AC T01807
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ID T01807
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DT 14.05.1996 (created); ewi.
DT 04.04.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Id1
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SY Id; Id1; ID125A; Idb1; Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation); inhibitor of DNA-binding 1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014484 Id1.
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CL C0011; HLH.
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SZ 148 AA; 15.6 kDa (cDNA) (calc.).
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SQ MKVASSSAAATAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGTRLPALLDEQQVNVLLY
SQ DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVATAGARGLPVRA
SQ PLSTLNGEISALAAEAACVPADDRILCR
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SC conceptually translated from EMBL/GenBank/DDBJ #D10862
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FT 42 99 
PS50888; HLH.
FT 44 99 
PF00010; Helix-loop-helix DNA-binding domain.
FT 49 104 
SM00353; finulus.
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SF no basic DNA-binding domain;
SF a longer splice variant comprises 164 AA [4];
SF conflict: Ala-113 is Gly in Id1 (164 AA form);
SF homodimerization (KD = 5.3 uM) and homotetramerization (KD = 0.36 uM) [1];
SF avidly binding to MyoD (KD = 0.7 uM, KD = 0.01 uM) [1];
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CP undifferentiated cells.
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FF inhibitor of bHLH proteins;
FF although generally being present in undifferentiated cells, it has been found functional in pheochromocytoma cells (PC12) after induction of differentiation by NGF [2];
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IN T00674 E47; rat, Rattus norvegicus.
IN T00433 ITF-2; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
IN T09106 RelA-p65; mouse, Mus musculus.
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DR TRANSPATH: MO000025941.
DR EMBL: D10862;
DR UniProtKB: P41135-2;
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RN [1]; RE0003415.
RX PUBMED: 8248126.
RA Fairman R., Beran-Steed R. K., Anthony-Cahill S. J., Lear J. D., Stafford III W. F., DeGrado W. F., Benfield P. A., Brenner S. L.
RT Multiple oligomeric states regulate the DNA binding of helix-loop-helix proteins
RL Proc. Natl. Acad. Sci. USA 90:10429-10433 (1993).
RN [2]; RE0003541.
RX PUBMED: 7623812.
RA Einarson M. B., Chao M. V.
RT Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells
RL Mol. Cell. Biol. 15:4175-4183 (1995).
RN [3]; RE0004162.
RX PUBMED: 1584793.
RA Kawaguchi N., DeLuca H. F., Noda M.
RT Id gene expression and its suppression by 1,25-dihydroxyvitamin D3 in rat osteoblastic cells
RL Proc. Natl. Acad. Sci. USA 89:4569-4572 (1992).
RN [4]; RE0004166.
RX PUBMED: 8106493.
RA Springhorn J. P., Singh K., Kelly R.A., Smith T. W.
RT Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization
RL J. Biol. Chem. 269:5132-5136 (1994).
RN [5]; RE0004167.
RX PUBMED: 7908517.
RA Nagata Y., Todokoro K.
RT Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation
RL Biochem. Biophys. Res. Commun. 199:1355-1362 (1994).
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