AC T00241
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ID T00241
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DT 09.11.1992 (created); ewi.
DT 29.02.2016 (updated); ros.
CO Copyright (C), QIAGEN.
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FA Egr-1
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SY AT225; early growth response 1; early growth response protein 1; Early Growth Responsive factor 1; Egr-1; EGR1; ETR103; G0S30; Krox-24; NGFI-A; TIS-8; TIS8; ZIF-268; zif268; ZNF225.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002144 EGR1; HGNC: EGR1.
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CL C0001; CH; 2.3.1.3.1.
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SF 3 zinc finger motifs [1];
SF S/G, S/P [1];
SF the existence of a repressor domain within the C-terminal part of the protein has been suggested [5];
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CP T-cells; troglitazone (TGZ) treated HCT-116 cells [14]; HUVEC [16]; PMA treated C2BBe1 cells [15]; UV, PMA or serum stimulated glioblastoma cell lines: U251, T98G, U-373MG and U-87MG (cells in quiescent stage) [11]; IL-1 alpha treated ECV304 cells [8]; bFGF stimulated Hep3B cells [7]; TPA treated K-562 cells [10].
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FF activator;
FF transiently expressed after mitogenic stimulation [1];
FF constitutively expressed after infection with HTLV-I or HTLV-II [1];
FF may be induced by PMA [2];
FF participates in down-regulation of GATA-1 and in the up-regulation of the megakaryocyte-specific gene CD41a [2];
FF immediate early gene in T-cell activation, mRNA is induced 30 min after stimulation [3];
FF can regulate transcription synergistically with NF-ATc [5] [4];
FF in several cases, binding sites for Egr-1 coincide with those for Sp1, for example in IL-2 promoter [3];
FF Egr-1 is important for the regulation of ELK-1 transcription in differentiating monocytes [6];
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IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T14513 beta-catenin; Mammalia.
IN T00433 ITF-2; human, Homo sapiens.
IN T16141 LEF-1; human, Homo sapiens.
IN T05127 Mam-1; human, Homo sapiens.
IN T11025 NFATc1; Mammalia.
IN T11024 NFATc2; Mammalia.
IN T00759 Sp1; human, Homo sapiens.
IN T01560 SREBP-2; human, Homo sapiens.
IN T22876 YAP; human, Homo sapiens.
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MX M00243 V$EGR1_01.
MX M01972 V$EGR1_02.
MX M03896 V$EGR1_07.
MX M04797 V$EGR1_09.
MX M04832 V$EGR1_10.
MX M04869 V$EGR1_11.
MX M04892 V$EGR1_12.
MX M04918 V$EGR1_13.
MX M04950 V$EGR1_15.
MX M07208 V$EGR1_16.
MX M07354 V$EGR1_Q3.
MX M01873 V$EGR1_Q6.
MX M08878 V$EGR_Q3.
MX M00807 V$EGR_Q6.
MX M00982 V$KROX_Q6.
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BS R20984.
BS R17111.
BS R23632.
BS R24245.
BS R24870.
BS R24948.
BS R25085.
BS R37367.
BS R19606.
BS R20852.
BS R20856.
BS R21725.
BS R29591.
BS R61120.
BS R66946.
BS R28564.
BS R37704.
BS R64961.
BS R26893.
BS R41939.
BS R24190.
BS R69080.
BS R69081.
BS R24730.
BS R24733.
BS R22669.
BS R39401.
BS R08182.
BS R25006.
BS R34174.
BS R67242.
BS R20418.
BS R58660.
BS R33405.
BS R33406.
BS R33407.
BS R36015.
BS R70118.
BS R16963.
BS R32853.
BS R60012.
BS R32429.
BS R24898.
BS R32150.
BS R32154.
BS R24693.
BS R24695.
BS R24238.
BS R24501.
BS R24913.
BS R14539.
BS R31815.
BS R23903.
BS R30528.
BS R31121.
BS R32871.
BS R32874.
BS R31346.
BS R26626.
BS R31202.
BS R33974.
BS R33975.
BS R23889.
BS R28594.
BS R28595.
BS R28596.
BS R68887.
BS R32016.
BS R24139.
BS R24140.
BS R04907.
BS R69083.
BS R69085.
BS R69086.
BS R34429.
BS R57073.
BS R59933.
BS R25112.
BS R56089.
BS R15703.
BS R32796.
BS R58732.
BS R69113.
BS R69114.
BS R30147.
BS R30152.
BS R24883.
BS R24887.
BS R24889.
BS R22372.
BS R24762.
BS R24219.
BS R62542.
BS R57070.
BS R58537.
BS R71342.
BS R24608.
BS R31842.
BS R21167.
BS R69701.
BS R24846.
BS R31103.
BS R17109.
BS R68693.
BS R68796.
BS R68799.
BS R68802.
BS R62544.
BS R24612.
BS R24638.
BS R24456.
BS R24458.
BS R71616.
BS R61551.
BS R21790.
BS R30577.
BS R32080.
BS R66015.
BS R66026.
BS R31057.
BS R31061.
BS R31064.
BS R58333.
BS R58335.
BS R58337.
BS R58340.
BS R58343.
BS R65307.
BS R62988.
BS R14693.
BS R14703.
BS R14704.
BS R14632.
BS R71213.
BS R31074.
