AC T08890
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ID T08890
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DT 08.05.2006 (created); sla.
DT 25.04.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA SREBP-1C
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SY 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630008H06 product:sterol regulatory element binding factor 1, full insert sequence; 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430002C06 product:sterol regulatory element binding factor 1, full insert sequence; ADD-1; sterol regulatory element binding factor 1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002466 Srebf1.
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CL C0012; bHLH-ZIP.
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SZ 1110 AA; 118.0 kDa (cDNA) (calc.).
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SQ MDCTFEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGANSPESFSSASLASSLEAF
SQ LGGPKVTPAPLSPPPSAPAALKMYPSVSPFSPGPGIKEEPVPLTILQPAAPQPSPGTLLP
SQ PSFPAPPVQLSPAPVLGYSSLPSGFSGTLPGNTQQPPSSLPLAPAPGVLPTPALHTQVQS
SQ LASQQPLPASAAPRTNTVTSQVQQVPVVLQPHFIKADSLLLTAVKTDAGATVKTAGISTL
SQ APGTAVQAGPLQTLVSGGTILATVPLVVDTDKLPIHRLAAGSKALGSAQSRGEKRTAHNA
SQ IEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSA
SQ HKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSFGSRASSSG
SQ GSDSEPDSPAFEDSQVKAQRLPSHSRGMLDRSRLALCVLAFLCLTCNPLASLFGWGILTP
SQ SDATGTHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPH
SQ SGPAVHFWRHRKQADLDLARGDFPQAAQQLWLALQALGRPLPTSNLDLACSLLWNLIRHL
SQ LQRLWVGRWLAGQAGGLLRDRGLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLAASNL
SQ ALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGS
SQ VPLAMQWLCHPVGHRFFVDGDWAVHGAPPESLYSVAGNPVDPLAQVTRLFREHLLERALN
SQ CIAQPSPGAADGDREFSDALGYLQLLNSCSDAAGAPACSFSVSSSMAATTGPDPVAKWWA
SQ SLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQDTERPLPRAALYSFKAARALLDHRKVES
SQ SPASLAICEKASGYLRDSLASTPTGSSIDKAMQLLLCDLLLVARTSLWQRQQSPASVQVA
SQ HGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLL
SQ DRSLRRRAGSSGKGGTTAELEPRPTWREHTEALLLASCYLPPAFLSAPGQRMSMLAEAAR
SQ TVEKLGDHRLLLDCQQMLLRLGGGTTVTSS
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SC Swiss-Prot#Q9WTN3-3
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FF helix-loop-helix domain of SREBP-1C (residues 309-344) interact with the A-Box of HMGB1 [2];
FF HMGB1 enhances SREBPs binding to SRE sequence [2];
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IN T05287 HNF-4alpha; mouse, Mus musculus.
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MX M00220 V$SREBP1_01.
MX M00221 V$SREBP1_02.
MX M01173 V$SREBP1_Q5.
MX M00749 V$SREBP1_Q6.
MX M04632 V$SREBP1_Q6_01.
MX M00776 V$SREBP_Q3.
MX M01168 V$SREBP_Q6.
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BS R61530.
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DR TRANSPATH: MO000081059.
DR EMBL: BC056922; BC056922.
DR UniProtKB: Q9WTN3-3;
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RN [1]; RE0051054.
RX PUBMED: 17636037.
RA Ponugoti B., Fang S., Kemper J. K.
RT Functional interaction of HNF-4 and PGC-1{alpha} in CYP7A1 regulation is inhibited by a key lipogenic activator, SREBP-1c.
RL Mol. Endocrinol. 11:2698-712 (2007).
RN [2]; RE0047706.
RX PUBMED: 16040616.
RA Najima Y., Yahagi N., Takeuchi Y., Matsuzaka T., Sekiya M., Nakagawa Y., Amemiya-Kudo M., Okazaki H., Okazaki S., Tamura Y., Iizuka Y., Ohashi K., Harada K., Gotoda T., Nagai R., Kadowaki T., Ishibashi S., Yamada N., Osuga J., Shimano H.
RT High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
RL J. Biol. Chem. 280:27523-27532 (2005).
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