AC T09106
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ID T09106
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DT 22.06.2006 (created); jma.
DT 04.04.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA RelA-p65
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SY NF-kappaB (p65); Rel-A; RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009183 Rela.
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CL C0020; Rel; 6.1.1.2.1.1.
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SZ 549 AA; 60.2 kDa (cDNA) (calc.), 65 kDa (SDS)
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SQ MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
SQ IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQC
SQ VKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLS
SQ HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
SQ QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
SQ KRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINF
SQ DEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLS
SQ APVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQG
SQ VSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDF
SQ SALLSQISS
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SC Swiss-Prot#Q04207-1
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FT 16 190 
PS50254; REL_2.
FT 21 186 
PF00554; Rel homology domain (RHD).
FT 193 289 
SM00429; iptmega2.
FT 194 289 
PF01833; IPT/TIG domain.
FT 457 482 
trans-activation domain 1' (TA1', by homology) [5].
FT 524 549 
trans-activation domain 1 (TA1, by homology) [5].
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IN T01807 Id1; rat, Rattus norvegicus.
IN T14419 Id1; human, Homo sapiens.
IN T24880 Id2; rat, Rattus norvegicus.
IN T10032 Id3; rat, Rattus norvegicus.
IN T09437 NF-kappaB1; mouse, Mus musculus.
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MX M00052 V$NFKAPPAB65_01.
MX M00054 V$NFKAPPAB_01.
MX M00774 V$NFKB_Q6_01.
MX M03563 V$RELA_Q6.
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BS R05858.
BS R05859.
BS R05860.
BS R05861.
BS R05862.
BS R05863.
BS R05864.
BS R05865.
BS R05866.
BS R05867.
BS R05868.
BS R05869.
BS R05870.
BS R05871.
BS R05872.
BS R05873.
BS R05874.
BS R05875.
BS R14652.
BS R14655.
BS R14483.
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DR TRANSPATH: MO000083492.
DR EMBL: M61909; MMNFKP65.
DR UniProtKB: Q04207-1;
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RN [1]; RE0000176.
RX PUBMED: 2001591.
RA Nolan G. P., Gosh S., Liou H.-C., Tempst P., Baltimore D.
RT DNA binding and IkappaB inhibition of the cloned p65 subunit of NF-kappaB, a rel-related polypeptide
RL Cell 64:961-969 (1991).
RN [2]; RE0000285.
RX PUBMED: 3076097.
RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D.
RT Phorbol-ester-induced activation of the NF-kappaB transcription factor involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor complex
RL Cold Spring Harb. Symp. Quant. Biol. 53:789-798 (1988).
RN [3]; RE0001374.
RX PUBMED: 2796988.
RA Gustafson T. A., Kedes L.
RT Identification of Multiple Proteins That Interact with Functional Regions of the Human Cardiac alpha-Actin Promoter
RL Mol. Cell. Biol. 9:3269-3283 (1989).
RN [4]; RE0001632.
RX PUBMED: 2548081.
RA Shirakawa F., Mizel S. B.
RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C
RL Mol. Cell. Biol. 9:2424-2430 (1991).
RN [5]; RE0003823.
RX PUBMED: 7797554.
RA Schmitz M. L., dos Santos Silva M. A., Baeuerle P. A.
RT Transactivation domain 2 (TA2) of p65 NF-kappaB
RL J. Biol. Chem. 270:15576-15584 (1995).
RN [6]; RE0004518.
RX PUBMED: 1577272.
RA Fujita T., Nolan G. P., Ghosh S., Baltimore D.
RT Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappaB
RL Genes Dev. 6:775-787 (1992).
RN [7]; RE0004547.
RX PUBMED: 7603567.
RA Beg A. A., Sha W. C., Bronson R. T., Ghosh S., Baltimore D.
RT Embryonic lethality and liver degeneration in mice lacking the ReIA component of NF-kappaB
RL Nature 376:167-170 (1995).
RN [8]; RE0004550.
RX PUBMED: 7867065.
RA Thompson J. E., Phillips R. J., Erdjument-Bromage H., Tempst P., Ghosh S.
RT IkappaB-beta regulates the persistent response in a biphasic activation of NF-kappaB
RL Cell 80:573-582 (1995).
RN [9]; RE0004553.
RX PUBMED: 1299224.
RA Kitajima I., Shinohara T., Bilakovics J., Brown D. A., Xu X., Nerenberg M.
RT Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappaB
RL Science 258:1792-1795 (1992).
RN [10]; RE0006254.
RX PUBMED: 8234276.
RA Matsusaka T., Fujikawa K., Nishio Y., Mukaida N., Matsushima K., Kishimoto T., Akira S.
RT Transcription factors NF-IL6 and NF-kappaB synergistically activate transcription of the inflammatory cytokines interleukin 6 and interleukin 8
RL Proc. Natl. Acad. Sci. USA 90:10193-10197 (1993).
RN [11]; RE0025411.
RX PUBMED: 15155743.
RA Anest V., Cogswell P. C., Baldwin AS J. r.
RT IkappaB kinase alpha and p65/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IkappaBalpha degradation.
RL J. Biol. Chem. 279:31183-31189 (2004).
RN [12]; RE0054833.
RX PUBMED: 17690092.
RA Lou H., Kaplowitz N.
RT Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms.
RL J. Biol. Chem. 282:29470-29481 (2007).
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