AC T08949
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ID T08949
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DT 08.03.2006 (created); man.
DT 16.06.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA PXR
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SY BXR; NR1I2; nuclear receptor subfamily 1, group I, member 2; ONR1; PAR; PAR2; PARq; pregnane X receptor; PRR; PXR; SAR; steroid and xenobiotic receptor; SXR.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002750 NR1I2; HGNC: NR1I2.
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CL C0002; CC (rec); 2.1.2.4.2.
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IN T08562 CREB1; human, Homo sapiens.
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T16208 PGC-1; human, Homo sapiens.
IN T01516 Pit-1B; rat, Rattus norvegicus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01334 RXR-beta; human, Homo sapiens.
IN T04807 RXR-gamma; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
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MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
MX M08779 V$NR1I2_01.
MX M07280 V$NR1NR2_Q3.
MX M00964 V$PXR_Q2.
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BS R29205.
BS R10090.
BS R10853.
BS R19363.
BS R64132.
BS R63993.
BS R63995.
BS R63997.
BS R63998.
BS R63999.
BS R64000.
BS R64001.
BS R64002.
BS R64003.
BS R64004.
BS R64006.
BS R63607.
BS R66314.
BS R66316.
BS R14179.
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DR TRANSPATH: MO000078820.
DR TRANSCOMPEL: C00643.
DR UniProtKB: O75469;
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RN [1]; RE0023245.
RX PUBMED: 11248085.
RA Staudinger J. L., Goodwin B., Jones S. A., Hawkins-Brown D., MacKenzie K. I., LaTour A., Liu Y., Klaassen C. D., Brown K. K., Reinhard J., Willson T. M., Koller B. H., Kliewer S. A.
RT The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
RL Proc. Natl. Acad. Sci. USA 98:3369-3374 (2001).
RN [2]; RE0023316.
RX PUBMED: 12509506.
RA Goodwin B., Gauthier K. C., Umetani M., Watson M. A., Lochansky M. I., Collins J. L., Leitersdorf E., Mangelsdorf D. J., Kliewer S. A., Repa J. J.
RT Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
RL Proc. Natl. Acad. Sci. USA 100:223-228 (2003).
RN [3]; RE0047375.
RX PUBMED: 11891224.
RA Gonzalez M. M., Carlberg C.
RT Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
RL J. Biol. Chem. 277:18501-18509 (2002).
RN [4]; RE0051114.
RX PUBMED: 12016314.
RA Makishima M., Lu T. T., Xie W., Whitfield G. K., Domoto H., Evans R. M., Haussler M. R., Mangelsdorf D. J.
RT Vitamin D receptor as an intestinal bile acid sensor.
RL Science 296:1313-1316 (2002).
RN [5]; RE0051276.
RX PUBMED: 12569201.
RA Dussault I., Yoo H. D., Lin M., Wang E., Fan M., Batta A. K., Salen G., Erickson S. K., Forman B. M.
RT Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.
RL Proc. Natl. Acad. Sci. USA 100:833-838 (2003).
RN [6]; RE0051282.
RX PUBMED: 15489543.
RA Adachi R., Honma Y., Masuno H., Kawana K., Shimomura I., Yamada S., Makishima M.
RT Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative.
RL J. Lipid Res. 46:46-57 (2005).
RN [7]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
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