AC T01733
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ID T01733
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DT 11.03.1996 (created); ewi.
DT 03.03.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA HOXB6
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SY Ghox-2.2 (chick); homeo box B6; Hox-2.2; Hoxb-6; HOXB6; MH-22A; XlHox2.2 (Xenopus).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014499 Hoxb6.
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HO Antp (Drosophila).
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CL C0006; homeo; 3.1.1.6.2.
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FF may play a role in the development of the CNS, vertebrae, and limbs [5];
FF homozygous mutants lack the first rib and have a split second one, also reveal anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1 [1];
FF the latter is also found in HOXB5/B6 transheterozygotes (nonallelic noncomplementation), indicating that both genes have to cooperate [1];
FF a 3600 bp promoter fragment governs he HOXB6 spatiotemporal expression pattern [5];
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IN T01318 CBP; mouse, Mus musculus.
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MX M01460 V$HOXB6_01.
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DR TRANSPATH: MO000046054.
DR UniProtKB: P09023; HXB6_MOUSE.
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RN [1]; RE0003954.
RX PUBMED: 7828847.
RA Rancourt D. E., Tsuzuki T., Capecchi M. R.
RT Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation
RL Genes Dev. 9:108-122 (1995).
RN [2]; RE0003955.
RX PUBMED: 1672751.
RA Shen W. F., Detmer K., Simonitch Eason T. A., Lawrence H. J., Largman C.
RT Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues
RL Nucleic Acids Res. 19:539-545 (1991).
RN [3]; RE0003958.
RX PUBMED: 2890503.
RA Lonai P., Arman E., Czosnek H., Ruddle F. H., Blatt C.
RT New murine homeoboxes: Structure, chromosomal assignment, and differential expression in adult erythropoiesis
RL DNA 6:409-418 (1987).
RN [4]; RE0003959.
RX PUBMED: 2891608.
RA Hart C. P., Fainsod A., Ruddle F. H.
RT Sequence analysis of the murine Hox 2.2, 2.3, and 2.4 homeo boxes: Evolutionary and structural comparisons
RL Genomics 1:182-195 (1987).
RN [5]; RE0003962.
RX PUBMED: 1935690.
RA Schughart K., Bieberich C. J., Eid R., Ruddle F. H.
RT A regulatory region from the mouse Hox-2.2 promoter directs gene expression into developing limbs
RL Development 112:807-811 (1991).
RN [6]; RE0048848.
RX PUBMED: 15269212.
RA Shen W., Chrobak D., Krishnan K., Lawrence H. J., Largman C.
RT HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process.
RL J. Biol. Chem. 279:39895-39904 (2004).
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