUBMED: 1295727.
RA Smith D. E., Del Amo F. F., Gridley T.
RT Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development
RL Development 116:1033-1039 (1992).
RN [2]; RE0014820.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/SNA.htm
RL Internet : (1996).
RN [3]; RE0067519.
RX PUBMED: 19955572.
RA Vinas-Castells R., Beltran M., Valls G., Gomez I., Garcia J. M., Montserrat-Sentis B., Baulida J., Bonilla F., de Herreros A. G., Diaz V. M.
RT The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.
RL J. Biol. Chem. 285:3794-3805 (2010).
RN [4]; RE0070143.
RX PUBMED: 19923321.
RA MacPherson M. R., Molina P., Souchelnytskyi S., Wernstedt C., Martin-Perez J., Portillo F., Cano A.
RT Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.
RL Mol. Biol. Cell 21:244-253 (2010).
RN [5]; RE0027458.
RX PUBMED: 10655587.
RA Batlle E., Sancho E., Franci C., Dominguez D., Monfar M., Baulida J., Garcia de Herreros A.
RT The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.
RL Nat. Cell Biol. 2:84-9 (2000).
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