AC T09440
AS T02280.
XX
ID T09440
XX
DT 10.10.2006 (created); sou.
DT 12.05.2016 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA CREB1
XX
SY cAMP-response element binding protein; CRE-like site Binding Protein 36 kDa; CREB; CREB-1; CREB1; CREBalpha; Cyclic AMP Responsive Element Binging factor.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009769 Creb1.
XX
CL C0008; bZIP; 1.1.7.1.1.
XX
CP brain, testis, liver [5]; cerebral cortex, thalamus, hippocampus and cerebellum of both lethargic and non-epileptic control mice (with higher expression in lethargic mice thalamus and cerebral cortex) [16].
XX
FF CREB1 is required for the adipogenesis in 3T3L1 cells [7];
FF acts as a transcriptional repressor of GABA (B) R1a promoter [17];
XX
IN T01318 CBP; mouse, Mus musculus.
IN T10625 Nur77; Mammalia.
XX
MX M07248 V$CREB1_Q3.
MX M03544 V$CREB1_Q6.
MX M00981 V$CREBATF_Q6.
MX M00039 V$CREB_01.
MX M00113 V$CREB_02.
MX M00177 V$CREB_Q2.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00178 V$CREB_Q4.
MX M00917 V$CREB_Q4_01.
MX M00114 V$TAXCREB_01.
MX M00115 V$TAXCREB_02.
XX
BS R22732.
BS R22754.
BS R22912.
BS R16162.
BS R32283.
BS R29920.
BS R40708.
BS R00592.
BS R33536.
BS R56460.
BS R56463.
BS R27212.
BS R64466.
BS R21417.
BS R21255.
BS R34151.
BS R59366.
BS R30100.
BS R69781.
BS R69782.
BS R69786.
BS R69793.
BS R31331.
BS R35870.
BS R24895.
BS R56135.
BS R56418.
BS R20193.
BS R20199.
BS R62412.
BS R04753.
BS R32890.
BS R60366.
BS R30292.
BS R62481.
BS R61571.
BS R34649.
BS R33505.
BS R72208.
BS R66859.
BS R60621.
BS R26831.
BS R37092.
BS R59753.
BS R62964.
BS R29775.
BS R65029.
BS R23528.
BS R29210.
BS R69399.
BS R69450.
BS R69792.
BS R25565.
BS R33384.
BS R35963.
BS R68073.
BS R62339.
BS R65506.
BS R38542.
BS R38543.
BS R64478.
BS R36189.
BS R35858.
BS R35859.
BS R40183.
BS R55833.
BS R73201.
BS R27913.
BS R27605.
BS R63124.
BS R24782.
BS R24786.
BS R04509.
BS R14617.
BS R23090.
BS R60652.
BS R15945.
BS R60978.
BS R26625.
BS R56630.
BS R25569.
BS R25558.
BS R33274.
BS R31857.
BS R31886.
BS R31887.
BS R69788.
BS R69794.
BS R73142.
BS R60243.
BS R39450.
BS R69790.
BS R67428.
BS R30861.
BS R59418.
BS R20716.
BS R60365.
BS R71524.
BS R21219.
BS R16188.
BS R01217.
BS R20838.
BS R09520.
BS R69067.
XX
DR TRANSPATH: MO000088840.
DR TRANSCOMPEL: C00600.
DR UniProtKB: Q01147;
XX
RN [1]; RE0005857.
RX PUBMED: 7969156.
RA Dey A., Minucci S., Ozato K.
RT Ligand-dependent occupancy of the retinoic acid receptor beta2 promoter in vivo
RL Mol. Cell. Biol. 14:8191-8201 (1994).
RN [2]; RE0024467.
RX PUBMED: 12944398.
RA Huber W. E., Price E. R., Widlund H. R., Du J., Davis I. J., Wegner M., Fisher D. E.
RT A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes.
RL J. Biol. Chem. 278:45224-45230 (2003).
RN [3]; RE0025674.
RX PUBMED: 11909979.
RA Wiggin G. R., Soloaga A., Foster J. M., Murray-Tait V., Cohen P., Arthur J. S.
RT MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
RL Mol. Cell. Biol. 22:2871-81 (2002).
RN [4]; RE0030381.
RX PUBMED: 13678586.
RA Marambaud P., Wen P. H., Dutt A., Shioi J., Takashima A., Siman R., Robakis N. K.
RT A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.
RL Cell 114:635-45 (2003).
RN [5]; RE0046855.
RX PUBMED: 11058604.
RA Kumari D., Usdin K.
RT Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome
RL J. Biol. Chem. 276:4357-64 (2001).
RN [6]; RE0048279.
RX PUBMED: 15637148.
RA Ghosh D., Sachdev S., Hannink M., Roberts R. M.
RT Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein.
