AC T04432
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ID T04432
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DT 18.04.2001 (created); dkl.
DT 16.04.2014 (updated); mka.
CO Copyright (C), QIAGEN.
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FA Smad1
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SY SMAD-1.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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GE G002394 smad1.S.
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CL C0041; SMAD; 7.1.1.1.1.
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SZ 464 AA; 52.3 kDa (calc.), 52.3 (kDa)
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SQ MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
SQ PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEYPFGSKQKEV
SQ CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLEPSEPHMPHNATFPDSFQQPN
SQ SHPFPHSPNSSYPNSPGSGSTYPHSPASSDPGSPFQIPADTPPPAYMPPEDQMTQDNSQP
SQ MDTNLMVPNISQDINRADVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTD
SQ PSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCN
SQ FHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWG
SQ AECHRQNVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
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SC translated from EMBL #L77888
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FT 1 69 
MH1 domain [1].
FT 12 136 
PS51075; MH1.
FT 25 134 
SM00523; dwAneu5.
FT 27 131 
PF03165; MH1 domain.
FT 31 429 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 70 269 
Linker region [1].
FT 264 442 
PF03166; MH2 domain.
FT 268 440 
SM00524; DWB.
FT 270 460 
MH2 domain [1].
FT 270 464 
PS51076; MH2.
FT 461 464 SSXS motif [1].
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CP (embryo): stage 8 (blastula): expression in animal, marginal and vegetal section [2]; stage 10: in dorsal and ventral marginal zones [2]; [2].
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FF high homology to Smad1.1 T03886, which contains 3 more amino acids (LMD) at the C-terminus;
FF amino acids at positions 260, 423 and 427 are different;
FF transduce BMP set of signals for ventral mesoderm induction [2];
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IN T04864 SIP1; mouse, Mus musculus.
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MX M01590 V$SMAD1_01.
MX M03845 V$SMAD1_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000020390.
DR EMBL: L77888; XLXMADA.
DR UniProtKB: Q91913; Q91913.
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RN [1]; RE0015128.
RX PUBMED: 10525190.
RA Muller F., Blader P., Rastegar S., Fischer N., Knochel W., Strahle U.
RT Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo
RL Mech. Dev. 88:73-88 (1999).
RN [2]; RE0015704.
RX PUBMED: 8653784.
RA Graff J. M., Bansal A., Melton D. A.
RT Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily
RL Cell 85:479-487 (1996).
RN [3]; RE0018471.
RX PUBMED: 10458166.
RA Zhu H., Kavsak P., Abdollah S., Wrana J. L., Thomsen G. H.
RT A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
RL Nature 400:687-693 (1999).
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