AC T02002
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ID T02002
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DT 13.12.1996 (created); ewi.
DT 04.09.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA Cdx-2
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SY caudal homolog homeobox protein 2; caudal type homeo box 2; Cdx-2; CDX2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001230 Cdx2.
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HO Cad (Drosophila).
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CL C0006; homeo; 3.1.1.9.2.
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SF dimeric DNA-binding [3];
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CP (embryo 8.5 days:) tail bud, caudal neural plate/tube and notochord, (embryo 12.5 d.) gut endoderm, caudal tip of neural tube, (embryo >15 d.) intestinal epithelial cells (duodenum, jejunum, ileum, cecum, colon), cell lines (STC-1, GLUTag) [6] [3].
CN brain, heart, kidney, liver, lung, muscle, pancreas, spleen, testis [3].
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FF activator of intestine-specific promoters [6] [3];
FF may be redox-regulated [3];
FF regulates both proliferation and differentiation in intestinal epithelial cells [5];
FF CBP is a coactivator interacting with the homeo domain of Cdx-2;
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IN T01318 CBP; mouse, Mus musculus.
IN T02002 Cdx-2; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
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MX M01449 V$CDX2_01.
MX M00729 V$CDX2_Q5.
MX M01659 V$CDX2_Q5_01.
MX M02087 V$CDX2_Q5_02.
MX M07416 V$CDX2_Q6.
MX M07378 V$CDX_Q4.
MX M00991 V$CDX_Q5.
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BS R26176.
BS R26171.
BS R26172.
BS R08886.
BS R36215.
BS R69533.
BS R69529.
BS R69531.
BS R69532.
BS R68252.
BS R68254.
BS R68255.
BS R68256.
BS R40460.
BS R69526.
BS R62837.
BS R62840.
BS R14710.
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DR TRANSPATH: MO000026083.
DR PATHODB: MT010485.
DR UniProtKB: P43241;
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RN [1]; RE0005015.
RX PUBMED: 1671571.
RA James R. J., Kazenwadel J.
RT Homeobox gene expression in the intetnal epithelium of adult mice
RL J. Biol. Chem. 266:3246-3251 (1991).
RN [2]; RE0005016.
RX PUBMED: 7910823.
RA James R. J., Erler T., Kazenwadel J.
RT Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestine epithelium
RL J. Biol. Chem. 269:15229-15237 (1994).
RN [3]; RE0005017.
RX PUBMED: 7935448.
RA Suh E., Chen L., Taylor J., Traber P. G.
RT A homeodomain protein related to caudal regulates intestine-specific gene transcription
RL Mol. Cell. Biol. 14:7340-7351 (1994).
RN [4]; RE0011831.
RX PUBMED: 8524295.
RA Jin T., Drucker D. J.
RT Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3
RL Mol. Cell. Biol. 16:19-28 (1996).
RN [5]; RE0014381.
RX PUBMED: 8552090.
RA Suh E., Traber P. G.
RT An intestine-specific homeobox gene regulates proliferation and differentiation
RL Mol. Cell. Biol. 16:619-625 (1996).
RN [6]; RE0014389.
RX PUBMED: 9171078.
RA Taylor J. K., Levy T., Suh E. R., Traber P. G.
RT Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific
RL Nucleic Acids Res. 25:2293-2300 (1997).
RN [7]; RE0014407.
RX PUBMED: 9428790.
RA Taylor J. K., Boll W., Levy T., Suh E., Siang S., Mantei N., Traber P. G.
RT Comparison of intestinal phospholipase A/lysophospholipase and sucrase-isomaltase genes suggest a common structure for enterocyte-specific promoters
RL DNA Cell Biol. 16:1419-1428 (1997).
RN [8]; RE0047972.
RX PUBMED: 10506141.
RA Hussain M. A., Habener J. F.
RT Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator.
RL J. Biol. Chem. 274:28950-28957 (1999).
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