AC T05300
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ID T05300
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DT 23.10.2002 (created); oke.
DT 24.12.2013 (updated); msr.
CO Copyright (C), QIAGEN.
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FA NR1B1:RXR-alpha
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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CL C0002; CC (rec).
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SF heterodimer;
SF for individual polypeptides see human NR1B1 T05299 and human RXR-alpha T01345;
SF heterodimer formation is strictly DNA-dependent [2];
SF RXR binds to the downstream half-site [2];
SF specific protein-DNA interactions are more stable in comparison with RXR homodimers, heterodimers form 11 contacts along DR1 sequence, and homodimers - only 6 contacts [2];
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FF activator in response to retinoic acid [1];
FF binds to DR1 repeats [2];
FF binds to DR5 repeats [1];
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IN T04632 SRC-1; human, Homo sapiens.
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MX M00965 V$DR4_Q2.
MX M08964 V$NR1B1RXRA_01.
MX M00963 V$T3R_Q6.
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BS R19167.
BS R19181.
BS R23650.
BS R10085.
BS R19180.
BS R19185.
BS R33064.
BS R36639.
BS R55881.
BS R55891.
BS R55896.
BS R55898.
BS R21730.
BS R59431.
BS R01321.
BS R27355.
BS R27490.
BS R27350.
BS R42096.
BS R13071.
BS R19188.
BS R26751.
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DR TRANSPATH: MO000033905.
DR TRANSCOMPEL: C00361.
DR TRANSCOMPEL: C00366.
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RN [1]; RE0016840.
RX PUBMED: 9799805.
RA Crestani M., Sadeghpour A., Stroup D., Galli G., Chiang J. Y.
RT Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
RL J. Lipid Res. 39:2192-2200 (1998).
RN [2]; RE0022229.
RX PUBMED: 10698945.
RA Rastinejad F., Wagner T., Zhao Q., Khorasanizadeh S.
RT Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
RL EMBO J. 19:1045-1054 (2000).
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