AC T30562
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ID T30562
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DT 26.11.2003 (created); cch.
DT 17.12.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA tuberin
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SY LAM; Tsc2; tuberous sclerosis 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009038 TSC2; HGNC: TSC2.
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EX cerebral cortex,,,adult; high; immunoprecipitation; protein; [16].
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IN T10353 FOXO1A; human, Homo sapiens.
IN T14067 FOXO1A; Mammalia.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T00885 VDR; human, Homo sapiens.
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BS R61637.
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DR TRANSPATH: MO000038073.
DR UniProtKB: P49815;
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RN [1]; RE0023566.
RX PUBMED: 7608212.
RA Wienecke R., Konig A., DeClue J. E.
RT Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity.
RL J. Biol. Chem. 270:16409-16414 (1995).
RN [2]; RE0048536.
RX PUBMED: 16357142.
RA Zacharek S. J., Xiong Y., Shumway S. D.
RT Negative regulation of TSC1-TSC2 by mammalian D-type cyclins.
RL Cancer Res. 65:11354-11360 (2005).
RN [3]; RE0048799.
RX PUBMED: 14690447.
RA Surpili M. J., Delben T. M., Kobarg J.
RT Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.
RL Biochemistry 42:15369-15376 (2003).
RN [4]; RE0051900.
RX PUBMED: 17693255.
RA Lee D. F., Kuo H. P., Chen C. T., Hsu J. M., Chou C. K., Wei Y., Sun H. L., Li L. Y., Ping B., Huang W. C., He X., Hung J. Y., Lai C. C., Ding Q., Su J. L., Yang J. Y., Sahin A. A., Hortobagyi G. N., Tsai F. J., Tsai C. H., Hung M. C.
RT IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
RL Cell 130:440-455 (2007).
RN [5]; RE0063041.
RX PUBMED: 15988001.
RA Sofer A., Lei K., Johannessen C. M., Ellisen L. W.
RT Regulation of mTOR and cell growth in response to energy stress by REDD1.
RL Mol. Cell. Biol. 25:5834-5845 (2005).
RN [6]; RE0066737.
RX PUBMED: 19648120.
RA Mahimainathan L., Ghosh-Choudhury N., Venkatesan B., Das F., Mandal C. C., Dey N., Habib S. L., Kasinath B. S., Abboud H. E., Ghosh Choudhury G.
RT TSC2 deficiency increases PTEN via HIF1alpha.
RL J. Biol. Chem. 284:27790-27798 (2009).
RN [7]; RE0067779.
RX PUBMED: 15963462.
RA Nellist M., Burgers P. C., van den Ouweland A. M., Halley D. J., Luider T. M.
RT Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.
RL Biochem. Biophys. Res. Commun. 333:818-826 (2005).
RN [8]; RE0067781.
RX PUBMED: 17989114.
RA Habib S. L., Riley D. J., Mahimainathan L., Bhandari B., Choudhury G. G., Abboud H. E.
RT Tuberin regulates the DNA repair enzyme OGG1.
RL Am. J. Physiol. Renal Physiol. 294:F281-90 (2008).
RN [9]; RE0068183.
RX PUBMED: 9580671.
RA van Slegtenhorst M., Nellist M., Nagelkerken B., Cheadle J., Snell R., van den Ouweland A., Reuser A., Sampson J., Halley D., van der Sluijs P.
RT Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.
RL Hum. Mol. Genet. 7:1053-1057 (1998).
RN [10]; RE0068812.
RX PUBMED: 14651849.
RA Inoki K., Zhu T., Guan K. L.
RT TSC2 mediates cellular energy response to control cell growth and survival.
RL Cell 115:577-590 (2003).
RN [11]; RE0068982.
RX PUBMED: 15854902.
RA Long X., Lin Y., Ortiz-Vega S., Yonezawa K., Avruch J.
RT Rheb binds and regulates the mTOR kinase.
RL Curr. Biol. 15:702-713 (2005).
RN [12]; RE0069663.
RX PUBMED: 18454141.
RA Tasdemir E., Maiuri M. C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., Nannmark U., Samara C., Pinton P., Vicencio J. M., Carnuccio R., Moll U. M., Madeo F., Paterlini-Brechot P., Rizzuto R., Szabadkai G., Pierron G., Blomgren K., Tavernarakis N., Codogno P., Cecconi F., Kroemer G.
RT Regulation of autophagy by cytoplasmic p53.
RL Nat. Cell Biol. 10:676-687 (2008).
RN [13]; RE0070180.
RX PUBMED: 20543840.
RA Zhao Y., Yang J., Liao W., Liu X., Zhang H., Wang S., Wang D., Feng J., Yu L., Zhu W. G.
RT Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
RL Nat. Cell Biol. 12:665-675 (2010).
RN [14]; RE0070446.
RX PUBMED: 18692468.
RA Budanov A. V., Karin M.
RT p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
RL Cell 134:451-460 (2008).
RN [15]; RE0072950.
RX PUBMED: 20618440.
RA Pozuelo-Rubio M.
RT Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
RL FEBS J. 277:3321-3342 (2010).
RN [16]; RE0023570.
RX PUBMED: 12176984.
RA Nellist M., Goedbloed M. A., de Winter C., Verhaaf B., Jankie A., Reuser A. J., van den Ouweland A. M., van der Sluijs P., Halley D. J.
RT Identification and characterization of the interaction between tuberin and 14-3-3zeta.
RL J. Biol. Chem. 277:39417-39424 (2002).
RN [17]; RE0023647.
RX PUBMED: 12511557.
RA Mak B. C., Takemaru K., Kenerson H. L., Moon R. T., Yeung R. S.
RT The tuberin-hamartin complex negatively regulates beta-catenin signaling activity.
RL J. Biol. Chem. 278:5947-5951 (2003).
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