TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02002 XX ID T02002 XX DT 13.12.1996 (created); ewi. DT 04.09.2015 (updated); jmh. CO Copyright (C), QIAGEN. XX FA Cdx-2 XX SY caudal homolog homeobox protein 2; caudal type homeo box 2; Cdx-2; CDX2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001230 Cdx2. XX HO Cad (Drosophila). XX CL C0006; homeo; XX SF dimeric DNA-binding [3]; XX CP (embryo 8.5 days:) tail bud, caudal neural plate/tube and notochord, (embryo 12.5 d.) gut endoderm, caudal tip of neural tube, (embryo >15 d.) intestinal epithelial cells (duodenum, jejunum, ileum, cecum, colon), cell lines (STC-1, GLUTag) [6] [3]. CN brain, heart, kidney, liver, lung, muscle, pancreas, spleen, testis [3]. XX FF activator of intestine-specific promoters [6] [3]; FF may be redox-regulated [3]; FF regulates both proliferation and differentiation in intestinal epithelial cells [5]; FF CBP is a coactivator interacting with the homeo domain of Cdx-2; XX IN T01318 CBP; mouse, Mus musculus. IN T02002 Cdx-2; mouse, Mus musculus. IN T10542 p300; mouse, Mus musculus. XX MX M01449 V$CDX2_01. MX M00729 V$CDX2_Q5. MX M01659 V$CDX2_Q5_01. MX M02087 V$CDX2_Q5_02. MX M07416 V$CDX2_Q6. MX M07378 V$CDX_Q4. MX M00991 V$CDX_Q5. XX BS R26176. BS R26171. BS R26172. BS R08886. BS R36215. BS R69533. BS R69529. BS R69531. BS R69532. BS R68252. BS R68254. BS R68255. BS R68256. BS R40460. BS R69526. BS R62837. BS R62840. BS R14710. XX DR TRANSPATH: MO000026083. DR PATHODB: MT010485. DR UniProtKB: P43241; XX RN [1]; RE0005015. RX PUBMED: 1671571. RA James R. J., Kazenwadel J. RT Homeobox gene expression in the intetnal epithelium of adult mice RL J. Biol. Chem. 266:3246-3251 (1991). RN [2]; RE0005016. RX PUBMED: 7910823. RA James R. J., Erler T., Kazenwadel J. RT Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestine epithelium RL J. Biol. Chem. 269:15229-15237 (1994). RN [3]; RE0005017. RX PUBMED: 7935448. RA Suh E., Chen L., Taylor J., Traber P. G. RT A homeodomain protein related to caudal regulates intestine-specific gene transcription RL Mol. Cell. Biol. 14:7340-7351 (1994). RN [4]; RE0011831. RX PUBMED: 8524295. RA Jin T., Drucker D. J. RT Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3 RL Mol. Cell. Biol. 16:19-28 (1996). RN [5]; RE0014381. RX PUBMED: 8552090. RA Suh E., Traber P. G. RT An intestine-specific homeobox gene regulates proliferation and differentiation RL Mol. Cell. Biol. 16:619-625 (1996). RN [6]; RE0014389. RX PUBMED: 9171078. RA Taylor J. K., Levy T., Suh E. R., Traber P. G. RT Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific RL Nucleic Acids Res. 25:2293-2300 (1997). RN [7]; RE0014407. RX PUBMED: 9428790. RA Taylor J. K., Boll W., Levy T., Suh E., Siang S., Mantei N., Traber P. G. RT Comparison of intestinal phospholipase A/lysophospholipase and sucrase-isomaltase genes suggest a common structure for enterocyte-specific promoters RL DNA Cell Biol. 16:1419-1428 (1997). RN [8]; RE0047972. RX PUBMED: 10506141. RA Hussain M. A., Habener J. F. RT Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. RL J. Biol. Chem. 274:28950-28957 (1999). XX //