AC T00513
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ID T00513
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DT 26.01.1993 (created); hse.
DT 27.08.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA MR
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SY mineralcorticoid receptor; mineralocorticoid receptor; MR; NR3C2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009146 NR3C2; HGNC: NR3C2.
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CL C0002; CC (rec); 2.1.1.1.2.
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SF the DBD exhibits 94% homology with that of GR [2];
SF binds glucocorticoids and mineralcorticoids with equal affinity [2];
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FF activator, may mediate mineralocorticoid as well as glucocorticoid-induced transcription [2];
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IN T05076 GR; human, Homo sapiens.
IN T04922 Prox-1; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T19335 TIF1a-short; human, Homo sapiens.
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BS R27057.
BS R30951.
BS R63672.
BS R37862.
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DR TRANSPATH: MO000021449.
DR PATHODB: MT010627.
DR PATHODB: MT010628.
DR PATHODB: MT010629.
DR PATHODB: MT010631.
DR UniProtKB: P08235; MCR_HUMAN.
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RN [1]; RE0001752.
RX PUBMED: 2172797.
RA Forman B. M., Samuels H. H.
RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
RN [2]; RE0002637.
RX PUBMED: 3037703.
RA Arriza J. L., Weinberger C., Cerelli G., Glaser T. M., Handelin B. L., Housman D. E., Evans R. M.
RT Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
RL Science 237:268-275 (1987).
RN [3]; RE0003721.
RX PUBMED: 1655735.
RA Alnemri E. S., Maksymowych A. B., Robertson N.M., Litwack G.
RT Overexpression and characterization of the human mineralocorticoid receptor
RL J. Biol. Chem. 266:18072-18081 (1991).
RN [4]; RE0003722.
RX PUBMED: 1660146.
RA Binart N., Lombes M., Rafestin-Oblin M.-E., Baulieu E.-E.
RT Characterization of human mineralocoticosteroid receptor expressed in the baculovirus system
RL Proc. Natl. Acad. Sci. USA 88:10681-10685 (1991).
RN [5]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [6]; RE0016449.
RX PUBMED: 10428842.
RA Hong H., Yang L., Stallcup M. R.
RT Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3
RL J. Biol. Chem. 274:22618-22626 (1999).
RN [7]; RE0017308.
RX PUBMED: 9115274.
RA Thenot S., Henriquet C., Rochefort H., Cavailles V.
RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
RL J. Biol. Chem. 272:12062-12068 (1997).
RN [8]; RE0031301.
RX PUBMED: 12194973.
RA Planey S. L., Derfoul A., Steplewski A., Robertson N. M., Litwack G.
RT Inhibition of glucocorticoid-induced apoptosis in 697 pre-B lymphocytes by the mineralocorticoid receptor N-terminal domain.
RL J. Biol. Chem. 277:42188-96 (2002).
RN [9]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
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