AC T08875
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ID T08875
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DT 27.04.2006 (created); anu.
DT 22.07.2011 (updated); pos.
CO Copyright (C), QIAGEN.
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FA Cdk2-isoform1
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SY cyclin-dependent kinase 2; p33(cdk2).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009981 CDK2; HGNC: CDK2.
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SZ 298 AA; 33.9 kDa (cDNA) (calc.).
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SQ MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
SQ PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
SQ HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
SQ STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
SQ PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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SC translated from EMBL:BT006821
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IN T04074 brca1; human, Homo sapiens.
IN T02936 FOXO1A; human, Homo sapiens.
IN T10353 FOXO1A; human, Homo sapiens.
IN T34249 p21Cip1; human, Homo sapiens.
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DR TRANSPATH: MO000080771.
DR EMBL: BT006821;
DR EMBL: X61622;
DR UniProtKB: P24941;
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RN [1]; RE0017514.
RX PUBMED: 11584018.
RA Santaguida M., Ding Q., Berube G., Truscott M., Whyte P., Nepveu A.
RT Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).
RL J. Biol. Chem. 276:45780-45790 (2001).
RN [2]; RE0047651.
RX PUBMED: 16174846.
RA Frouin I., Toueille M., Ferrari E., Shevelev I., Hubscher U.
RT Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen.
RL Nucleic Acids Res. 33:5354-5361 (2005).
RN [3]; RE0048082.
RX PUBMED: 9244350.
RA Wang H., Shao N., Ding Q. M., Cui J., Reddy E. S., Rao V. N.
RT BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
RL Oncogene 15:143-157 (1997).
RN [4]; RE0048951.
RX PUBMED: 16343435.
RA Oh Y. T., Chun K. H., Oh J. I., Park J. A., Kim Y. U., Lee S. K.
RT PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis.
RL Biochem. Biophys. Res. Commun. 339:1138-1147 (2006).
RN [5]; RE0052681.
RX PUBMED: 9111314.
RA Sandhu C., Garbe J., Bhattacharya N., Daksis J., Pan C. H., Yaswen P., Koh J., Slingerland J. M., Stampfer M. R.
RT Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells.
RL Mol. Cell. Biol. 17:2458-2467 (1997).
RN [6]; RE0056060.
RX PUBMED: 17038621.
RA Huang H., Regan K. M., Lou Z., Chen J., Tindall D. J.
RT CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
RL Science 314:294-297 (2006).
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