AC T05682
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ID T05682
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DT 14.10.2003 (created); ech.
DT 12.10.2011 (updated); mka.
CO Copyright (C), QIAGEN.
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FA ERR1-isoform1
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SY ERR1; ERRa; ERRalpha; ESRL1; ESRRA; estrogen-related receptor alpha; NR3B1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006038 ESRRA; HGNC: ESRRA.
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CL C0002; CC (rec); 2.1.1.2.3.1.
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SZ 423 AA; 45.6 kDa (calc.), 53 kDa [1]
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SQ SSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGP
SQ GEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNEC
SQ EITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPL
SQ AVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTIS
SQ WAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAG
SQ LGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDEPRLWSSCEKLLHEALL
SQ EYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA
SQ MMD
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SC Swiss-Prot#P11474-1
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FT 75 146 
SM00399; c4gold.
FT 75 150 
PS51030; NUCLEAR_REC_DBD_2.
FT 76 151 
PF00105; Zinc finger, C4 type (two domains).
FT 229 392 
SM00430; holi.
FT 232 417 
PF00104; Ligand-binding domain of nuclear hormon.
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SF for another splice-variant see T02765;
SF recognizes ERE-half-sites as a monomer [1];
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FF repressor [1];
FF repressor of ERE-dependent ER-stimulated transcription, but activator of ERE-dependent transcription in ER-negative cells [2];
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IN T05295 PGC-1-isoform1; human, Homo sapiens.
IN T08497 TIF2; human, Homo sapiens.
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MX M00511 V$ERR1_Q2.
MX M02093 V$ERR1_Q2_01.
MX M01841 V$ERR1_Q3.
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BS R14198.
BS R36827.
BS R25021.
BS R25024.
BS R14195.
BS R14196.
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DR TRANSPATH: MO000046239.
DR EMBL: X51416;
DR UniProtKB: P11474-1;
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RN [1]; RE0023313.
RX PUBMED: 9058380.
RA Johnston S. D., Liu X., Zuo F., Eisenbraun T. L., Wiley S. R., Kraus R. J., Mertz J. E.
RT Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements.
RL Mol. Endocrinol. 11:342-352 (1997).
RN [2]; RE0023314.
RX PUBMED: 11986328.
RA Kraus R. J., Ariazi E. A., Farrell M. L., Mertz J. E.
RT Estrogen-related receptor alpha 1 actively antagonizes estrogen receptor-regulated transcription in MCF-7 mammary cells.
RL J. Biol. Chem. 277:24826-24834 (2002).
RN [3]; RE0053654.
RX PUBMED: 18441008.
RA Greschik H., Althage M., Flaig R., Sato Y., Peluso-Iltis C., Chavant V., Choulier L., Cronet P., Rochel N., Schule R., Stromstedt P. E., Moras D.
RT Communication between the ERR alpha homodimer interface and the PGC-1alpha binding surface vie the helix 8-9 loop.
RL J. Biol. Chem. 283:20220-20230 (2008).
RN [4]; RE0054701.
RX PUBMED: 17259347.
RA Ariazi E. A., Kraus R. J., Farrell M. L., Jordan V. C., Mertz J. E.
RT Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway.
RL Mol. Cancer Res. 5:71-85 (2007).
RN [5]; RE0069929.
RX PUBMED: 18063693.
RA Tremblay A. M., Wilson B. J., Yang X. J., Giguere V.
RT Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.
RL Mol. Endocrinol. 22:570-584 (2008).
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