AC T16010
XX
ID T16010
XX
DT 10.03.2005 (created); nvo.
DT 11.11.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA TCF-4
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SY T-cell factor 4; TCF-4; Tcf4; TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T15601 AR; Mammalia.
IN T02872 beta-catenin; human, Homo sapiens.
IN T14513 beta-catenin; Mammalia.
IN T10784 CtBP1; Mammalia.
IN T02944 Daxx; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T16015 ER-beta; Mammalia.
IN T16341 hbp1; rat, Rattus norvegicus.
IN T08297 Kaiso; human, Homo sapiens.
IN T33787 Kaiso; Mammalia.
IN T23091 p300; Mammalia.
IN T10138 SF-1; Mammalia.
XX
MX M01705 V$TCF4_01.
MX M00671 V$TCF4_Q5.
MX M02033 V$TCF4_Q5_01.
MX M04633 V$TCF4_Q5_02.
XX
BS R08576.
BS R36602.
BS R55805.
BS R57143.
BS R57144.
BS R58482.
BS R27837.
BS R27839.
BS R30795.
BS R32765.
BS R66383.
BS R58459.
BS R58471.
BS R62757.
BS R41758.
BS R62759.
XX
DR TRANSPATH: MO000047194.
XX
RN [1]; RE0014098.
RX PUBMED: 10555149.
RA He T. C., Chan T. A., Vogelstein B., Kinzler K. W.
RT PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
RL Cell 99:335-345 (1999).
RN [2]; RE0014134.
RX PUBMED: 10027409.
RA Wielenga V.J., Smits R., Korinek V., Smit L., Kielman M., Fodde R., Clevers H., Pals S. T.
RT Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
RL Am. J. Pathol. 154:515-523 (1999).
RN [3]; RE0022276.
RX PUBMED: 11931652.
RA Marchenko G. N., Marchenko N. D., Leng J., Strongin A. Y.
RT Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin.
RL Biochem. J. 363:253-262 (2002).
RN [4]; RE0023544.
RX PUBMED: 11522780.
RA El-Tanani M., Fernig D. G., Barraclough R., Green C., Rudland P.
RT Differential modulation of transcriptional activity of estrogen receptors by direct protein-protein interactions with the T cell factor family of transcription factors.
RL J. Biol. Chem. 276:41675-41682 (2001).
RN [5]; RE0023725.
RX PUBMED: 12556497.
RA Ishitani T., Ninomiya-Tsuji J., Matsumoto K.
RT Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.
RL Mol. Cell. Biol. 23:1379-1389 (2003).
RN [6]; RE0023735.
RX PUBMED: 12711682.
RA Valenta T., Lukas J., Korinek V.
RT HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells.
RL Nucleic Acids Res. 31:2369-2380 (2003).
RN [7]; RE0024494.
RX PUBMED: 11711551.
RA Miravet S., Piedra J., Miro F., Itarte E., Garcia de Herreros A., Dunach M.
RT The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin.
RL J. Biol. Chem. 277:1884-1891 (2002).
RN [8]; RE0030537.
RX PUBMED: 12799378.
RA Amir A. L., Barua M., McKnight N. C., Cheng S., Yuan X., Balk S. P.
RT A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4.
RL J. Biol. Chem. 278:30828-34 (2003).
RN [9]; RE0031434.
RX PUBMED: 14592850.
RA Wang X., Adhikari N., Li Q., Guan Z., Hall J. L.
RT The role of [beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells.
RL Arterioscler. Thromb. Vasc. Biol. 24:85-90 (2004).
RN [10]; RE0031438.
RX PUBMED: 14706452.
RA Li Q., Dashwood W. M., Zhong X., Al-Fageeh M., Dashwood R. H.
RT Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.
RL Genomics 83:231-42 (2004).
RN [11]; RE0034213.
RX PUBMED: 15292219.
RA Lei S., Dubeykovskiy A., Chakladar A., Wojtukiewicz L., Wang T. C.
RT The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.
RL J. Biol. Chem. 279:42492-502 (2004).
RN [12]; RE0037525.
RX PUBMED: 12384519.
RA Takahashi M., Fujita M., Furukawa Y., Hamamoto R., Shimokawa T., Miwa N., Ogawa M., Nakamura Y.
RT Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis
RL Cancer Res. 62:5651-6 (2002).
RN [13]; RE0037576.
RX PUBMED: 15077166.