RL Mol. Endocrinol. 19:1049-1066 (2005).
RN [7]; RE0048847.
RX PUBMED: 14593102.
RA Zhang J. W., Klemm D. J., Vinson C., Lane M. D.
RT Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis.
RL J. Biol. Chem. 279:4471-4478 (2004).
RN [8]; RE0049885.
RX PUBMED: 11754835.
RA Grunwald I. C., Korte M., Wolfer D., Wilkinson G. A., Unsicker K., Lipp H. P., Bonhoeffer T., Klein R.
RT Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity.
RL Neuron 32:1027-1040 (2001).
RN [9]; RE0049976.
RX PUBMED: 17434128.
RA Huang W. C., Ju T. K., Hung M. C., Chen C. C.
RT Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
RL Mol. Cell 26:75-87 (2007).
RN [10]; RE0049979.
RX PUBMED: 15073328.
RA Shi Y., Venkataraman S. L., Dodson G. E., Mabb A. M., LeBlanc S., Tibbetts R. S.
RT Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.
RL Proc. Natl. Acad. Sci. USA 101:5898-5903 (2004).
RN [11]; RE0050277.
RX PUBMED: 17013927.
RA Yang T., Massa S. M., Longo F. M.
RT LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways.
RL J. Neurobiol. 66:1420-1436 (2006).
RN [12]; RE0050739.
RX PUBMED: 15128846.
RA Arthur J. S., Fong A. L., Dwyer J. M., Davare M., Reese E., Obrietan K., Impey S.
RT Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.
RL J. Neurosci. 24:4324-4332 (2004).
RN [13]; RE0051410.
RX PUBMED: 17196532.
RA Sindreu C. B., Scheiner Z. S., Storm D. R.
RT Ca2+ -stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning.
RL Neuron 53:79-89 (2007).
RN [14]; RE0051422.
RX PUBMED: 18003853.
RA Chwang W. B., Arthur J. S., Schumacher A., Sweatt J. D.
RT The nuclear kinase mitogen- and stress-activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation.
RL J. Neurosci. 27:12732-12742 (2007).
RN [15]; RE0051668.
RX PUBMED: 11902114.
RA Perkinton M. S., Ip J. K., Wood G. L., Crossthwaite A. J., Williams R. J.
RT Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.
RL J. Neurochem 80:239-254 (2002).
RN [16]; RE0051671.
RX PUBMED: 11137764.
RA Ishige K., Endo H., Saito H., Ito Y.
RT Repeated administration of CGP 46381, a gamma-aminobutyric acidB antagonist, and ethosuximide suppresses seizure-associated cyclic adenosine 3'5' monophosphate response element- and activator protein-1 DNA-binding activities in lethargic (lh/lh) mice.
RL Neurosci. Lett. 297:207-210 (2001).
RN [17]; RE0051945.
RX PUBMED: 15240803.
RA Steiger J. L., Bandyopadhyay S., Farb D. H., Russek S. J.
RT cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.
RL J. Neurosci. 24:6115-6126 (2004).
RN [18]; RE0053528.
RX PUBMED: 17690094.
RA Yuan W., Pan W., Kong J., Zheng W., Szeto F. L., Wong K. E., Cohen R., Klopot A., Zhang Z., Li Y. C.
RT 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter.
RL J. Biol. Chem. 282:29821-29830 (2007).
RN [19]; RE0054169.
RX PUBMED: 15029245.
RA Tian X., Gotoh T., Tsuji K., Lo E. H., Huang S., Feig L. A.
RT Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.
RL EMBO J. 23:1567-1575 (2004).
RN [20]; RE0054357.
RX PUBMED: 17344422.
RA Shen B., Harrison-Bernard L. M., Fuller A. J., Vanderpool V., Saifudeen Z., El-Dahr S. S.
RT The Bradykinin B2 receptor gene is a target of angiotensin II type 1 receptor signaling.
RL J. Am. Soc. Nephrol. 18:1140-1149 (2007).
RN [21]; RE0055193.
RX PUBMED: 16166097.
RA Lebrun P., Montminy M. R., Van Obberghen E.
RT Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase.
RL J. Biol. Chem. 280:38203-38210 (2005).
RN [22]; RE0055448.
RX PUBMED: 17895242.
RA Weng Z., Signore A. P., Gao Y., Wang S., Zhang F., Hastings T., Yin X. M., Chen J.
RT Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling.
RL J. Biol. Chem. 282:34479-34491 (2007).
RN [23]; RE0055545.
RX PUBMED: 16517600.
RA Duncan E. A., Anest V., Cogswell P., Baldwin A. S.
RT The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.
RL J. Biol. Chem. 281:12521-12525 (2006).
RN [24]; RE0055585.
RX PUBMED: 15870105.
