AC T00859
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ID T00859
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DT 28.01.1993 (created); hse.
DT 20.05.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA TTF-1
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SY Homeobox protein Nkx-2.1; Nkx-2.1; Nkx2.1; T/EBP; thyroid nuclear factor 1; TTF-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004905 Nkx2-1.
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CL C0053; NK-2/Nkx; 3.1.2.14.1.
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SF expression in the neural plate (embryonal) is induced by sonic hedgehog (Shh) [4];
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CP (embryonic) neural plate [5].
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FF synergistic activation with Gata4 T02716 on cardiac-specific promoters [7];
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IN T16150 BRG1; mouse, Mus musculus.
IN T30560 ErbB4; mouse, Mus musculus.
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MX M01312 V$NKX21_01.
MX M00432 V$TITF1_Q3.
MX M02034 V$TTF1_Q5.
MX M03891 V$TTF1_Q5_01.
MX M00794 V$TTF1_Q6.
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BS R16087.
BS R16089.
BS R12979.
BS R12981.
BS R67715.
BS R67717.
BS R61105.
BS R35606.
BS R13201.
BS R56655.
BS R13153.
BS R31311.
BS R13174.
BS R41585.
BS R73189.
BS R29600.
BS R39782.
BS R13198.
BS R01882.
BS R02257.
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DR TRANSPATH: MO000025225.
DR UniProtKB: P50220;
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RN [1]; RE0000467.
RX PUBMED: 1976511.
RA Guazzi S., Price M., de Felice M., Damante G., Mattei M., Di Lauro R.
RT Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity
RL EMBO J. 9:3631-3639 (1990).
RN [2]; RE0000696.
RX PUBMED: 1989905.
RA Avvedimento V. E., Musti A. M., Ueffing M., Obici S., Gallo A., Sanchez M., DeBrasi D., Gottesman M. E.
RT Reversible inhibition of a thyroid-specific trans-acting factor by Ras
RL Genes Dev. 5:22-28 (1991).
RN [3]; RE0001499.
RX PUBMED: 1922026.
RA Mizuno K., Gonzales F. J., Kimura S.
RT Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1
RL Mol. Cell. Biol. 11:4927-4993 (1991).
RN [4]; RE0006697.
RX PUBMED: 9226442.
RA Shimamura K., Rubenstein J. L. R.
RT Inductive interactions direct early regionalization of the mouse forebrain
RL Development 124:2709-2718 (1997).
RN [5]; RE0006700.
RX PUBMED: 7774016.
RA Ericson J., Muhr J., Placzek M., Lints T., Jessell T. M., Edlund T.
RT Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube
RL Cell 81:747-756 (1995).
RN [6]; RE0015674.
RX PUBMED: 9533954.
RA Qiu M., Shimamura K., Sussel L., Chen S., Rubenstein J. L.
RT Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
RL Mech. Dev. 72:77-88 (1998).
RN [7]; RE0025027.
RX PUBMED: 9584181.
RA Sepulveda J. L., Belaguli N., Nigam V., Chen C. Y., Nemer M., Schwartz R. J.
RT GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression.
RL Mol. Cell. Biol. 18:3405-3415 (1998).
RN [8]; RE0049366.
RX PUBMED: 16461352.
RA Maeda Y., Hunter T. C., Loudy D. E., Dave V., Schreiber V., Whitsett J. A.
RT PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B.
RL J. Biol. Chem. 281:9600-9606 (2006).
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