AC T03885
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ID T03885
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DT 29.09.2000 (created); dkl.
DT 08.09.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Smad1
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SY Madr1; SMAD-1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002393 SMAD1; HGNC: SMAD1.
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HO Smad1 (Xenopus, T04432, [5]), Mad (Drosophila,T04378 [3]) [3] [5].
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CL C0041; SMAD; 7.1.1.1.1.
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SF identical to Madr1 [3];
SF NLS (Nuclear Localization Signal) determines the ligand-induced nuclear translocation [8];
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EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [9].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [9].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [9].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [9].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [9].
EX brain,,,adult; medium; Northern blot; mRNA (poly-A); [9].
EX colon,,,adult; low; Northern blot; mRNA (poly-A); [9].
EX heart,,,adult; high; Northern blot; mRNA (poly-A); [9].
EX kidney (right and left),,,adult; low; Northern blot; mRNA (poly-A); [9].
EX liver,,,adult; high; Northern blot; mRNA (poly-A); [9].
EX lung (right and left),,,adult; low; Northern blot; mRNA (poly-A); [9].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [9].
EX ovary (right and left),,,adult; high; Northern blot; mRNA (poly-A); [9].
EX pancreas,,,adult; high; Northern blot; mRNA (poly-A); [9].
EX placenta,,,adult; medium; Northern blot; mRNA (poly-A); [9].
EX prostate gland,,,adult; medium; Northern blot; mRNA (poly-A); [9].
EX small intestine,,,adult; medium; Northern blot; mRNA (poly-A); [9].
EX spleen,,,adult; high; Northern blot; mRNA (poly-A); [9].
EX testis (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [9].
EX thymus,,,adult; medium; Northern blot; mRNA (poly-A); [9].
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FF Smad1(N), a construct lacking the C-terminal region, and full length Smad1, both are able to induce ventralization, whereas ventralization activity is inhibited by calmodulin, in Xenopus embryos [7];
FF transcriptional activity is located in C-terminal domain [2];
FF functions downstream of BMP4 [2];
FF relocalizes from the cytoplasm to the nucleus in response to BMP [2] [3];
FF BMP stimulation increases Smad1 phosphorylation [2];
FF BMP2-dependent phosphorylation together with ActR-IIB/BMPRII (receptor-type II) and ALK3 (receptor-type I) [3];
FF phosphorylation by ALK-3 signaling pathways [6];
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IN T05490 Hic-5; human, Homo sapiens.
IN T34370 RN3; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
IN T04220 Smad6; human, Homo sapiens.
IN T22875 YAP; Mammalia.
IN T22876 YAP; human, Homo sapiens.
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MX M01590 V$SMAD1_01.
MX M03845 V$SMAD1_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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BS R31709.
BS R35074.
BS R36128.
BS R70852.
BS R10099.
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DR TRANSPATH: MO000019609.
DR UniProtKB: Q15797; Q15797.
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RN [1]; RE0015116.
RX PUBMED: 8673135.
RA Riggins G.J., Thiagalingam S., Rozenblum E., Weinstein C.L., Kern S.E., Hamilton S.R., Willson J.K., Markowitz S.D., Kinzler K.W., Vogelstein B.
RT Mad-related genes in the human
RL Nat. Genet. 13:347-349 (1996).
RN [2]; RE0015117.
RX PUBMED: 8637600.
RA Liu F., Hata A., Baker J.C., Doody J., Carcamo J., Harland R.M., Massague J.
RT A human Mad protein acting as a BMP-regulated transcriptional activator
RL Nature 381:620-623 (1996).
RN [3]; RE0015118.
RX PUBMED: 8653785.
RA Hoodless P.A., Haerry T., Abdollah S., Stapleton M., O'Connor M.B., Attisano L., Wrana J.L.
RT MADR1, a MAD-related protein that functions in BMP2 signaling pathways
RL Cell 85:489-500 (1996).
RN [4]; RE0015119.
RX PUBMED: 8663601.
RA Lechleider R. J., de Caestecker M. P., Dehejia A., Polymeropoulos M. H., Roberts A. B.
RT Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1
RL J. Biol. Chem. 271:17617-17620 (1996).
RN [5]; RE0015704.
RX PUBMED: 8653784.
RA Graff J. M., Bansal A., Melton D. A.
RT Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily
RL Cell 85:479-487 (1996).
RN [6]; RE0015705.
RX PUBMED: 8752209.
RA Eppert K., Scherer S. W., Ozcelik H., Pirone R., Hoodless P., Kim H., Tsui L. C., Bapat B., Gallinger S., Andrulis I. L., Thomsen G. H., Wrana J. L., Attisano L.
RT MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
RL Cell 86:543-552 (1996).
RN [7]; RE0016084.
RX PUBMED: 10329393.
RA Xu R. H., Lechleider R. J., Shih H. M., Hao C. F., Sredni D., Roberts A. B., Kung H. F.
RT Functional analysis of human Smad1: role of the amino-terminal domain.
RL Biochem. Biophys. Res. Commun. 258:366-373 (1999).
RN [8]; RE0016203.
RX PUBMED: 10884415.
RA Xiao Z., Liu X., Henis Y. I., Lodish H. F.
RT A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation.
RL Proc. Natl. Acad. Sci. USA 97:7853-7858 (2000).
RN [9]; RE0016458.
RX PUBMED: 9006934.
RA Nakao A., Roijer E., Imamura T., Souchelnytskyi S., Stenman G., Heldin C. H., ten Dijke P.
RT Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway
RL J. Biol. Chem. 272:2896-2900 (1997).
RN [10]; RE0020652.
RX PUBMED: 11509558.
RA Xiao Z., Watson N., Rodriguez C., Lodish H. F.
RT Nucleocytoplasmic shuttling of smad1 conferred by its nuclear localization and nuclear export signals
RL J. Biol. Chem. 276:39404-39410 (2001).
RN [11]; RE0032276.
RX PUBMED: 14612411.
RA Kim D. W., Lassar A. B.
RT Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
RL Mol. Cell. Biol. 23:8704-17 (2003).
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