AC T17931
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ID T17931
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DT 19.09.2007 (created); bch.
DT 02.02.2012 (updated); mka.
CO Copyright (C), QIAGEN.
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FA FXR:RXR-alpha
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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IN T04632 SRC-1; human, Homo sapiens.
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MX M07256 V$FXRRXR_Q5.
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BS R31843.
BS R31902.
BS R09968.
BS R31885.
BS R27954.
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DR TRANSPATH: MO000114090.
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RN [1]; RE0016189.
RX PUBMED: 7774010.
RA Forman B. M., Goode E., Chen J., Oro A. E., Bradley D. J., Perlmann T., Noonan D. J., Burka L. T., McMorris T., Lamph W. W., et a. l.
RT Identification of a nuclear receptor that is activated by farnesol metabolites
RL Cell 81:687-693 (1995).
RN [2]; RE0018127.
RX PUBMED: 10360171.
RA Wang H., Chen J., Hollister K., Sowers L. C., Forman B. M.
RT Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.
RL Mol. Cell 3:543-553 (1999).
RN [3]; RE0051119.
RX PUBMED: 10753890.
RA Chiang J. Y., Kimmel R., Weinberger C., Stroup D.
RT Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
RL J. Biol. Chem. 275:10918-10924 (2000).
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