TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00513 XX ID T00513 XX DT 26.01.1993 (created); hse. DT 27.08.2014 (updated); pro. CO Copyright (C), QIAGEN. XX FA MR XX SY mineralcorticoid receptor; mineralocorticoid receptor; MR; NR3C2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G009146 NR3C2; HGNC: NR3C2. XX CL C0002; CC (rec); XX SF the DBD exhibits 94% homology with that of GR [2]; SF binds glucocorticoids and mineralcorticoids with equal affinity [2]; XX FF activator, may mediate mineralocorticoid as well as glucocorticoid-induced transcription [2]; XX IN T05076 GR; human, Homo sapiens. IN T04922 Prox-1; human, Homo sapiens. IN T01345 RXR-alpha; human, Homo sapiens. IN T04632 SRC-1; human, Homo sapiens. IN T19335 TIF1a-short; human, Homo sapiens. XX BS R27057. BS R30951. BS R63672. BS R37862. XX DR TRANSPATH: MO000021449. DR PATHODB: MT010627. DR PATHODB: MT010628. DR PATHODB: MT010629. DR PATHODB: MT010631. DR UniProtKB: P08235; MCR_HUMAN. XX RN [1]; RE0001752. RX PUBMED: 2172797. RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [2]; RE0002637. RX PUBMED: 3037703. RA Arriza J. L., Weinberger C., Cerelli G., Glaser T. M., Handelin B. L., Housman D. E., Evans R. M. RT Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor RL Science 237:268-275 (1987). RN [3]; RE0003721. RX PUBMED: 1655735. RA Alnemri E. S., Maksymowych A. B., Robertson N.M., Litwack G. RT Overexpression and characterization of the human mineralocorticoid receptor RL J. Biol. Chem. 266:18072-18081 (1991). RN [4]; RE0003722. RX PUBMED: 1660146. RA Binart N., Lombes M., Rafestin-Oblin M.-E., Baulieu E.-E. RT Characterization of human mineralocoticosteroid receptor expressed in the baculovirus system RL Proc. Natl. Acad. Sci. USA 88:10681-10685 (1991). RN [5]; RE0013625. RX PUBMED: 10219237. RA Nuclear Receptors Nomenclature Committee. RT A unified nomenclature system for the nuclear receptor superfamily RL Cell 97:161-163 (1999). RN [6]; RE0016449. RX PUBMED: 10428842. RA Hong H., Yang L., Stallcup M. R. RT Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3 RL J. Biol. Chem. 274:22618-22626 (1999). RN [7]; RE0017308. RX PUBMED: 9115274. RA Thenot S., Henriquet C., Rochefort H., Cavailles V. RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 RL J. Biol. Chem. 272:12062-12068 (1997). RN [8]; RE0031301. RX PUBMED: 12194973. RA Planey S. L., Derfoul A., Steplewski A., Robertson N. M., Litwack G. RT Inhibition of glucocorticoid-induced apoptosis in 697 pre-B lymphocytes by the mineralocorticoid receptor N-terminal domain. RL J. Biol. Chem. 277:42188-96 (2002). RN [9]; RE0054989. RX PUBMED: 15604093. RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M. RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. RL Mol. Cell. Proteomics 4:205-213 (2005). XX //