AC T04220
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ID T04220
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DT 23.01.2001 (created); dkl.
DT 26.05.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Smad6
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SY JV-15-1; Smad-6.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002407 SMAD6; HGNC: SMAD6.
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CL C0041; SMAD; 7.1.1.3.1.
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EX heart,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX kidney (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2].
EX liver,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX lung (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2].
EX pancreas,,,adult; detectable; Northern blot; RNA (undefined); [2].
EX placenta,,,adult; detectable; Northern blot; RNA (undefined); [2].
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IN T05222 CtBP1; human, Homo sapiens.
IN T09364 Dlx-3; human, Homo sapiens.
IN T09390 Dlx-7; human, Homo sapiens.
IN T03885 Smad1; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
IN T04217 Smad7; human, Homo sapiens.
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MX M08897 V$SMAD_Q4.
MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000020399.
DR UniProtKB: O43541; O43541.
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RN [1]; RE0015609.
RX PUBMED: 9436979.
RA Hata A., Lagna G., Massague J., Hemmati-Brivanlou A.
RT Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
RL Genes Dev. 12:186-197 (1998).
RN [2]; RE0015642.
RX PUBMED: 9335505.
RA Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K.
RT Smad6 inhibits signalling by the TGF-beta superfamily
RL Nature 389:622-626 (1997).
RN [3]; RE0048385.
RX PUBMED: 16687405.
RA Berghorn K. A., Clark-Campbell P. A., Han L., McGrattan M., Weiss R. S., Roberson M. S.
RT Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding.
RL J. Biol. Chem. 281:20357-20367 (2006).
RN [4]; RE0049823.
RX PUBMED: 16951688.
RA Choi K. C., Lee Y. S., Lim S., Choi H. K., Lee C. H., Lee E. K., Hong S., Kim I. H., Kim S. J., Park S. H.
RT Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.
RL Nat. Immunol. 7:1057-1065 (2006).
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