RA Tong X., O'kelly J., Xie D., Mori A., Lemp N., McKenna R., Miller C. W., Koeffler H. P.
RT Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway
RL Oncogene 23:4847-55 (2004).
RN [14]; RE0037579.
RX PUBMED: 15116100.
RA Pradeep A., Sharma C., Sathyanarayana P., Albanese C., Fleming J. V., Wang T. C., Wolfe M. M., Baker K. M., Pestell R. G., Rana B.
RT Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells
RL Oncogene 23:3689-99 (2004).
RN [15]; RE0037580.
RX PUBMED: 11504726.
RA Palacino J. J., Murphy M. P., Murayama O., Iwasaki K., Fujiwara M., Takashima A., Golde T. E., Wolozin B.
RT Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion
RL J. Biol. Chem. 276:38563-9 (2001).
RN [16]; RE0037605.
RX PUBMED: 12651860.
RA Ghiselli G., Coffee N., Munnery C. E., Koratkar R., Siracusa L. D.
RT The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway
RL J. Biol. Chem. 278:20259-67 (2003).
RN [17]; RE0037608.
RX PUBMED: 12727872.
RA Yamamoto H., Ihara M., Matsuura Y., Kikuchi A.
RT Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
RL EMBO J. 22:2047-59 (2003).
RN [18]; RE0037609.
RX PUBMED: 11454716.
RA El-Tanani M., Barraclough R., Wilkinson M. C., Rudland P. S.
RT Metastasis-inducing dna regulates the expression of the osteopontin gene by binding the transcription factor Tcf-4
RL Cancer Res. 61:5619-29 (2001).
RN [19]; RE0037624.
RX PUBMED: 11861424.
RA Wang X., Xiao Y., Mou Y., Zhao Y., Blankesteijn W. M., Hall J. L.
RT A role for the beta-catenin/T-cell factor signaling cascade in vascular remodeling
RL Circ. Res. 90:340-7 (2002).
RN [20]; RE0037675.
RX PUBMED: 11939410.
RA Miwa N., Furuse M., Tsukita S., Niikawa N., Nakamura Y., Furukawa Y.
RT Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers
RL Oncol. Res. 12:469-76 (2001).
RN [21]; RE0038209.
RX PUBMED: 14559787.
RA Shimokawa T., Furukawa Y., Sakai M., Li M., Miwa N., Lin Y. M., Nakamura Y.
RT Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex
RL Cancer Res. 63:6116-20 (2003).
RN [22]; RE0040278.
RX PUBMED: 12063257.
RA Liu T., Lee Y. N., Malbon C. C., Wang H. Y.
RT Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid
RL J. Biol. Chem. 277:30887-91 (2002).
RN [23]; RE0040430.
RX PUBMED: 12048202.
RA Rodova M., Islam M. R., Maser R. L., Calvet J. P.
RT The polycystic kidney disease-1 promoter is a target of the beta-catenin/T-cell factor pathway
RL J. Biol. Chem. 277:29577-83 (2002).
RN [24]; RE0045344.
RX PUBMED: 15374939.
RA Shimura T., Takenaka Y., Tsutsumi S., Hogan V., Kikuchi A., Raz A.
RT Galectin-3, a novel binding partner of beta-catenin
RL Cancer Res. 64:6363-7 (2004).
RN [25]; RE0048262.
RX PUBMED: 16210377.
RA Singh R., Artaza J. N., Taylor W. E., Braga M., Yuan X., Gonzalez-Cadavid N. F., Bhasin S.
RT Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors.
RL Endocrinology 147:141-154 (2006).
RN [26]; RE0050491.
RX PUBMED: 16569639.
RA Tzeng S. L., Cheng Y. W., Li C. H., Lin Y. S., Hsu H. C., Kang J. J.
RT Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells.
RL J. Biol. Chem. 281:15405-15411 (2006).
RN [27]; RE0062827.
RX PUBMED: 19443654.
RA Hong C. F., Chou Y. T., Lin Y. S., Wu C. W.
RT MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.
RL J. Biol. Chem. 284:19613-19622 (2009).
RN [28]; RE0066628.
RX PUBMED: 11500377.
RA Sampson E. M., Haque Z. K., Ku M. C., Tevosian S. G., Albanese C., Pestell R. G., Paulson K. E., Yee A. S.
RT Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
RL EMBO J. 20:4500-4511 (2001).
XX
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