AC T00882
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ID T00882
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DT 28.01.1993 (created); hse.
DT 13.06.2014 (updated); vad.
CO Copyright (C), QIAGEN.
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FA VDR
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SY 1,25-dihydroxyvitamin D3 receptor; NR1I1; VDR; vitamin D receptor.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014467 Vdr.
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CL C0002; CC (rec); 2.1.2.4.1.
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SF phosphorylation;
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CP (embryo:) not detectable in intestine at embryonic E14, but high levels in intestine at E21 [4]; (adult:) high levels in kidney and intestine [4] [5]; expressed in parathyroid gland [6]; probably weakly expressed in heart [4] [4] [5] [6].
CN not detectable in liver and spleen [4].
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FF native ligand is 1,25-dihydroxyvitamin D3 [4];
FF requires an additional nuclear accessory protein, different from RXR-alpha or RXR-beta for DNA-binding;
FF seem be involved in 1,25-dihydroxyvitamin D3 mediation suppression of transcription of parathyroid hormone (PTH) gene G002906 [6];
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IN T02441 AML3; rat, Rattus norvegicus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01349 RXR-beta; rat, Rattus norvegicus.
IN T04431 Smad3; rat, Rattus norvegicus.
IN T04632 SRC-1; human, Homo sapiens.
IN T21552 SRC-1; Mammalia.
IN T08497 TIF2; human, Homo sapiens.
IN T01355 TRAP; human, Homo sapiens.
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MX M00966 V$DR3_Q4.
MX M00444 V$VDR_Q3.
MX M00961 V$VDR_Q6.
MX M03569 V$VDR_Q6_01.
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BS R10017.
BS R62361.
BS R73856.
BS R02261.
BS R03524.
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DR TRANSPATH: MO000021496.
DR UniProtKB: P13053;
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RN [1]; RE0000117.
RX PUBMED: 2159384.
RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado J., Pike J. W., Evans R. M.
RT Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene
RL Cell 61:497-504 (1990).
RN [2]; RE0002373.
RX PUBMED: 2835767.
RA Baker A. R., McDonnell D. P., Hughes M., Crisp T. M., Mangelsdorf D. J., Haussler M. R., Pike J. W., Shine J., O'Malley B. W.
RT Cloning and expression of full-length cDNA encoding human vitamin D receptor
RL Proc. Natl. Acad. Sci. USA 85:3294-3298 (1988).
RN [3]; RE0002565.
RX PUBMED: 1332041.
RA Ross T. K., Prahl J. M., Herzberg I. M., DeLuca H. F.
RT Baculovirus-mediated expression of retinoic acid receptor type gamma in cultured insect cells reveals a difference in specific DNA-binding behavior with the 1,25-dihydroxyvitamin D3 receptor
RL Proc. Natl. Acad. Sci. USA 89:10282-10286 (1992).
RN [4]; RE0016357.
RX PUBMED: 2849110.
RA Burmester J. K., Wiese R. J., Maeda N., DeLuca H. F.
RT Structure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor
RL Proc. Natl. Acad. Sci. USA 85:9499-9502 (1988).
RN [5]; RE0016376.
RX PUBMED: 7972109.
RA Elaroussi M. A., Prahl J. M., DeLuca H. F.
RT The avian vitamin D receptors: primary structures and their origins
RL Proc. Natl. Acad. Sci. USA 91:11596-11600 (1994).
RN [6]; RE0017141.
RX PUBMED: 2174913.
RA Naveh-Many T., Marx R., Keshet E., Pike J. W., Silver J.
RT Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo
RL J. Clin. Invest. 86:1968-1975 (1990).
RN [7]; RE0035930.
RX PUBMED: 15456860.
RA Paredes R., Arriagada G., Cruzat F., Villagra A., Olate J., Zaidi K., van Wijnen A., Lian J. B., Stein G. S., Stein J. L., Montecino M.
RT Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells.
RL Mol. Cell. Biol. 24:8847-8861 (2004).
RN [8]; RE0047490.
RX PUBMED: 9891040.
RA Takeyama K., Masuhiro Y., Fuse H., Endoh H., Murayama A., Kitanaka S., Suzawa M., Yanagisawa J., Kato S.
RT Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog.
RL Mol. Cell. Biol. 19:1049-1055 (1999).
RN [9]; RE0048867.
RX PUBMED: 16195230.
RA Shen Q., Christakos S.
RT The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin.
RL J. Biol. Chem. 280:40589-40598 (2005).
RN [10]; RE0051749.
RX PUBMED: 1656468.
RA Hsieh J. C., Jurutka P. W., Galligan M. A., Terpening C. M., Haussler C. A., Samuels D. S., Shimizu Y., Shimizu N., Haussler M. R.
RT Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.
RL Proc. Natl. Acad. Sci. USA 88:9315-9319 (1991).
RN [11]; RE0053353.
RX PUBMED: 11592788.
RA Aschenbrenner J. K., Sollinger H. W., Becker B. N., Hullett D. A.
RT 1,25-(OH(2))D(3) alters the transforming growth factor beta signaling pathway in renal tissue.
RL J. Surg. Res. 100:171-175 (2001).
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