AC T27548
AS T04673.
XX
ID T27548
XX
DT 10.04.2013 (created); spk.
DT 23.09.2014 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA IRF-3
XX
SY Interferon Regulatory Factor 3; IRF-3; IRF3.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002598 IRF3; HGNC: IRF3.
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CL C0022; trp; 3.5.3.0.3.
XX
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T01318 CBP; mouse, Mus musculus.
IN T18378 CBP; human, Homo sapiens.
IN T19903 DEAF1; human, Homo sapiens.
IN T10353 FOXO1A; human, Homo sapiens.
IN T27548 IRF-3; human, Homo sapiens.
IN T05104 IRF-5; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
XX
MX M04014 V$IRF3_07.
MX M01279 V$IRF3_Q3.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
XX
BS R27197.
BS R25556.
BS R14432.
BS R74071.
BS R12443.
BS R12442.
BS R14453.
BS R14454.
BS R25968.
BS R30651.
BS R30654.
BS R30523.
BS R30648.
BS R30649.
BS R14802.
BS R27200.
XX
DR TRANSPATH: MO000285816.
DR TRANSCOMPEL: C00334.
DR TRANSCOMPEL: C00463.
DR UniProtKB: Q14653;
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RN [1]; RE0016765.
RX PUBMED: 10938111.
RA Lin R., Genin P., Mamane Y., Hiscott J.
RT Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
RL Mol. Cell. Biol. 20:6342-6353 (2000).
RN [2]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [3]; RE0024013.
RX PUBMED: 9660935.
RA Wathelet M. G., Lin C. H., Parekh B. S., Ronco L. V., Howley P. M., Maniatis T.
RT Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
RL Mol. Cell 1:507-518 (1998).
RN [4]; RE0024081.
RX PUBMED: 12473110.
RA Yang H., Lin C. H., Ma G., Orr M., Baffi M. O., Wathelet M. G.
RT Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions.
RL Eur. J. Biochem. 269:6142-6151 (2002).
RN [5]; RE0049020.
RX PUBMED: 16301520.
RA Li X. D., Sun L., Seth R. B., Pineda G., Chen Z. J.
RT Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.
RL Proc. Natl. Acad. Sci. USA 102:17717-17722 (2005).
RN [6]; RE0049225.
RX PUBMED: 15841462.
RA Otsuka M., Kato N., Moriyama M., Taniguchi H., Wang Y., Dharel N., kawabe T., Omata M.
RT Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.
RL Hepatology 41:1004-1012 (2005).
RN [7]; RE0049247.
RX PUBMED: 15296650.
RA Miller K., McArdle S., Gale MJ J. r., Geller D. A., Tenoever B., Hiscott J., Gretch D. R., Polyak S. J.
RT Effects of the hepatitis C virus core protein on innate cellular defense pathways.
RL J. Interferon Cytokine Res. 24:391-402 (2004).
RN [8]; RE0049593.
RX PUBMED: 12620797.
RA Ghosh A. K., Majumder M., Steele R., Ray R., Ray R. B.
RT Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1.
RL Virology 306:51-59 (2003).
RN [9]; RE0049614.
RX PUBMED: 15710892.
RA Foy E., Li K., Sumpter R J. r., Loo Y. M., Johnson C. L., Wang C., Fish P. M., Yoneyama M., Fujita T., Lemon S. M., Gale M J. r.
RT Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling.
RL Proc. Natl. Acad. Sci. USA 102:2986-2991 (2005).
RN [10]; RE0053061.
RX PUBMED: 17296604.
RA Johnson J., Albarani V., Nguyen M., Goldman M., Willems F., Aksoy E.
RT Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.
RL J. Biol. Chem. 282:15022-15032 (2007).
RN [11]; RE0053664.
RX PUBMED: 16125763.
RA Seth R. B., Sun L., Ea C. K., Chen Z. J.
RT Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
RL Cell 122:669-682 (2005).
RN [12]; RE0054266.
RX PUBMED: 15367631.
RA tenOever B. R., Sharma S., Zou W., Sun Q., Grandvaux N., Julkunen I., Hemmi H., Yamamoto M., Akira S., Yeh W. C., Lin R., Hiscott J.
