AC T05287
AS T01181.
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ID T05287
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DT 21.10.2002 (created); oke.
DT 22.06.2016 (updated); mom.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha
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SY AF-1; hepatocyte nuclear factor 4 alpha; HNF4; HNF4A; NR2A1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001173 Hnf4a.
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CL C0002; CC (rec); 2.1.3.2.1.
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SF forms homodimers;
SF at least 3 splice variants are known: HNF-4alpha1 T02424, HNF-4alpha2 T02423, HNF-4alpha7 T02427;
SF AF-1 identified as HNF-4 [3];
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FF HNF-4alpha is required for proper functioning of K(ATP) channel activity in the pancreatic beta-cells [11];
FF HNF-4alpha is involved in glucose-stimulated insulin secretion [11];
FF activator of liver-specific genes [4];
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IN T14136 PC4; mouse, Mus musculus.
IN T05296 PGC-1; mouse, Mus musculus.
IN T28267 PGC-1; Mammalia.
IN T01556 SREBP-1a; human, Homo sapiens.
IN T08890 SREBP-1C; mouse, Mus musculus.
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M02868 V$HNF4A_02.
MX M02764 V$HNF4A_04.
MX M07321 V$HNF4A_Q3.
MX M02016 V$HNF4A_Q6_01.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R25058.
BS R15841.
BS R15842.
BS R16063.
BS R60270.
BS R01612.
BS R02657.
BS R15917.
BS R23481.
BS R62684.
BS R14648.
BS R15940.
BS R15941.
BS R31248.
BS R25941.
BS R35733.
BS R25937.
BS R38854.
BS R68510.
BS R63960.
BS R63962.
BS R42179.
BS R26650.
BS R63945.
BS R63976.
BS R63968.
BS R63970.
BS R62838.
BS R25967.
BS R63983.
BS R35738.
BS R20585.
BS R66637.
BS R56408.
BS R13055.
BS R33456.
BS R73706.
BS R28230.
BS R62836.
BS R62839.
BS R63978.
BS R63966.
BS R62832.
BS R31513.
BS R62990.
BS R62991.
BS R40125.
BS R40129.
BS R63947.
BS R63951.
BS R41903.
BS R26531.
BS R20866.
BS R26316.
BS R26652.
BS R56419.
BS R57890.
BS R57902.
BS R63986.
BS R21001.
BS R21003.
BS R31014.
BS R26649.
BS R42303.
BS R62804.
BS R63956.
BS R62833.
BS R19289.
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DR TRANSPATH: MO000033339.
DR TRANSCOMPEL: C00292.
DR TRANSCOMPEL: C00457.
DR EMBL: AF015275; AF015275.
DR EMBL: D29015; MMHNF.
DR UniProtKB: P49698; HNF4_MOUSE.
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RN [1]; RE0000898.
RX PUBMED: 2777781.
RA Leff T., Reue K., Melian A., Culver H., Breslow J. L.
RT A Regulatory Element in the ApoCIII Promoter That Directs Hepatic Specific Transcription Binds to Proteins in Expressing and Nonexpressing Cell Types
RL J. Biol. Chem. 264:16132-16137 (1989).
RN [2]; RE0002747.
RX PUBMED: 2161847.
RA Metzger S., Leff T., Breslow J. L.
RT Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells
RL J. Biol. Chem. 265:9978-9983 (1990).
RN [3]; RE0007472.
RX PUBMED: 8344962.
RA Metzger S., Halaas J. L., Breslow J. L., Sladek F. M.
RT Orphan Receptor HNF-4 and bZip protein C/EBPalpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription
RL J. Biol. Chem. 268:16831- 16838 (1993).
RN [4]; RE0018066.
RX PUBMED: 11573935.
RA Nakayama K., Sudo Y., Sasaki Y., Iwata H., Takahashi M., Kamataki T.
RT Studies on transcriptional regulation of Cyp3a16 gene in mouse livers by application of direct DNA injection method.
RL Biochem. Biophys. Res. Commun. 287:820-824 (2001).
RN [5]; RE0048264.
RX PUBMED: 14530276.
RA Petrescu A. D., Payne H. R., Boedecker A., Chao H., Hertz R., Bar-Tana J., Schroeder F., Kier A. B.
RT Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha.
RL J. Biol. Chem. 278:51813-51824 (2003).
RN [6]; RE0051054.
RX PUBMED: 17636037.
RA Ponugoti B., Fang S., Kemper J. K.
RT Functional interaction of HNF-4 and PGC-1{alpha} in CYP7A1 regulation is inhibited by a key lipogenic activator, SREBP-1c.
RL Mol. Endocrinol. 11:2698-712 (2007).
RN [7]; RE0052181.
RX PUBMED: 16003322.
RA Marroquin C. E., Wai P. Y., Kuo P. C., Guo H.
RT Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4.
RL Surgery 138:93-99 (2005).
RN [8]; RE0052616.
RX PUBMED: 12466152.
RA Guo H., Wei J., Inoue Y., Gonzalez F. J., Kuo P. C.
RT Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.
RL Am. J. Physiol. Cell Physiol. 284:C1090-9 (2003).
RN [9]; RE0054769.
RX PUBMED: 16807375.
RA Shin M., Kim I., Inoue Y., Kimura S., Gonzalez F. J.
RT Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
RL Mol. Pharmacol. 70:1281-1290 (2006).
RN [10]; RE0055387.
RX PUBMED: 17403900.
RA Sumi K., Tanaka T., Uchida A., Magoori K., Urashima Y., Ohashi R., Ohguchi H., Okamura M., Kudo H., Daigo K., Maejima T., Kojima N., Sakakibara I., Jiang S., Hasegawa G., Kim I., Osborne T. F., Naito M., Gonzalez F. J., Hamakubo T., Kodama T., Sakai J.
RT Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.
RL Mol. Cell. Biol. 27:4248-4260 (2007).
RN [11]; RE0065341.
RX PUBMED: 16377800.
RA Miura A., Yamagata K., Kakei M., Hatakeyama H., Takahashi N., Fukui K., Nammo T., Yoneda K., Inoue Y., Sladek F. M., Magnuson M. A., Kasai H., Miyagawa J., Gonzalez F. J., Shimomura I.
RT Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
RL J. Biol. Chem. 281:5246-5257 (2006).
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