AC T05104
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ID T05104
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DT 14.05.2002 (created); mas.
DT 27.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA IRF-5
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SY Interferon Regulatory Factor 5; IRF-5; IRF5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003135 IRF5; HGNC: IRF5.
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CL C0022; trp; 3.5.3.0.5.
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SF phosphorylation experimentally proven which is caused for example by infection of the corresponding cells with NDV (Newcastle disease virus) [1];
SF IAD domain, conserved within IRF family, is responsible for protein-protein interactions [3];
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CP (adult:) spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [1].
EX bone marrow,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX colon,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX liver,,,fetal; none; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX lymph node,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX prostate gland,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX uterus,,,adult; none; Northern blot; mRNA (poly-A); [1].
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FF nuclear translocation is obviously regulated: infection with NDV (Newcastle disease virus) but not with Sendai virus leads to nuclear translocation (in 2fTGH cells) [1];
FF does not bind to or stimulate promoter of IRF-7 gene G002599 [1];
FF regulates different subset of IFNA genes compared to IRF-7 : activates expression of IFNA8 G004118, IFNA2 G001235, IFNA3 G004116, and IFNA17 G004117 genes [1];
FF expression of a mammalian IRF-5 ortholog is regulated by p53 [2];
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IN T34265 COPS2; human, Homo sapiens.
IN T27548 IRF-3; human, Homo sapiens.
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MX M04017 V$IRF5_06.
MX M03875 V$IRF5_Q3.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R25556.
BS R25968.
BS R66505.
BS R71760.
BS R71764.
BS R71773.
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DR TRANSPATH: MO000031282.
DR UniProtKB: Q13568;
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RN [1]; RE0017773.
RX PUBMED: 11303025.
RA Barnes B. J., Moore P. A., Pitha P. M.
RT Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.
RL J. Biol. Chem. 276:23382-23390 (2001).
RN [2]; RE0017792.
RX PUBMED: 11973653.
RA Mori T., Anazawa Y., Iiizumi M., Fukuda S., Nakamura Y., Arakawa H.
RT Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53
RL Oncogene 21:2914-2918 (2002).
RN [3]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [4]; RE0064916.
RX PUBMED: 15695821.
RA Schoenemeyer A., Barnes B. J., Mancl M. E., Latz E., Goutagny N., Pitha P. M., Fitzgerald K. A., Golenbock D. T.
RT The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
RL J. Biol. Chem. 280:17005-17012 (2005).
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