AC T17772
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ID T17772
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DT 03.04.2002 (created); cch.
DT 17.02.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA p53{pS15}
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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EX human, Homo sapiens,T-lymphocyte,,adult; detectable; Western blot; protein; [5].
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FF p53 is phosphorylated on Ser15 in response to heat shock, gamma and UV radiation [4];
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IN T01318 CBP; mouse, Mus musculus.
IN T28121 SMAR1; Mammalia.
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BS R66303.
BS R31328.
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DR TRANSPATH: MO000030925.
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RN [1]; RE0020896.
RX PUBMED: 10432310.
RA Craig A. L., Burch L., Vojtesek B., Mikutowska J., Thompson A., Hupp T. R.
RT Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
RL Biochem. J. 342:133-141 (1999).
RN [2]; RE0020918.
RX PUBMED: 11875057.
RA Saito S., Goodarzi A. A., Higashimoto Y., Noda Y., Lees-Miller S. P., Appella E., Anderson C. W.
RT ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation
RL J. Biol. Chem. 277:12491-12494 (2002).
RN [3]; RE0020930.
RX PUBMED: 11447225.
RA Xie S., Wang Q., Wu H., Cogswell J., Lu L., Jhanwar-Uniyal M., Dai W.
RT Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3
RL J. Biol. Chem. 276:36194-36199 (2001).
RN [4]; RE0020946.
RX PUBMED: 11850826.
RA Miyakoda M., Suzuki K., Kodama S., Watanabe M.
RT Activation of ATM and phosphorylation of p53 by heat shock
RL Oncogene 21:1090-1096 (2002).
RN [5]; RE0021333.
RX PUBMED: 11099484.
RA Genini D., Sheeter D., Rought S., Zaunders J. J., Susin S. A., Kroemer G., Richman D. D., Carson D. A., Corbeil J., Leoni L. M.
RT HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism
RL FASEB J. 15:5-6 (2001).
RN [6]; RE0030307.
RX PUBMED: 12773400.
RA Foray N., Marot D., Gabriel A., Randrianarison V., Carr A. M., Perricaudet M., Ashworth A., Jeggo P.
RT A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
RL EMBO J. 22:2860-71 (2003).
RN [7]; RE0047502.
RX PUBMED: 16024799.
RA Pedeux R., Sengupta S., Shen J. C., Demidov O. N., Saito S., Onogi H., Kumamoto K., Wincovitch S., Garfield S. H., McMenamin M., Nagashima M., Grossman S. R., Appella E., Harris C. C.
RT ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.
RL Mol. Cell. Biol. 25:6639-6648 (2005).
RN [8]; RE0048945.
RX PUBMED: 15668906.
RA Weebadda W. K., Jackson T. J., Lin A. W.
RT Expression of p16INK4A variants in senescent human fibroblasts independent of protein phosphorylation.
RL J. Cell. Biochem. 94:1135-1147 (2005).
RN [9]; RE0049046.
RX PUBMED: 16777994.
RA Tyagi A., Singh R. P., Agarwal C., Agarwal R.
RT Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
RL Carcinogenesis 27:2269-2280 (2006).
RN [10]; RE0049448.
RX PUBMED: 12381304.
RA Schon O., Friedler A., Bycroft M., Freund S. M., Fersht A. R.
RT Molecular mechanism of the interaction between MDM2 and p53.
RL J. Mol. Biol. 323:491-501 (2002).
RN [11]; RE0049893.
RX PUBMED: 16801388.
RA Yim H., Hwang I. S., Choi J. S., Chun K. H., Jin Y. H., Ham Y. M., Lee K. Y., Lee S. K.
RT Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.
RL J. Cell Biol. 174:77-88 (2006).
RN [12]; RE0049918.
RX PUBMED: 16293623.
RA Dodson G. E., Tibbetts R. S.
RT DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
RL J. Biol. Chem. 281:1692-1697 (2006).
RN [13]; RE0049956.
RX PUBMED: 16849690.
RA Wang J., Pabla N., Wang C. Y., Wang W., Schoenlein P. V., Dong Z.
RT Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53.
RL Am. J. Physiol. Renal Physiol. 291:F1300-7 (2006).
