AC T05824
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ID T05824
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DT 30.01.2004 (created); oke.
DT 15.11.2007 (updated); sba.
CO Copyright (C), QIAGEN.
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FA CREST
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SY calcium-regulated transcription coactivator; CBP interacting protein.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009136 Ss18l1.
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SF related to the co-activator SYT and belongs to the CREST/SYT family [1];
SF N-terminal domain suppresses transactivation in unstimulated neurons [1];
SF C-terminal domain is required for calcium-induced transactivation [1];
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CP developing brain: cerebral cortex (E18 to P10, with a peak at P1), cortical neurons [1]; E18 stage: forebrain, midbrain, hindbrain [1]; adult: enriched in the brain, also present in the heart, liver, kidney, and testis [1]; [1].
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FF co-activator [1];
FF activates transcription in response to calcium influx, neurotransmitter glutamate, membrane depolarization [1];
FF directly interacts with co-activator CBP, which contributes to calcium-induced transactivation [1];
FF involved in regulation of nervous system development [1];
FF regulates calcium-induced dendritic growth [1];
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IN T01318 CBP; mouse, Mus musculus.
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DR TRANSPATH: MO000038534.
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RN [1]; RE0023768.
RX PUBMED: 14716005.
RA Aizawa H., Hu S. C., Bobb K., Balakrishnan K., Ince G., Gurevich I., Cowan M., Ghosh A.
RT Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.
RL Science 303:197-202 (2004).
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