AC T10946
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ID T10946
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DT 20.10.2007 (created); bch.
DT 20.11.2007 (updated); bch.
CO Copyright (C), QIAGEN.
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FA LXR-beta
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SY LXR B; LXR-B; LXRB; NER; NR1H2; nuclear orphan receptor LXR-beta; orphan nuclear receptor OR-1; oxysterol receptor LXR-beta; ubiquitously expressed nuclear receptor; UR.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002741 Nr1h2.
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CL C0002; CC (rec).
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SZ 446 AA; 49.8 kDa (cDNA) (calc.).
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SQ MSSPTSSLDTPLPGNGSPQPSTSSTSPTIKEEVQETDPPPGSEGSSSAYIVVILEPEDEP
SQ ERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSG
SQ TCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKKIQKQQQQQPPPPTEPASGSS
SQ ARPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLG
SQ ADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLE
SQ TARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIA
SQ INIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVH
SQ SEQVFALRLQDKKLPPLLSEIWDVHE
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SC translated from EMBL #U20389
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FT 1 77 
aminoterminal domain with PEST sequence [2].
FT 75 148 
SM00399; c4gold.
FT 75 152 
PS51030; NUCLEAR_REC_DBD_2.
FT 76 153 
PF00105; Zinc finger, C4 type (two domains).
FT 146 446 
putative ligand-binding domain [2].
FT 258 417 
SM00430; holi.
FT 261 441 
PF00104; Ligand-binding domain of nuclear hormon.
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IN T08497 TIF2; human, Homo sapiens.
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MX M00965 V$DR4_Q2.
MX M00647 V$LXR_Q3.
MX M03795 V$LXR_Q6.
MX M07280 V$NR1NR2_Q3.
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BS R09956.
BS R09966.
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DR TRANSPATH: MO000115766.
DR EMBL: U14533;
DR EMBL: U20389;
DR UniProtKB: Q62755;
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RN [1]; RE0001904.
RX PUBMED: 2922054.
RA Mader S., Kumar V., de Verneuil H., Chambon P.
RT Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element
RL Nature 338:271-275 (1989).
RN [2]; RE0010769.
RX PUBMED: 7892230.
RA Teboul M., Enmark E., Li Q., Wikstrom A. C., Pelto-Huikko M., Gustafsson J.-A.
RT OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor
RL Proc. Natl. Acad. Sci. USA 92:2096-2100 (1995).
RN [3]; RE0016034.
RX PUBMED: 7971966.
RA Song C., Kokontis J. M., Hiipakka R. A., Liao S.
RT Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors
RL Proc. Natl. Acad. Sci. USA 91:10809-10813 (1994).
RN [4]; RE0050921.
RX PUBMED: 10936612.
RA Song C., Hiipakka R. A., Liao S.
RT Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs.
RL Steroids 65:423-427 (2000).
RN [5]; RE0051059.
RX PUBMED: 11089551.
RA Song C., Liao S.
RT Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha.
RL Endocrinology 141:4180-4184 (2000).
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