AC T03886
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ID T03886
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DT 29.09.2000 (created); dkl.
DT 02.06.2004 (updated); cch.
CO Copyright (C), QIAGEN.
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FA Smad1.1
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SY SMAD-1; SMAD-1.1.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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GE G002394 smad1.S.
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CL C0041; SMAD.
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SZ 467 AA; 52.7 kDa (calc.), 52.7 (kDa)
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SQ MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGR
SQ PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEYPFGSKQKEV
SQ CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLEPSEPHMPHNATFPDSFQQPN
SQ SHPFPHSPNSSYPNSPGSGSTYPHSPASSDPGSPFQIPADTPPPAYMPPEDQMTQDNSQP
SQ MDTNLMVPNISQDINRADVRAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTD
SQ PSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCN
SQ FHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWG
SQ AEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVSLMD
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SC translated from EMBL #XLU77639
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FT 2 132 
MH1 domain [1].
FT 12 136 
PS51075; MH1.
FT 25 134 
SM00523; dwAneu5.
FT 27 131 
PF03165; MH1 domain.
FT 31 429 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 133 265 
Linker region [1].
FT 264 442 
PF03166; MH2 domain.
FT 266 460 
MH2 domain [1].
FT 268 440 
SM00524; DWB.
FT 270 464 
PS51076; MH2.
FT 461 464 SSXS motif [1].
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CP (embryo): stage 11 [1].
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FF high homology to Smad1 T04432, which lacks the 3 amino acids (LMD) at the C'-terminus;
FF amino acids at positions 260, 423 and 427 are different;
FF C-terminal transactivation domain (minimal C-terminal domain: sequence from 264 to 466) is both sufficient and essential for causing ventralization of the dorsal mesoderm, participating in BMP signaling [1];
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MX M01590 V$SMAD1_01.
MX M03845 V$SMAD1_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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BS R73967.
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DR TRANSPATH: MO000027806.
DR TRANSCOMPEL: C00194.
DR TRANSCOMPEL: C00200.
DR EMBL: U77639;
DR UniProtKB: P79947;
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RN [1]; RE0015120.
RX PUBMED: 9076683.
RA Meersseman G., Verschueren K., Nelles L., Blumenstock C., Kraft H., Wuytens G., Remacle J., Kozak C.A., Tylzanowski P., Niehrs C., Huylebroeck D.
RT The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
RL Mech. Dev. 61:127-140 (1997).
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