RA Dyson M. H., Thomson S., Inagaki M., Goto H., Arthur S. J., Nightingale K., Iborra F. J., Mahadevan L. C.
RT MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.
RL J. Cell Sci. 118:2247-2259 (2005).
RN [25]; RE0055635.
RX PUBMED: 17855343.
RA Townsend M., Mehta T., Selkoe D. J.
RT Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.
RL J. Biol. Chem. 282:33305-33312 (2007).
RN [26]; RE0056112.
RX PUBMED: 14754893.
RA Sawka-Verhelle D., Escoubet-Lozach L., Fong A. L., Hester K. D., Herzig S., Lebrun P., Glass C. K.
RT PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation.
RL J. Biol. Chem. 279:17772-17784 (2004).
RN [27]; RE0064845.
RX PUBMED: 18334541.
RA Kim H. A., Jeon S. H., Seo G. Y., Park J. B., Kim P. H.
RT TGF-beta1 and IFN-gamma stimulate mouse macrophages to express BAFF via different signaling pathways.
RL J. Leukoc. Biol. 83:1431-1439 (2008).
RN [28]; RE0065317.
RX PUBMED: 19414785.
RA Park J. E., Kim Y. I., Yi A. K.
RT Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway.
RL J. Immunol. 182:6316-6327 (2009).
RN [29]; RE0065342.
RX PUBMED: 18063805.
RA Thomson D. M., Herway S. T., Fillmore N., Kim H., Brown J. D., Barrow J. R., Winder W. W.
RT AMP-activated protein kinase phosphorylates transcription factors of the CREB family.
RL J. Appl. Physiol. 104:429-438 (2008).
RN [30]; RE0065454.
RX PUBMED: 19436069.
RA Wang H., Fukushima H., Kida S., Zhuo M.
RT Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex.
RL J. Biol. Chem. 284:18953-18962 (2009).
RN [31]; RE0065523.
RX PUBMED: 18434517.
RA Wang H., Wu L. J., Zhang F., Zhuo M.
RT Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.
RL J. Neurosci. 28:4385-4397 (2008).
RN [32]; RE0066366.
RX PUBMED: 19389708.
RA Cheli Y., Luciani F., Khaled M., Beuret L., Bille K., Gounon P., Ortonne J. P., Bertolotto C., Ballotti R.
RT {alpha}MSH and Cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism.
RL J. Biol. Chem. 284:18699-18706 (2009).
RN [33]; RE0066510.
RX PUBMED: 15059972.
RA Passeron T., Bahadoran P., Bertolotto C., Chiaverini C., Busca R., Valony G., Bille K., Ortonne J. P., Ballotti R.
RT Cyclic AMP promotes a peripheral distribution of melanosomes and stimulates melanophilin/Slac2-a and actin association.
RL FASEB J. 18:989-991 (2004).
RN [34]; RE0066562.
RX PUBMED: 18037902.
RA Kim J. H., Baek S. H., Kim D. H., Choi T. Y., Yoon T. J., Hwang J. S., Kim M. R., Kwon H. J., Lee C. H.
RT Downregulation of melanin synthesis by haginin A and its application to in vivo lightening model.
RL J. Invest. Dermatol 128:1227-1235 (2008).
RN [35]; RE0067188.
RX PUBMED: 20404334.
RA Iwamoto T., Nakamura T., Doyle A., Ishikawa M., de Vega S., Fukumoto S., Yamada Y.
RT Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation.
RL J. Biol. Chem. 285:18948-18958 (2010).
RN [36]; RE0069084.
RX PUBMED: 12727221.
RA Kang B. H., Jo I., Eun S. Y., Jo S. A.
RT Cyclic AMP-dependent protein kinase A and CREB are involved in neuregulin-induced synapse-specific expression of acetylcholine receptor gene.
RL Biochem. Biophys. Res. Commun. 304:758-765 (2003).
RN [37]; RE0069148.
RX PUBMED: 17553428.
RA Cheng H. Y., Papp J. W., Varlamova O., Dziema H., Russell B., Curfman J. P., Nakazawa T., Shimizu K., Okamura H., Impey S., Obrietan K.
RT microRNA modulation of circadian-clock period and entrainment.
RL Neuron 54:813-829 (2007).
RN [38]; RE0070144.
RX PUBMED: 21478857.
RA Gomes L. C., Benedetto G. D., Scorrano L.
RT During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.
RL Nat. Cell Biol. 13:589-598 (2011).
RN [39]; RE0070662.
RX PUBMED: 21768648.
RA Koyanagi S., Hamdan A. M., Horiguchi M., Kusunose N., Okamoto A., Matsunaga N., Ohdo S.
RT cAMP response element-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene.
RL J. Biol. Chem. 286:32416-32423 (2011).
XX
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