AC T09632
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ID T09632
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DT 10.10.2006 (created); sri.
DT 27.09.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA FXR
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SY bile acid receptor; farnesoid X activated receptor; NR1H4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002745 NR1H4; HGNC: NR1H4.
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CL C0002; CC (rec); 2.1.2.7.3.
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IN T33762 DRIP205; human, Homo sapiens.
IN T05296 PGC-1; mouse, Mus musculus.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T04807 RXR-gamma; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T21552 SRC-1; Mammalia.
IN T15588 T3R-beta1; Mammalia.
IN T31896 VDR; Mammalia.
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MX M07256 V$FXRRXR_Q5.
MX M08953 V$FXR_01.
MX M01268 V$FXR_Q2.
MX M00631 V$FXR_Q3.
MX M03790 V$FXR_Q5.
MX M03795 V$LXR_Q6.
MX M00964 V$PXR_Q2.
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BS R13129.
BS R63219.
BS R63026.
BS R63027.
BS R31809.
BS R31219.
BS R62676.
BS R69805.
BS R69804.
BS R69396.
BS R62692.
BS R27682.
BS R30688.
BS R67343.
BS R41677.
BS R27267.
BS R69844.
BS R72371.
BS R68079.
BS R69807.
BS R69806.
BS R27266.
XX
DR TRANSPATH: MO000088742.
DR UniProtKB: Q96RI1;
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RN [1]; RE0016194.
RX PUBMED: 10334993.
RA Parks D. J., Blanchard S. G., Bledsoe R. K., Chandra G., Consler T. G., Kliewer S. A., Stimmel J. B., Willson T. M., Zavacki A. M., Moore D. D., Lehmann J. M.
RT Bile acids: natural ligands for an orphan nuclear receptor
RL Science 284:1365-1368 (1999).
RN [2]; RE0023349.
RX PUBMED: 10334992.
RA Makishima M., Okamoto A. Y., Repa J. J., Tu H., Learned R. M., Luk A., Hull M. V., Lustig K. D., Mangelsdorf D. J., Shan B.
RT Identification of a nuclear receptor for bile acids.
RL Science 284:1362-1365 (1999).
RN [3]; RE0023352.
RX PUBMED: 12529392.
RA Otte K., Kranz H., Kober I., Thompson P., Hoefer M., Haubold B., Remmel B., Voss H., Kaiser C., Albers M., Cheruvallath Z., Jackson D., Casari G., Koegl M., Paabo S., Mous J., Kremoser C., Deuschle U.
RT Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.
RL Mol. Cell. Biol. 23:864-872 (2003).
RN [4]; RE0032687.
RX PUBMED: 11136553.
RA Bramlett K. S., Yao S., Burris T. P.
RT Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids.
RL Mol. Genet. Metab. 71:609-15 (2000).
RN [5]; RE0032717.
RX PUBMED: 14684751.
RA Lew J. L., Zhao A., Yu J., Huang L., de Pedro N., Pelaez F., Wright S. D., Cui J.
RT The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion.
RL J. Biol. Chem. 279:8856-61 (2004).
RN [6]; RE0048421.
RX PUBMED: 16219912.
RA Johnson D. R., Li C. W., Chen L. Y., Ghosh J. C., Chen J. D.
RT Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).
RL Mol. Pharmacol. 69:99-108 (2006).
RN [7]; RE0050893.
RX PUBMED: 15145977.
RA Nishimaki-Mogami T., Une M., Fujino T., Sato Y., Tamehiro N., Kawahara Y., Shudo K., Inoue K.
RT Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor.
RL J. Lipid Res. 45:1538-1545 (2004).
RN [8]; RE0050991.
RX PUBMED: 16675527.
RA Wang S., Lai K., Moy F. J., Bhat A., Hartman H. B., Evans M. J.
RT The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone.
RL Endocrinology 147:4025-4033 (2006).
RN [9]; RE0051015.
RX PUBMED: 12004058.
RA Cui J., Heard T. S., Yu J., Lo J. L., Huang L., Li Y., Schaeffer J. M., Wright S. D.
RT The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.
RL J. Biol. Chem. 277:25963-25969 (2002).
RN [10]; RE0051051.
RX PUBMED: 15187081.
