AC T04217
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ID T04217
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DT 23.01.2001 (created); dkl.
DT 14.06.2013 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Smad7
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SY Smad-7.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002306 SMAD7; HGNC: SMAD7.
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CL C0041; SMAD; 7.1.1.3.2.
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IN T04106 HDAC1; human, Homo sapiens.
IN T05490 Hic-5; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T04220 Smad6; human, Homo sapiens.
IN T00764 SRF; human, Homo sapiens.
IN T27178 Tsc-22; human, Homo sapiens.
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MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000020634.
DR UniProtKB: O15105; O14740.
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RN [1]; RE0006197.
RX PUBMED: 9335507.
RA Nakao A., Afrakhte M., Moren A., Nakayama T., Christian J. L., Heuchel R., Itoh S., Kawabata M., Heldin N. E., Heldin C. H., ten Dijke P.
RT Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
RL Nature 389:631-635 (1997).
RN [2]; RE0015540.
RX PUBMED: 9705232.
RA Bhushan A., Chen Y., Vale W.
RT Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos
RL Dev. Biol. 200:260-268 (1998).
RN [3]; RE0039135.
RX PUBMED: 14657019.
RA Koinuma D., Shinozaki M., Komuro A., Goto K., Saitoh M., Hanyu A., Ebina M., Nukiwa T., Miyazawa K., Imamura T., Miyazono K.
RT Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7
RL EMBO J. 22:6458-70 (2003).
RN [4]; RE0042810.
RX PUBMED: 12408818.
RA Gronroos E., Hellman U., Heldin C. H., Ericsson J.
RT Control of Smad7 stability by competition between acetylation and ubiquitination
RL Mol. Cell 10:483-93 (2002).
RN [5]; RE0046995.
RX PUBMED: 15221015.
RA Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K.
RT Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)
RL Oncogene 23:6914-23 (2004).
RN [6]; RE0049221.
RX PUBMED: 12151385.
RA Suzuki C., Murakami G., Fukuchi M., Shimanuki T., Shikauchi Y., Imamura T., Miyazono K.
RT Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.
RL J. Biol. Chem. 277:39919-39925 (2002).
RN [7]; RE0049583.
RX PUBMED: 17327236.
RA Seong H. A., Jung H., Kim K. T., Ha H.
RT 3-phosphoinositide-dependent protein kinase-1 (PDK1) negatively regulates TGF-beta -induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
RL J. Biol. Chem. 282:12272-12289 (2007).
RN [8]; RE0060832.
RX PUBMED: 16690609.
RA Camoretti-Mercado B., Fernandes D. J., Dewundara S., Churchill J., Ma L., Kogut P. C., McConville J. F., Parmacek M. S., Solway J.
RT Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7.
RL J. Biol. Chem. 281:20383-20392 (2006).
RN [9]; RE0070931.
RX PUBMED: 20592275.
RA Giroux M., Delisle J. S., O Brien A., Hebert M. J., Perreault C.
RT T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.
RL J. Immunol. 185:1568-1576 (2010).
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