AC T08497
XX
ID T08497
XX
DT 30.01.2006 (created); rad.
DT 15.05.2014 (updated); ili.
CO Copyright (C), QIAGEN.
XX
FA TIF2
XX
SY glucocorticoid receptor interacting protein 1; GRIP1; transcriptional intermediary factor 2.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004703 NCOA2; HGNC: NCOA2.
XX
CL C0010; bHLH.
XX
SZ 1464 AA; 159.1 kDa (cDNA) (calc.).
XX
SQ MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
SQ DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
SQ EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
SQ VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
SQ EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
SQ RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
SQ TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
SQ SNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPG
SQ QPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQAL
SQ SEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA
SQ ESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASS
SQ LSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESS
SQ STAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK
SQ LIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAII
SQ NDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG
SQ PFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSA
SQ VRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGG
SQ PQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALL
SQ DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQ
SQ AQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQ
SQ QNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQ
SQ RTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATT
SQ PQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQAN
SQ TSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGG
SQ NLFPNQLPGMDMIKQEGDTTRKYC
XX
SC Swiss-Prot#Q15596
XX
FT 16 84 
PS50888; HLH.
FT 32 89 
SM00353; finulus.
FT 56 1430 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 114 181 
SM00091; pas_2.
FT 115 368 
bHLH/PAS domain (basic helix-loop-helix/Per-Arnt-Sim domain) [11].
FT 119 183 
PS50112; PAS.
FT 624 869 
NID (nuclear receptor interacting domain), interaction with AF-2 domain [10].
FT 641 645 
NR-box motif (LXXLL) [10].
FT 690 694 
NR-box motif (LXXLL) [10].
FT 745 749 
NR-box motif (LXXLL) [10].
FT 1010 1131 activation domain 1 (AD1), CBP-interacting domain [10].
FT 1281 1338 PF07469; Domain of unknown function (DUF1518).
FT 1288 1464 activation domain 2 (AD2) [10].
XX
IN T05362 CBP; rat, Rattus norvegicus.
IN T08450 DAX1; mouse, Mus musculus.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T08515 ER-beta; human, Homo sapiens.
IN T05682 ERR1-isoform1; human, Homo sapiens.
IN T04498 FXR-isoform4; human, Homo sapiens.
IN T10946 LXR-beta; rat, Rattus norvegicus.
IN T11333 TBX19; human, Homo sapiens.
IN T10505 TTF-1; Mammalia.
IN T00882 VDR; rat, Rattus norvegicus.
XX
DR TRANSPATH: MO000059018.
DR EMBL: X97674;
DR UniProtKB: Q15596;
XX
RN [1]; RE0018271.
RX PUBMED: 10617585.
RA Naltner A., Ghaffari M., Whitsett J. A., Yan C.
RT Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.
RL J. Biol. Chem. 275:56-62 (2000).
RN [2]; RE0023352.
RX PUBMED: 12529392.
RA Otte K., Kranz H., Kober I., Thompson P., Hoefer M., Haubold B., Remmel B., Voss H., Kaiser C., Albers M., Cheruvallath Z., Jackson D., Casari G., Koegl M., Paabo S., Mous J., Kremoser C., Deuschle U.
RT Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.
RL Mol. Cell. Biol. 23:864-872 (2003).
RN [3]; RE0041230.
RX PUBMED: 10747867.
RA Kobayashi Y., Kitamoto T., Masuhiro Y., Watanabe M., Kase T., Metzger D., Yanagisawa J., Kato S.
RT p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains
RL J. Biol. Chem. 275:15645-51 (2000).
RN [4]; RE0047490.
RX PUBMED: 9891040.
RA Takeyama K., Masuhiro Y., Fuse H., Endoh H., Murayama A., Kitanaka S., Suzawa M., Yanagisawa J., Kato S.
RT Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog.
RL Mol. Cell. Biol. 19:1049-1055 (1999).
RN [5]; RE0050921.
RX PUBMED: 10936612.
RA Song C., Hiipakka R. A., Liao S.
RT Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs.
RL Steroids 65:423-427 (2000).
RN [6]; RE0051059.
RX PUBMED: 11089551.
RA Song C., Liao S.
RT Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha.
RL Endocrinology 141:4180-4184 (2000).
RN [7]; RE0053034.
RX PUBMED: 16059639.
RA Liu Y., Shen Q., Malloy P. J., Soliman E., Peng X., Kim S., Pike J. W., Feldman D., Christakos S.
RT Enhanced coactivator binding and transcriptional activation of mutant vitamin D receptors from patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets by phosphorylation and vitamin D analogs.
RL J. Bone Miner. Res. 20:1680-1691 (2005).
RN [8]; RE0053654.
RX PUBMED: 18441008.
RA Greschik H., Althage M., Flaig R., Sato Y., Peluso-Iltis C., Chavant V., Choulier L., Cronet P., Rochel N., Schule R., Stromstedt P. E., Moras D.
RT Communication between the ERR alpha homodimer interface and the PGC-1alpha binding surface vie the helix 8-9 loop.
RL J. Biol. Chem. 283:20220-20230 (2008).
RN [9]; RE0068206.
RX PUBMED: 12970370.
RA Maira M., Couture C., Le Martelot G., Pulichino A. M., Bilodeau S., Drouin J.
RT The T-box factor Tpit recruits SRC/p160 co-activators and mediates hormone action.
RL J. Biol. Chem. 278:46523-46532 (2003).
RN [10]; RE0006908.
RX PUBMED: 9430642.
RA Voegel J. J., Heine M. J., Tini M., Vivat V., Chambon P., Gronemeyer H.
RT The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
RL EMBO J. 17:507-519 (1998).
RN [11]; RE0017628.
RX PUBMED: 10692587.
RA Jimenez-Lara A. M., Heine M. J., Gronemeyer H.
RT Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family
RL FEBS Lett. 468:203-210 (2000).
XX
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