RA Pineda Torra I., Freedman L. P., Garabedian M. J.
RT Identification of DRIP205 as a coactivator for the Farnesoid X receptor.
RL J. Biol. Chem. 279:36184-36191 (2004).
RN [11]; RE0051070.
RX PUBMED: 16371446.
RA Deng R., Yang D., Yang J., Yan B.
RT Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor.
RL J. Pharmacol. Exp. Ther. 317:317-325 (2006).
RN [12]; RE0051114.
RX PUBMED: 12016314.
RA Makishima M., Lu T. T., Xie W., Whitfield G. K., Domoto H., Evans R. M., Haussler M. R., Mangelsdorf D. J.
RT Vitamin D receptor as an intestinal bile acid sensor.
RL Science 296:1313-1316 (2002).
RN [13]; RE0051138.
RX PUBMED: 15911693.
RA Rizzo G., Renga B., Antonelli E., Passeri D., Pellicciari R., Fiorucci S.
RT The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes.
RL Mol. Pharmacol. 68:551-558 (2005).
RN [14]; RE0051171.
RX PUBMED: 16230354.
RA Nakahara M., Furuya N., Takagaki K., Sugaya T., Hirota K., Fukamizu A., Kanda T., Fujii H., Sato R.
RT Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.
RL J. Biol. Chem. 280:42283-42289 (2005).
RN [15]; RE0051190.
RX PUBMED: 16522742.
RA Honjo Y., Sasaki S., Kobayashi Y., Misawa H., Nakamura H.
RT 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor.
RL J. Endocrinol. 188:635-643 (2006).
RN [16]; RE0051257.
RX PUBMED: 15307955.
RA Zhao A., Yu J., Lew J. L., Huang L., Wright S. D., Cui J.
RT Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets.
RL DNA Cell Biol. 23:519-526 (2004).
RN [17]; RE0051267.
RX PUBMED: 16300737.
RA Nishimaki-Mogami T., Kawahara Y., Tamehiro N., Yoshida T., Inoue K., Ohno Y., Nagao T., Une M.
RT 5Alpha-bile alcohols function as farnesoid X receptor antagonists.
RL Biochem. Biophys. Res. Commun. 339:386-391 (2006).
RN [18]; RE0051270.
RX PUBMED: 15202934.
RA Kanaya E., Shiraki T., Jingami H.
RT The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.
RL Biochem. J. 382:913-921 (2004).
RN [19]; RE0051278.
RX PUBMED: 12525500.
RA Cui J., Huang L., Zhao A., Lew J. L., Yu J., Sahoo S., Meinke P. T., Royo I., Pelaez F., Wright S. D.
RT Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.
RL J. Biol. Chem. 278:10214-10220 (2003).
RN [20]; RE0051282.
RX PUBMED: 15489543.
RA Adachi R., Honma Y., Masuno H., Kawana K., Shimomura I., Yamada S., Makishima M.
RT Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative.
RL J. Lipid Res. 46:46-57 (2005).
RN [21]; RE0051308.
RX PUBMED: 13130122.
RA Fujino T., Une M., Imanaka T., Inoue K., Nishimaki-Mogami T.
RT Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation.
RL J. Lipid Res. 45:132-138 (2004).
RN [22]; RE0051387.
RX PUBMED: 12052824.
RA Yu J., Lo J. L., Huang L., Zhao A., Metzger E., Adams A., Meinke P. T., Wright S. D., Cui J.
RT Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity.
RL J. Biol. Chem. 277:31441-31447 (2002).
RN [23]; RE0051657.
RX PUBMED: 17456796.
RA Ricketts M. L., Boekschoten M. V., Kreeft A. J., Hooiveld G. J., Moen C. J., Muller M., Frants R. R., Kasanmoentalib S., Post S. M., Princen H. M., Porter J. G., Katan M. B., Hofker M. H., Moore D. D.
RT The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.
RL Mol. Endocrinol. 21:1603-1616 (2007).
RN [24]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [25]; RE0071089.
RX PUBMED: 19228886.
RA Martinez-Fernandez P., Hierro L., Jara P., Alvarez L.
RT Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.
RL Am. J. Physiol. Gastrointest. Liver Physiol. 296:G1119-29 (2009).
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