TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00241 XX ID T00241 XX DT 09.11.1992 (created); ewi. DT 29.02.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA Egr-1 XX SY AT225; early growth response 1; early growth response protein 1; Early Growth Responsive factor 1; Egr-1; EGR1; ETR103; G0S30; Krox-24; NGFI-A; TIS-8; TIS8; ZIF-268; zif268; ZNF225. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002144 EGR1; HGNC: EGR1. XX CL C0001; CH; XX SF 3 zinc finger motifs [1]; SF S/G, S/P [1]; SF the existence of a repressor domain within the C-terminal part of the protein has been suggested [5]; XX CP T-cells; troglitazone (TGZ) treated HCT-116 cells [14]; HUVEC [16]; PMA treated C2BBe1 cells [15]; UV, PMA or serum stimulated glioblastoma cell lines: U251, T98G, U-373MG and U-87MG (cells in quiescent stage) [11]; IL-1 alpha treated ECV304 cells [8]; bFGF stimulated Hep3B cells [7]; TPA treated K-562 cells [10]. XX FF activator; FF transiently expressed after mitogenic stimulation [1]; FF constitutively expressed after infection with HTLV-I or HTLV-II [1]; FF may be induced by PMA [2]; FF participates in down-regulation of GATA-1 and in the up-regulation of the megakaryocyte-specific gene CD41a [2]; FF immediate early gene in T-cell activation, mRNA is induced 30 min after stimulation [3]; FF can regulate transcription synergistically with NF-ATc [5] [4]; FF in several cases, binding sites for Egr-1 coincide with those for Sp1, for example in IL-2 promoter [3]; FF Egr-1 is important for the regulation of ELK-1 transcription in differentiating monocytes [6]; XX IN T08487 AR-isoform1; human, Homo sapiens. IN T00040 AR; human, Homo sapiens. IN T14513 beta-catenin; Mammalia. IN T00433 ITF-2; human, Homo sapiens. IN T16141 LEF-1; human, Homo sapiens. IN T05127 Mam-1; human, Homo sapiens. IN T11025 NFATc1; Mammalia. IN T11024 NFATc2; Mammalia. IN T00759 Sp1; human, Homo sapiens. IN T01560 SREBP-2; human, Homo sapiens. IN T22876 YAP; human, Homo sapiens. XX MX M00243 V$EGR1_01. MX M01972 V$EGR1_02. MX M03896 V$EGR1_07. MX M04797 V$EGR1_09. MX M04832 V$EGR1_10. MX M04869 V$EGR1_11. MX M04892 V$EGR1_12. MX M04918 V$EGR1_13. MX M04950 V$EGR1_15. MX M07208 V$EGR1_16. MX M07354 V$EGR1_Q3. MX M01873 V$EGR1_Q6. MX M08878 V$EGR_Q3. MX M00807 V$EGR_Q6. MX M00982 V$KROX_Q6. XX BS R20984. BS R17111. BS R23632. BS R24245. BS R24870. BS R24948. BS R25085. BS R37367. BS R19606. BS R20852. BS R20856. BS R21725. BS R29591. BS R61120. BS R66946. BS R28564. BS R37704. BS R64961. BS R26893. BS R41939. BS R24190. BS R69080. BS R69081. BS R24730. BS R24733. BS R22669. BS R39401. BS R08182. BS R25006. BS R34174. BS R67242. BS R20418. BS R58660. BS R33405. BS R33406. BS R33407. BS R36015. BS R70118. BS R16963. BS R32853. BS R60012. BS R32429. BS R24898. BS R32150. BS R32154. BS R24693. BS R24695. BS R24238. BS R24501. BS R24913. BS R14539. BS R31815. BS R23903. BS R30528. BS R31121. BS R32871. BS R32874. BS R31346. BS R26626. BS R31202. BS R33974. BS R33975. BS R23889. BS R28594. BS R28595. BS R28596. BS R68887. BS R32016. BS R24139. BS R24140. BS R04907. BS R69083. BS R69085. BS R69086. BS R34429. BS R57073. BS R59933. BS R25112. BS R56089. BS R15703. BS R32796. BS R58732. BS R69113. BS R69114. BS R30147. BS R30152. BS R24883. BS R24887. BS R24889. BS R22372. BS R24762. BS R24219. BS R62542. BS R57070. BS R58537. BS R71342. BS R24608. BS R31842. BS R21167. BS R69701. BS R24846. BS R31103. BS R17109. BS R68693. BS R68796. BS R68799. BS R68802. BS R62544. BS R24612. BS R24638. BS R24456. BS R24458. BS R71616. BS R61551. BS R21790. BS R30577. BS R32080. BS R66015. BS R66026. BS R31057. BS R31061. BS R31064. BS R58333. BS R58335. BS R58337. BS R58340. BS R58343. BS R65307. BS R62988. BS R14693. BS R14703. BS R14704. BS R14632. BS R71213. BS R31074. BS R60607. BS R25224. BS R01615. BS R25639. BS R65523. BS R34258. XX DR TRANSPATH: MO000017914. DR TRANSCOMPEL: C00356. DR TRANSCOMPEL: C00384. DR UniProtKB: P18146; EGR1_HUMAN. XX RN [1]; RE0002677. RX PUBMED: 2110381. RA