BS R60607.
BS R25224.
BS R01615.
BS R25639.
BS R65523.
BS R34258.
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DR TRANSPATH: MO000017914.
DR TRANSCOMPEL: C00356.
DR TRANSCOMPEL: C00384.
DR UniProtKB: P18146; EGR1_HUMAN.
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RN [1]; RE0002677.
RX PUBMED: 2110381.
RA Wright J. J., Gunter K. C., Mitsuya H., Irving St. G., Kelly K., Siebenlist U.
RT Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells
RL Science 248:588-591 (1990).
RN [2]; RE0006699.
RX PUBMED: 7983016.
RA Cheng T., Wang Y., Dai W.
RT Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells
RL J. Biol. Chem. 269:30848-30853 (1994).
RN [3]; RE0011295.
RX PUBMED: 7673240.
RA Skerka C., Decker E. L., Zipfel P. F.
RT A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1
RL J. Biol. Chem. 270:22500-22506 (1995).
RN [4]; RE0017818.
RX PUBMED: 10508276.
RA Li-Weber M., Laur O., Krammer P. H.
RT Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation.
RL Eur. J. Immunol. 29:3017-3027 (1999).
RN [5]; RE0022849.
RX PUBMED: 9756940.
RA Decker E. L., Skerka C., Zipfel P. F.
RT The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells.
RL J. Biol. Chem. 273:26923-26930 (1998).
RN [6]; RE0024298.
RX PUBMED: 9880555.
RA Lehmann U., Brocke P., Dittmer J., Nordheim A.
RT Characterization of the human elk-1 promoter. Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes.
RL J. Biol. Chem. 274:1736-1744 (1999).
RN [7]; RE0027009.
RX PUBMED: 9178905.
RA Wang D., Mayo M. W., Baldwin A. S. Jr.
RT Basic fibroblast growth factor transcriptional autoregulation requires EGR-1.
RL Oncogene 14:2291-9 (1997).
RN [8]; RE0027084.
RX PUBMED: 10202038.
RA Fitzgerald K. A., O'Neill L. A.
RT Characterization of CD44 induction by IL-1: a critical role for Egr-1.
RL J. Immunol. 162:4920-7 (1999).
RN [9]; RE0030092.
RX PUBMED: 12560487.
RA Decker E. L., Nehmann N., Kampen E., Eibel H., Zipfel P. F., Skerka C.
RT Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.
RL Nucleic Acids Res. 31:911-21 (2003).
RN [10]; RE0034687.
RX PUBMED: 10392899.
RA McCoy C., McGee S. B., Cornwell M. M.
RT The Wilms' tumor suppressor, WT1, inhibits 12-O-tetradecanoylphorbol-13-acetate activation of the multidrug resistance-1 promoter.
RL Cell Growth Differ. 10:377-86 (1999).
RN [11]; RE0045368.
RX PUBMED: 10783396.
RA Liu C., Yao J., Mercola D., Adamson E.
RT The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251
RL J. Biol. Chem. 275:20315-23 (2000).
RN [12]; RE0048464.
RX PUBMED: 16702209.
RA Chen S. J., Ning H., Ishida W., Sodin-Semrl S., Takagawa S., Mori Y., Varga J.
RT The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression.
RL J. Biol. Chem. 281:21183-21197 (2006).
RN [13]; RE0049003.
RX PUBMED: 12890669.
RA Yang S. Z., Abdulkadir S. A.
RT Early growth response gene 1 modulates androgen receptor signaling in prostate carcinoma cells.
RL J. Biol. Chem. 278:39906-39911 (2003).
RN [14]; RE0052319.
RX PUBMED: 12475986.
RA Baek S. J., Wilson L. C., Hsi L. C., Eling T. E.
RT Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
RL J. Biol. Chem. 278:5845-5853 (2003).
RN [15]; RE0053242.
RX PUBMED: 15976391.
RA Malakooti J., Sandoval R., Memark V. C., Dudeja P. K., Ramaswamy K.
RT Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate.
RL Am. J. Physiol. Gastrointest. Liver Physiol. 289:G653-63 (2005).
RN [16]; RE0053454.
RX PUBMED: 17675290.
RA Wang J., Mahmud S. A., Bitterman P. B., Huo Y., Slungaard A.
RT Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.
RL J. Biol. Chem. 282:28408-28418 (2007).
RN [17]; RE0055381.
RX PUBMED: 15003938.
RA Hjoberg J., Le L., Imrich A., Subramaniam V., Mathew S. I., Vallone J., Haley K. J., Green F. H., Shore S. A., Silverman E. S.
RT Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle.
RL Am. J. Physiol. Lung Cell. Mol. Physiol. 286:L817-25 (2004).
RN [18]; RE0066799.
RX PUBMED: 20448047.
RA Patel N., Kalra V. K.
RT Placenta growth factor (PlGF)-induced early growth response 1 (Egr-1) regulates hypoxia inducible factor-1{alpha} (HIF-1{alpha}) in endothelial cells.
RL J. Biol. Chem. 285:20570-20579 (2010).
RN [19]; RE0067064.
RX PUBMED: 20515787.
RA Zhang J., Valianou M., Cheng J. D.
RT Identification and characterization of the promoter of fibroblast activation protein.
RL Front Biosci (Elite Ed). 2:1154-1163 (2010).
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