TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00673 XX ID T00673 XX DT 15.10.1992 (created); ewi. DT 21.08.2014 (updated); pro. CO Copyright (C), QIAGEN. XX FA NRF-1 XX SY alpha-PAL; alpha-palindrome-binding protein; nuclear respiratory factor 1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004142 NRF1; HGNC: NRF1. XX HO P3A2 (sea urchin), EWG (D. melanogaster). XX CL C0064; unchar-DBD; XX SF putatively an unusual member of the bZIP family of transcription factors; SF protein sequence and DNA recognition site strongly homologous to those of the factors P3A2 and ewg, and therefore also assumed to constitute an own class of transcription factors with them [5] [4]; SF the basic region may be the DNA-binding domain [5] [6]; SF pI (calc.)=2.4 [5]; XX FF may be play a key role in cellular adaption to energy demands by translating physiological signals into an increased capacity for generating energy [7]; FF NRF-1 is necessary for the induction of ALA synthase expression [7]; FF suggested to modulate transcription of metabolic genes important for cell growth [5]; FF transcriptional regulator of genes encoding respiratory chain subunits [3] [1]; XX IN T05296 PGC-1; mouse, Mus musculus. XX MX M07296 V$MAF_Q4. MX M04694 V$NRF1_03. MX M04862 V$NRF1_04. MX M07052 V$NRF1_Q5. MX M00652 V$NRF1_Q6. MX M02102 V$NRF1_Q6_01. XX BS R58669. BS R58670. BS R25881. BS R20787. BS R58097. BS R58094. BS R22151. BS R22153. BS R58106. BS R58671. BS R58667. BS R58093. BS R21560. BS R58030. BS R73166. BS R58090. BS R58023. BS R58036. BS R58026. BS R22773. BS R58101. BS R58014. BS R22771. BS R58095. BS R63493. BS R56417. BS R58098. BS R02670. BS R58032. BS R58016. BS R58033. BS R58099. BS R25902. BS R58028. BS R32474. BS R32475. BS R32476. BS R58017. BS R58018. BS R58020. BS R58043. BS R57836. BS R58096. BS R58102. BS R25863. BS R31995. BS R58046. BS R58045. BS R31199. BS R21744. BS R40821. BS R40823. BS R29077. BS R29078. BS R29079. BS R29081. BS R29107. BS R29082. BS R29084. BS R29089. BS R29091. BS R29108. BS R21545. BS R33427. BS R32558. BS R32559. BS R38173. BS R38174. BS R02671. BS R02223. BS R02669. BS R02659. XX DR TRANSPATH: MO000025097. DR UniProtKB: Q16656; XX RN [1]; RE0000660. RX PUBMED: 2166701. RA Evans M. J., Scarpulla R. C. RT NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells RL Genes Dev. 4:1023-1034 (1990). RN [2]; RE0000881. RX PUBMED: 2584221. RA Jacob W. F., Silverman T. A., Cohen R. B., Safer B. RT Identification and Characterization of a Novel Transcription Factor Participating in the Expression of Eukaryotic Initiation Factor 2alpha RL J. Biol. Chem. 264:20372-20384 (1989). RN [3]; RE0000899. RX PUBMED: 2547796. RA Evans M. J., Scarpulla R. C. RT Interaction of Nuclear Factors with Multiple Sites in the Somatic Cytochrome c Promoter RL J. Biol. Chem. 264:14361-14368 (1989). RN [4]; RE0008290. RX PUBMED: 8253388. RA Virbasius C. A., Virbasius J. V., Scarpulla R. C. RT NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators RL Genes Dev. 7:2431-2445 (1993). RN [5]; RE0013596. RX PUBMED: 8034649. RA Efiok B. J. S., Chiorini J. A., Safer B. RT A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development RL J. Biol. Chem. 269:18921-18930 (1994). RN [6]; RE0013597. RX PUBMED: 2389142. RA Talanian R. V., McKnight C. J., Kim P. S. RT Sequence-specific DNA binding by a short peptide dimer RL Science 249:769-771 (1990). RN [7]; RE0035561. RX PUBMED: 10364186. RA Li B., Holloszy J. O., Semenkovich C. F. RT Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells. RL J. Biol. Chem. 274:17534-17540 (1999). XX //