AC T00673
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ID T00673
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DT 15.10.1992 (created); ewi.
DT 21.08.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA NRF-1
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SY alpha-PAL; alpha-palindrome-binding protein; nuclear respiratory factor 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004142 NRF1; HGNC: NRF1.
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HO P3A2 (sea urchin), EWG (D. melanogaster).
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CL C0064; unchar-DBD; 0.0.6.0.1.
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SF putatively an unusual member of the bZIP family of transcription factors;
SF protein sequence and DNA recognition site strongly homologous to those of the factors P3A2 and ewg, and therefore also assumed to constitute an own class of transcription factors with them [5] [4];
SF the basic region may be the DNA-binding domain [5] [6];
SF pI (calc.)=2.4 [5];
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FF may be play a key role in cellular adaption to energy demands by translating physiological signals into an increased capacity for generating energy [7];
FF NRF-1 is necessary for the induction of ALA synthase expression [7];
FF suggested to modulate transcription of metabolic genes important for cell growth [5];
FF transcriptional regulator of genes encoding respiratory chain subunits [3] [1];
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IN T05296 PGC-1; mouse, Mus musculus.
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MX M07296 V$MAF_Q4.
MX M04694 V$NRF1_03.
MX M04862 V$NRF1_04.
MX M07052 V$NRF1_Q5.
MX M00652 V$NRF1_Q6.
MX M02102 V$NRF1_Q6_01.
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BS R58669.
BS R58670.
BS R25881.
BS R20787.
BS R58097.
BS R58094.
BS R22151.
BS R22153.
BS R58106.
BS R58671.
BS R58667.
BS R58093.
BS R21560.
BS R58030.
BS R73166.
BS R58090.
BS R58023.
BS R58036.
BS R58026.
BS R22773.
BS R58101.
BS R58014.
BS R22771.
BS R58095.
BS R63493.
BS R56417.
BS R58098.
BS R02670.
BS R58032.
BS R58016.
BS R58033.
BS R58099.
BS R25902.
BS R58028.
BS R32474.
BS R32475.
BS R32476.
BS R58017.
BS R58018.
BS R58020.
BS R58043.
BS R57836.
BS R58096.
BS R58102.
BS R25863.
BS R31995.
BS R58046.
BS R58045.
BS R31199.
BS R21744.
BS R40821.
BS R40823.
BS R29077.
BS R29078.
BS R29079.
BS R29081.
BS R29107.
BS R29082.
BS R29084.
BS R29089.
BS R29091.
BS R29108.
BS R21545.
BS R33427.
BS R32558.
BS R32559.
BS R38173.
BS R38174.
BS R02671.
BS R02223.
BS R02669.
BS R02659.
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DR TRANSPATH: MO000025097.
DR UniProtKB: Q16656;
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RN [1]; RE0000660.
RX PUBMED: 2166701.
RA Evans M. J., Scarpulla R. C.
RT NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells
RL Genes Dev. 4:1023-1034 (1990).
RN [2]; RE0000881.
RX PUBMED: 2584221.
RA Jacob W. F., Silverman T. A., Cohen R. B., Safer B.
RT Identification and Characterization of a Novel Transcription Factor Participating in the Expression of Eukaryotic Initiation Factor 2alpha
RL J. Biol. Chem. 264:20372-20384 (1989).
RN [3]; RE0000899.
RX PUBMED: 2547796.
RA Evans M. J., Scarpulla R. C.
RT Interaction of Nuclear Factors with Multiple Sites in the Somatic Cytochrome c Promoter
RL J. Biol. Chem. 264:14361-14368 (1989).
RN [4]; RE0008290.
RX PUBMED: 8253388.
RA Virbasius C. A., Virbasius J. V., Scarpulla R. C.
RT NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators
RL Genes Dev. 7:2431-2445 (1993).
RN [5]; RE0013596.
RX PUBMED: 8034649.
RA Efiok B. J. S., Chiorini J. A., Safer B.
RT A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development
RL J. Biol. Chem. 269:18921-18930 (1994).
RN [6]; RE0013597.
RX PUBMED: 2389142.
RA Talanian R. V., McKnight C. J., Kim P. S.
RT Sequence-specific DNA binding by a short peptide dimer
RL Science 249:769-771 (1990).
RN [7]; RE0035561.
RX PUBMED: 10364186.
RA Li B., Holloszy J. O., Semenkovich C. F.
RT Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells.
RL J. Biol. Chem. 274:17534-17540 (1999).
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