RT Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
RL J. Virol. 78:10636-10649 (2004).
RN [13]; RE0054415.
RX PUBMED: 17190814.
RA Saito T., Hirai R., Loo Y. M., Owen D., Johnson C. L., Sinha S. C., Akira S., Fujita T., Gale M J. r.
RT Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
RL Proc. Natl. Acad. Sci. USA 104:582-587 (2007).
RN [14]; RE0054945.
RX PUBMED: 15611223.
RA Sasai M., Oshiumi H., Matsumoto M., Inoue N., Fujita F., Nakanishi M., Seya T.
RT Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation.
RL J. Immunol. 174:27-30 (2005).
RN [15]; RE0055012.
RX PUBMED: 18471880.
RA Dong L. W., Kong X. N., Yan H. X., Yu L. X., Chen L., Yang W., Liu Q., Huang D. D., Wu M. C., Wang H. Y.
RT Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.
RL Mol. Immunol. 45:3025-3035 (2008).
RN [16]; RE0055029.
RX PUBMED: 18641315.
RA Higgs R., Ni Gabhann J., Ben Larbi N., Breen E. P., Fitzgerald K. A., Jefferies C. A.
RT The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.
RL J. Immunol. 181:1780-1786 (2008).
RN [17]; RE0055057.
RX PUBMED: 15502848.
RA Sarkar S. N., Peters K. L., Elco C. P., Sakamoto S., Pal S., Sen G. C.
RT Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.
RL Nat. Struct. Mol. Biol. 11:1060-1067 (2004).
RN [18]; RE0055079.
RX PUBMED: 16699525.
RA Saitoh T., Tun-Kyi A., Ryo A., Yamamoto M., Finn G., Fujita T., Akira S., Yamamoto N., Lu K. P., Yamaoka S.
RT Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.
RL Nat. Immunol. 7:598-605 (2006).
RN [19]; RE0055115.
RX PUBMED: 15661910.
RA Saitoh T., Yamamoto M., Miyagishi M., Taira K., Nakanishi M., Fujita T., Akira S., Yamamoto N., Yamaoka S.
RT A20 is a negative regulator of IFN regulatory factor 3 signaling.
RL J. Immunol. 174:1507-1512 (2005).
RN [20]; RE0063172.
RX PUBMED: 18209079.
RA Eskan M. A., Rose B. G., Benakanakere M. R., Lee M. J., Kinane D. F.
RT Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells.
RL J. Immunol. 180:1818-1825 (2008).
RN [21]; RE0064765.
RX PUBMED: 17653195.
RA Malathi K., Dong B., Gale M J. r., Silverman R. H.
RT Small self-RNA generated by RNase L amplifies antiviral innate immunity.
RL Nature 448:816-819 (2007).
RN [22]; RE0064832.
RX PUBMED: 19543380.
RA Delaloye J., Roger T., Steiner-Tardivel Q. G., Le Roy D., Knaup Reymond M., Akira S., Petrilli V., Gomez C. E., Perdiguero B., Tschopp J., Pantaleo G., Esteban M., Calandra T.
RT Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.
RL PLoS Pathog. 5:e1000480 (2009).
RN [23]; RE0065024.
RX PUBMED: 19893624.
RA Nakhaei P., Mesplede T., Solis M., Sun Q., Zhao T., Yang L., Chuang T. H., Ware C. F., Lin R., Hiscott J.
RT The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
RL PLoS Pathog. 5:e1000650 (2009).
RN [24]; RE0068547.
RX PUBMED: 18684960.
RA Kalali B. N., Kollisch G., Mages J., Muller T., Bauer S., Wagner H., Ring J., Lang R., Mempel M., Ollert M.
RT Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling.
RL J. Immunol. 181:2694-2704 (2008).
RN [25]; RE0069935.
RX PUBMED: 21285412.
RA Koshiba T., Yasukawa K., Yanagi Y., Kawabata S.
RT Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling.
RL Sci. Signal. 4:ra7 (2011).
RN [26]; RE0070654.
RX PUBMED: 21336305.
RA Liu F., Wu S., Ren H., Gu J.
RT Klotho suppresses RIG-I-mediated senescence-associated inflammation.
RL Nat. Cell Biol. 13:254-262 (2011).
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