AC T05296
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ID T05296
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DT 22.10.2002 (created); oke.
DT 23.07.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA PGC-1
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SY A830037N07Rik; ENSMUSG00000079510; Gm11133; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator activated receptor gamma coactivator 1 alpha; peroxisome-proliferator-activated receptor gamma, co-activator 1; PGC-1; PGC-1 alpha; Pgc-1alpha; PGC-1v; PGC1; Pgco1; PPAR Gamma Coactivator-1; PPAR gamma coactivator-1 alpha; PPAR-gamma co-activator 1; PPARGC-1 alpha; PPARGC1; PPARGC1A.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004833 Ppargc1a.
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SF the amino-terminal 190 amino acids of PGC-1 are sufficient to mediate a strong interaction with HNF-4alpha transactivation domain [1];
SF the same region is shown to mediate ligand-dependent interactions with AF-2 domains of ERalpha, PPARalpha, GR;
SF PGC-1 interacts with PPARgamma in a ligand-independent fashion;
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EX brain,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX brown fat,,,adult.
EX brown fat,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX heart,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX kidney (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2].
EX liver,,,adult; none; Northern blot; RNA (undefined); [2].
EX lung,,,adult; none; Northern blot; RNA (undefined); [2].
EX muscles,,,adult; none; Northern blot; RNA (undefined); [2].
EX spleen,,,adult; none; Northern blot; RNA (undefined); [2].
EX testis (right and left),,,adult; none; Northern blot; RNA (undefined); [2].
EX white fat,,,adult; none; Northern blot; RNA (undefined); [2].
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FF PGC-1 activates uncoupling-linked and phosphorylation-linked respiration [7];
FF co-activator of PPARgamma, PPARalpha, ERalpha;
FF co-activator of HNF-4alpha and GR [1];
FF may regulate aspects of hepatic glucose metabolism [1];
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IN T09632 FXR; human, Homo sapiens.
IN T03828 HNF-4alpha; human, Homo sapiens.
IN T05287 HNF-4alpha; mouse, Mus musculus.
IN T00673 NRF-1; human, Homo sapiens.
IN T03731 PPARgamma2; human, Homo sapiens.
IN T05347 PPARgamma; mouse, Mus musculus.
IN T15631 SREBP-2; mouse, Mus musculus.
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DR TRANSPATH: MO000033778.
DR UniProtKB: O70343;
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RN [1]; RE0018079.
RX PUBMED: 11557972.
RA Yoon J. C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C. R., Granner D. K., Newgard C. B., Spiegelman B. M.
RT Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
RL Nature 413:131-138 (2001).
RN [2]; RE0018288.
RX PUBMED: 9529258.
RA Puigserver P., Wu Z., Park C. W., Graves R., Wright M., Spiegelman B. M.
RT A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
RL Cell 92:829-839 (1998).
RN [3]; RE0051054.
RX PUBMED: 17636037.
RA Ponugoti B., Fang S., Kemper J. K.
RT Functional interaction of HNF-4 and PGC-1{alpha} in CYP7A1 regulation is inhibited by a key lipogenic activator, SREBP-1c.
RL Mol. Endocrinol. 11:2698-712 (2007).
RN [4]; RE0051270.
RX PUBMED: 15202934.
RA Kanaya E., Shiraki T., Jingami H.
RT The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.
RL Biochem. J. 382:913-921 (2004).
RN [5]; RE0065191.
RX PUBMED: 17609368.
RA Jager S., Handschin C., St-Pierre J., Spiegelman B. M.
RT AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
RL Proc. Natl. Acad. Sci. USA 104:12017-12022 (2007).
RN [6]; RE0067583.
RX PUBMED: 20661474.
RA Kong X., Wang R., Xue Y., Liu X., Zhang H., Chen Y., Fang F., Chang Y.
RT Sirtuin 3, a New Target of PGC-1alpha, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis.
RL PLoS ONE 5:e11707 (2010).
RN [7]; RE0022195.
RX PUBMED: 10412986.
RA Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R. C., Spiegelman B. M.
RT Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
RL Cell 98:115-124 (1999).
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