TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05300 XX ID T05300 XX DT 23.10.2002 (created); oke. DT 24.12.2013 (updated); msr. CO Copyright (C), QIAGEN. XX FA NR1B1:RXR-alpha XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX CL C0002; CC (rec). XX SF heterodimer; SF for individual polypeptides see human NR1B1 T05299 and human RXR-alpha T01345; SF heterodimer formation is strictly DNA-dependent [2]; SF RXR binds to the downstream half-site [2]; SF specific protein-DNA interactions are more stable in comparison with RXR homodimers, heterodimers form 11 contacts along DR1 sequence, and homodimers - only 6 contacts [2]; XX FF activator in response to retinoic acid [1]; FF binds to DR1 repeats [2]; FF binds to DR5 repeats [1]; XX IN T04632 SRC-1; human, Homo sapiens. XX MX M00965 V$DR4_Q2. MX M08964 V$NR1B1RXRA_01. MX M00963 V$T3R_Q6. XX BS R19167. BS R19181. BS R23650. BS R10085. BS R19180. BS R19185. BS R33064. BS R36639. BS R55881. BS R55891. BS R55896. BS R55898. BS R21730. BS R59431. BS R01321. BS R27355. BS R27490. BS R27350. BS R42096. BS R13071. BS R19188. BS R26751. XX DR TRANSPATH: MO000033905. DR TRANSCOMPEL: C00361. DR TRANSCOMPEL: C00366. XX RN [1]; RE0016840. RX PUBMED: 9799805. RA Crestani M., Sadeghpour A., Stroup D., Galli G., Chiang J. Y. RT Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors. RL J. Lipid Res. 39:2192-2200 (1998). RN [2]; RE0022229. RX PUBMED: 10698945. RA Rastinejad F., Wagner T., Zhao Q., Khorasanizadeh S. RT Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1. RL EMBO J. 19:1045-1054 (2000). XX //