AC T16596
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ID T16596
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DT 10.03.2005 (created); nvo.
DT 30.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA foxo4
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T14513 beta-catenin; Mammalia.
IN T15118 CBP; Mammalia.
IN T09637 ER-alpha; Mammalia.
IN T14713 FOXK1; mouse, Mus musculus.
IN T21754 FoxK1; Mammalia.
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MX M00472 V$FOXO4_01.
MX M00476 V$FOXO4_02.
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BS R66301.
BS R67621.
BS R38380.
BS R69836.
BS R67626.
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DR TRANSPATH: MO000047898.
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RN [1]; RE0021218.
RX PUBMED: 11777915.
RA Tang T. T.-L., Dowbenko D., Jackson A., Toney L., Lewin D. A., Dent A. L., Lasky L. A.
RT The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor
RL J. Biol. Chem. 277:14255-14265 (2002).
RN [2]; RE0025194.
RX PUBMED: 10518537.
RA Takaishi H., Konishi H., Matsuzaki H., Ono Y., Shirai Y., Saito N., Kitamura T., Ogawa W., Kasuga M., Kikkawa U., Nishizuka Y.
RT Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.
RL Proc. Natl. Acad. Sci. USA 96:11836-11841 (1999).
RN [3]; RE0025218.
RX PUBMED: 11313479.
RA Brownawell A. M., Kops G. J., Macara I. G., Burgering B. M.
RT Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
RL Mol. Cell. Biol. 21:3534-3546 (2001).
RN [4]; RE0033103.
RX PUBMED: 12761217.
RA Tang T. T., Lasky L. A.
RT The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.
RL J. Biol. Chem. 278:30125-35 (2003).
RN [5]; RE0033107.
RX PUBMED: 15126506.
RA van der Horst A., Tertoolen L. G., de Vries-Smits L. M., Frye R. A., Medema R. H., Burgering B. M.
RT FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).
RL J. Biol. Chem. 279:28873-9 (2004).
RN [6]; RE0054983.
RX PUBMED: 18794148.
RA Brenkman A. B., de Keizer P. L., van den Broek N. J., van der Groep P., van Diest P. J., van der Horst A., Smits A. M., Burgering B. M.
RT The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors.
RL Cancer Res. 68:7597-7605 (2008).
RN [7]; RE0056060.
RX PUBMED: 17038621.
RA Huang H., Regan K. M., Lou Z., Chen J., Tindall D. J.
RT CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
RL Science 314:294-297 (2006).
RN [8]; RE0070735.
RX PUBMED: 20110348.
RA Singh A., Ye M., Bucur O., Zhu S., Tanya Santos M., Rabinovitz I., Wei W., Gao D., Hahn W. C., Khosravi-Far R.
RT Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.
RL Mol. Biol. Cell 21:1140-1152 (2010).
RN [9]; RE0071936.
RX PUBMED: 15905404.
RA Essers M. A., de Vries-Smits L. M., Barker N., Polderman P. E., Burgering B. M., Korswagen H. C.
RT Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
RL Science 308:1181-1184 (2005).
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