Wright J. J., Gunter K. C., Mitsuya H., Irving St. G., Kelly K., Siebenlist U. RT Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells RL Science 248:588-591 (1990). RN [2]; RE0006699. RX PUBMED: 7983016. RA Cheng T., Wang Y., Dai W. RT Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells RL J. Biol. Chem. 269:30848-30853 (1994). RN [3]; RE0011295. RX PUBMED: 7673240. RA Skerka C., Decker E. L., Zipfel P. F. RT A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1 RL J. Biol. Chem. 270:22500-22506 (1995). RN [4]; RE0017818. RX PUBMED: 10508276. RA Li-Weber M., Laur O., Krammer P. H. RT Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation. RL Eur. J. Immunol. 29:3017-3027 (1999). RN [5]; RE0022849. RX PUBMED: 9756940. RA Decker E. L., Skerka C., Zipfel P. F. RT The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells. RL J. Biol. Chem. 273:26923-26930 (1998). RN [6]; RE0024298. RX PUBMED: 9880555. RA Lehmann U., Brocke P., Dittmer J., Nordheim A. RT Characterization of the human elk-1 promoter. Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes. RL J. Biol. Chem. 274:1736-1744 (1999). RN [7]; RE0027009. RX PUBMED: 9178905. RA Wang D., Mayo M. W., Baldwin A. S. Jr. RT Basic fibroblast growth factor transcriptional autoregulation requires EGR-1. RL Oncogene 14:2291-9 (1997). RN [8]; RE0027084. RX PUBMED: 10202038. RA Fitzgerald K. A., O'Neill L. A. RT Characterization of CD44 induction by IL-1: a critical role for Egr-1. RL J. Immunol. 162:4920-7 (1999). RN [9]; RE0030092. RX PUBMED: 12560487. RA Decker E. L., Nehmann N., Kampen E., Eibel H., Zipfel P. F., Skerka C. RT Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. RL Nucleic Acids Res. 31:911-21 (2003). RN [10]; RE0034687. RX PUBMED: 10392899. RA McCoy C., McGee S. B., Cornwell M. M. RT The Wilms' tumor suppressor, WT1, inhibits 12-O-tetradecanoylphorbol-13-acetate activation of the multidrug resistance-1 promoter. RL Cell Growth Differ. 10:377-86 (1999). RN [11]; RE0045368. RX PUBMED: 10783396. RA Liu C., Yao J., Mercola D., Adamson E. RT The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251 RL J. Biol. Chem. 275:20315-23 (2000). RN [12]; RE0048464. RX PUBMED: 16702209. RA Chen S. J., Ning H., Ishida W., Sodin-Semrl S., Takagawa S., Mori Y., Varga J. RT The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression. RL J. Biol. Chem. 281:21183-21197 (2006). RN [13]; RE0049003. RX PUBMED: 12890669. RA Yang S. Z., Abdulkadir S. A. RT Early growth response gene 1 modulates androgen receptor signaling in prostate carcinoma cells. RL J. Biol. Chem. 278:39906-39911 (2003). RN [14]; RE0052319. RX PUBMED: 12475986. RA Baek S. J., Wilson L. C., Hsi L. C., Eling T. E. RT Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. RL J. Biol. Chem. 278:5845-5853 (2003). RN [15]; RE0053242. RX PUBMED: 15976391. RA Malakooti J., Sandoval R., Memark V. C., Dudeja P. K., Ramaswamy K. RT Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate. RL Am. J. Physiol. Gastrointest. Liver Physiol. 289:G653-63 (2005). RN [16]; RE0053454. RX PUBMED: 17675290. RA Wang J., Mahmud S. A., Bitterman P. B., Huo Y., Slungaard A. RT Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. RL J. Biol. Chem. 282:28408-28418 (2007). RN [17]; RE0055381. RX PUBMED: 15003938. RA Hjoberg J., Le L., Imrich A., Subramaniam V., Mathew S. I., Vallone J., Haley K. J., Green F. H., Shore S. A., Silverman E. S. RT Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle. RL Am. J. Physiol. Lung Cell. Mol. Physiol. 286:L817-25 (2004). RN [18]; RE0066799. RX PUBMED: 20448047. RA Patel N., Kalra V. K. RT Placenta growth factor (PlGF)-induced early growth response 1 (Egr-1) regulates hypoxia inducible factor-1{alpha} (HIF-1{alpha}) in endothelial cells. RL J. Biol. Chem. 285:20570-20579 (2010). RN [19]; RE0067064. RX PUBMED: 20515787. RA Zhang J., Valianou M., Cheng J. D. RT Identification and characterization of the promoter of fibroblast activation protein. RL Front Biosci (Elite Ed). 2:1154-1163 (2010). XX //