RN [14]; RE0050014.
RX PUBMED: 15533933.
RA Helt C. E., Cliby W. A., Keng P. C., Bambara R. A., O'Reilly M. A.
RT Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.
RL J. Biol. Chem. 280:1186-1192 (2005).
RN [15]; RE0050302.
RX PUBMED: 15159397.
RA Fabbro M., Savage K., Hobson K., Deans A. J., Powell S. N., McArthur G. A., Khanna K. K.
RT BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
RL J. Biol. Chem. 279:31251-31258 (2004).
RN [16]; RE0050487.
RX PUBMED: 16452482.
RA Aglipay J. A., Martin S. A., Tawara H., Lee S. W., Ouchi T.
RT ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
RL J. Biol. Chem. 281:9710-9718 (2006).
RN [17]; RE0050948.
RX PUBMED: 17054906.
RA Ozaki T., Li Y., Kikuchi H., Tomita T., Iwatsubo T., Nakagawara A.
RT The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.
RL Biochem. Biophys. Res. Commun. 351:57-63 (2006).
RN [18]; RE0055560.
RX PUBMED: 18715874.
RA Cao C., Lu S., Kivlin R., Wallin B., Card E., Bagdasarian A., Tamakloe T., Chu W. M., Guan K. L., Wan Y.
RT AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes.
RL J. Biol. Chem. 283:28897-28908 (2008).
RN [19]; RE0064036.
RX PUBMED: 18449195.
RA Richard D. J., Bolderson E., Cubeddu L., Wadsworth R. I., Savage K., Sharma G. G., Nicolette M. L., Tsvetanov S., McIlwraith M. J., Pandita R. K., Takeda S., Hay R. T., Gautier J., West S. C., Paull T. T., Pandita T. K., White M. F., Khanna K. K.
RT Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
RL Nature 453:677-681 (2008).
RN [20]; RE0064643.
RX PUBMED: 17684018.
RA Selvendiran K., Tong L., Vishwanath S., Bratasz A., Trigg N. J., Kutala V. K., Hideg K., Kuppusamy P.
RT EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression.
RL J. Biol. Chem. 282:28609-28618 (2007).
RN [21]; RE0065167.
RX PUBMED: 19377469.
RA Tian C., Xing G., Xie P., Lu K., Nie J., Wang J., Li L., Gao M., Zhang L., He F.
RT KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.
RL Nat. Cell Biol. 11:580-591 (2009).
RN [22]; RE0065863.
RX PUBMED: 16160161.
RA Boutell C., Canning M., Orr A., Everett R. D.
RT Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.
RL J. Virol. 79:12342-12354 (2005).
RN [23]; RE0066671.
RX PUBMED: 19026785.
RA Yang G., Li Y., Nishimura E. K., Xin H., Zhou A., Guo Y., Dong L., Denning M. F., Nickoloff B. J., Cui R.
RT Inhibition of PAX3 by TGF-beta modulates melanocyte viability.
RL Mol. Cell 32:554-563 (2008).
RN [24]; RE0067666.
RX PUBMED: 15866171.
RA Jones R. G., Plas D. R., Kubek S., Buzzai M., Mu J., Xu Y., Birnbaum M. J., Thompson C. B.
RT AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
RL Mol. Cell 18:283-293 (2005).
RN [25]; RE0068818.
RX PUBMED: 17936559.
RT The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
RL Cancer Cell 12:342-354 (2007).
RN [26]; RE0069578.
RX PUBMED: 20962272.
RA Lee C. W., Ferreon J. C., Ferreon A. C., Arai M., Wright P. E.
RT Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation.
RL Proc. Natl. Acad. Sci. USA 107:19290-19295 (2010).
RN [27]; RE0069739.
RX PUBMED: 21383020.
RA Ling S., Lin W. C.
RT EDD inhibits ATM-mediated phosphorylation of P53.
RL J. Biol. Chem. 286:14972-14982 (2011).
RN [28]; RE0069932.
RX PUBMED: 12556884.
RA Bakkenist C. J., Kastan M. B.
RT DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
RL Nature 421:499-506 (2003).
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