AC T10353
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ID T10353
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DT 30.01.2003 (created); mkl.
DT 17.05.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA FOXO1A
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SY FKH1; FKHR; forkhead box O1A (rhabdomyosarcoma); FOXO1; FOXO1A.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004744 FOXO1; HGNC: FOXO1.
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CL C0023; fork head; 3.3.1.15.1.
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FF FoxO1 is a novel transcription factor [15];
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IN T18378 CBP; human, Homo sapiens.
IN T08875 Cdk2-isoform1; human, Homo sapiens.
IN T01488 Cdk2; human, Homo sapiens.
IN T27548 IRF-3; human, Homo sapiens.
IN T18012 SIR2L6; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
IN T30562 tuberin; human, Homo sapiens.
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MX M07286 V$FOXO1A_Q3.
MX M03823 V$FOXO1A_Q5.
MX M00473 V$FOXO1_01.
MX M00474 V$FOXO1_02.
MX M01968 V$FOXO1_03.
MX M01969 V$FOXO1_04.
MX M04255 V$FOXO1_05.
MX M04257 V$FOXO1_07.
MX M01216 V$FOXO1_Q5.
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BS R37432.
BS R09923.
BS R70242.
BS R64969.
BS R63083.
BS R12332.
BS R61613.
BS R61614.
BS R61615.
BS R29249.
BS R73092.
BS R73093.
BS R62637.
BS R62639.
BS R26506.
BS R30829.
BS R30830.
BS R57531.
BS R63648.
BS R63649.
BS R67662.
BS R67674.
BS R67655.
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DR TRANSPATH: MO000034454.
DR UniProtKB: Q12778;
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RN [1]; RE0030982.
RX PUBMED: 15084259.
RA Seoane J., Le H. V., Shen L., Anderson S. A., Massague J.
RT Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
RL Cell 117:211-23 (2004).
RN [2]; RE0033289.
RX PUBMED: 15220471.
RA Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., Fukamizu A.
RT Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 101:10042-7 (2004).
RN [3]; RE0048309.
RX PUBMED: 15668399.
RA Huang H., Regan K. M., Wang F., Wang D., Smith D. I., van Deursen J. M., Tindall D. J.
RT Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
RL Proc. Natl. Acad. Sci. USA 102:1649-1654 (2005).
RN [4]; RE0048557.
RX PUBMED: 16690615.
RA Funes M., Miller J. K., Lai C., Carraway KL 3. r. d., Sweeney C.
RT The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3.
RL J. Biol. Chem. 281:19310-19319 (2006).
RN [5]; RE0055715.
RX PUBMED: 18006475.
RA Dixit M., Bess E., Fisslthaler B., Hartel F. V., Noll T., Busse R., Fleming I.
RT Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells.
RL Cardiovasc. Res. 77:160-168 (2008).
RN [6]; RE0055916.
RX PUBMED: 11311120.
RA Woods Y. L., Rena G., Morrice N., Barthel A., Becker W., Guo S., Unterman T. G., Cohen P.
RT The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
RL Biochem. J. 355:597-607 (2001).
RN [7]; RE0055918.
RX PUBMED: 17717603.
RA Kitamura T., Kitamura Y. I., Funahashi Y., Shawber C. J., Castrillon D. H., Kollipara R., DePinho R. A., Kitajewski J., Accili D.
RT A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
RL J. Clin. Invest. 117:2477-2485 (2007).
RN [8]; RE0056059.
RX PUBMED: 18356527.
RA Yuan Z., Becker E. B., Merlo P., Yamada T., DiBacco S., Konishi Y., Schaefer E. M., Bonni A.
RT Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
RL Science 319:1665-1668 (2008).
RN [9]; RE0056060.
RX PUBMED: 17038621.
RA Huang H., Regan K. M., Lou Z., Chen J., Tindall D. J.
RT CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
RL Science 314:294-297 (2006).
RN [10]; RE0070180.
RX PUBMED: 20543840.
RA Zhao Y., Yang J., Liao W., Liu X., Zhang H., Wang S., Wang D., Feng J., Yu L., Zhu W. G.
RT Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
RL Nat. Cell Biol. 12:665-675 (2010).
RN [11]; RE0070721.
RX PUBMED: 20685959.
RA Yang X., Nath A., Opperman M. J., Chan C.
RT The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.
RL Mol. Biol. Cell 21:3449-3458 (2010).
RN [12]; RE0070940.
RX PUBMED: 21148296.
RA Wang Q., Zhou Y., Jackson L. N., Johnson S. M., Chow C. W., Evers B. M.
RT Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation.
RL Mol. Biol. Cell 22:412-420 (2011).
RN [13]; RE0071351.
RX PUBMED: 21282515.
RA Shim E. K., Jung S. H., Lee J. R.
RT Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells.
RL J. Immunol. 186:2926-2935 (2011).
RN [14]; RE0072074.
RX PUBMED: 21177856.
RA Lee J. W., Chen H., Pullikotil P., Quon M. J.
RT Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.
RL J. Biol. Chem. 286:6423-6432 (2011).
RN [15]; RE0064198.
RX PUBMED: 18390843.
RA Han C. Y., Cho K. B., Choi H. S., Han H. K., Kang K. W.
RT Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells.
RL Carcinogenesis 29:1837-1844 (2008).
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